PubMed Health⌕ Search

Biomedical subjects

K G Koehler

Publications and source records attributed to K G Koehler.

4 recordsLinked to original sources

The dexamethasone suppression test and thyroid stimulating hormone response to TRH in RDC schizoaffective patients.

The dexamethasone suppression test (DST) brought to light significantly more non-suppression of cortisol secretion in RDC schizoaffectives of the depressed (89%) and of the manic type (67%) than in RDC schizophrenia (25%). However, only in the RDC endogenous depressives, whose pathological DST rate was 57%, was the thyroid stimulating hormone (TSH) response to thyrotrophin releasing hormone (TRH) found to be significantly "blunted". It is suggested that the DST results can be interpreted as partially validating DSM-III's wide major affective disorder since this concept also encompasses all cases with mood-incongruent psychotic features. Furthermore, it is hypothesized that the coupling of DST non-suppression and TSH "blunting" may be important for defining a valid depressive subgroup within these extended clinical boundaries for affective illness.

Adult↗

The Schreber case and affective illness: a research diagnostic re-assessment.

A significant part of Schreber's illness up to the time of his dramatic "schizophrenic switch in February 1894 has been systematically re-evaluated in terms of the Research Diagnostic Criteria (RDC) and of certain additional phenomenological characteristics. On this basis it seems that Schreber suffered from a severe major psychotic depressive disorder with tendencies towards bipolarity for the period in question. A more global, non-systematic RDC-oriented interpretation is then offered for the remaining course of the illness until Schreber's death in 1911.

Depressive Disorder↗

Consistency of Kurt Schneider-oriented diagnosis over 40 years.

Diagnostic rates of routine hospital first and total admissions in various categories of functional mental illness in three strongly Schneider-oriented German psychiatric clinics over 40 years were examined. No matter how centers and categories were compared, statistically significant inconsistency was almost always found. Only first admissions for schizophrenia and mania in Munich and Heidelberg, as well as total schizophrenic admissions in Munich and Homburg/Saar, showed no significant diagnostic differences. However, from a practical point of view, actual percentage differences found in schizophrenia and mania were really not that great; indeed, rather similar diagnostic rates were apparent. This was in contrast to actual large percentage discrepancies shown between Munich on the one hand and Heidelberg and Homburg/Saar on the other with respect to manic-depressive illness and psychotic depression.

Adjustment Disorders↗