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Biomedical subjects

K G Götestam

Publications and source records attributed to K G Götestam.

15 recordsLinked to original sources
PubMed1978

Subjective effects and vigilance after diazepam and oxazepam in normal subjects.

Twenty-two normal subjects were given single oral doses of diazepam 5 mg, oxazepam 15 mg and placebo in a double-blind cross-over trial. Subjective effects according to a rating scale and performance on a vigilance task were assessed. The results showed a difference between each of the two drugs and placebo, but none between the drugs, with regard to the vigilance test. The results from the rating of subjective effects showed an increase in "tiredness" for both drugs, and a decreased "well-being" for oxazepam.

Attention↗
PubMed1977

Open-field behavior after intravenous amphetamine analogues in rats.

A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 and 60 min, with the three higher doses of amphetamine, stereotyped behaviors interfered with and decreased both ambulation and groomin. Fenfluramine decreased ambulation, rearing, and grooming, and was the only drug to induce backing. The technique seems to be a simple and rapid method to establish dependence liability in amphetamine analogues. Interrater and test-retest reliability was established through ITV recordings.

Animals↗
PubMed1977

A double-blind comparison of two bulk laxatives on geriatric patients.

Bulk laxatives have been said to have a good effect in normalizing both hard and loose stools in geriatric patients as concluded from some open studies. In a double-blind study Vi-Siblin, Lunelax and placebo were compared in the six weeks treatment of 29 patients (8 patients on Vi-Siblin, 8 patients on Lunelax, 13 patients on placebo). Two weeks prior to the study and the two last weeks of the study defecation frequency, consistency of stools and the use of additional laxatives were registered by the personnel. Results showed no significant differences between groups or between substances. From this controlled double-blind study it is not possible to draw any definite conclusions regarding the efficacy of bulk laxatives on geriatric patients.

Aged↗
PubMed1976

Acute tolerance to amphetamine in rats.

Two groups of rats were given amphetamine intravenously at 5-min intervals (5 or 10 mg/kg/h) for 8 h. Two control groups received saline infusions. On the second day a test dose of 10 mg/kg amphetamine was given to all groups. Body temperature, food intake, and motor behavior were registered every 30 or 60 min. The results showed the development of acute tolerance to the hyperthermic effect within 3-5 h. Tolerance was still visible on the 2nd day. There was also tolerance to the anorectic effect, which was evident on the 2nd day. One element of stereotyped behavior (swaying) also decreased during the amphetamine infusions.

Animals↗