Resorption of rib graft to inferior border of the mandible.
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Adult↗
Biomedical subjects
K G Mason
Publications and source records attributed to K G Mason.
Drug induced hypofibrinolysis: a cause of venous thrombosis.
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Animals↗
Surgical trauma and pericardial fibrinolytic activity.
Fibrinolytic activator activity was identified in canine pericardium by fibrin slide and fibrin slide and fibrin plate techniques and shown to be sighnificantly decreased following trauma. Cotton sponge abrasion, heating, drying and use of electrocautery and DC electro-shock significantly decreased pericardial fibrolytic activity. Operative decreases in pericardial fibrinolytic activator activity may be significant in the etiology of postoperative pericardial adhesions and constrictive pericardial syndromes.
Animals↗
The source and removal of microaggregates in aged human blood and human blood components.
Microaggregates are formed during the storage of human blood and are composed largely of platelets and leukocytes. These microparticles reside in the buffy coat fraction of blood. The formation of microaggregates can be successfully prevented by removal of the buffy coat or by treatment of blood with drugs which inhibit platelet function prior to storage. Once formed, the volumes of microaggregates in aged blood can be significantly reduced by washing, centrifugation or treatment with urokinase or streptokinase. Glycerol frozen red blood cells and blood components--packed red blood cells and plasma--are free of microaggregates, and they can be infused without fear of embolic consequence.
Aspirin↗
Microaggregate formation during regional hypoperfusion.
Occlusion of the infrarenal aorta in the dog is associated with formation of microaggregates. Etiologic factors involve stasis, acidosis and hypoperfusion. Upon restoration of flow, microaggregates are transported through the inferior vena cava to the pulmonary circulation as microemboli. The volume of microaggregates appearing in the inferior vena cava after restoration of flow in our experiments is small and seems inadequate to cause significant pulmonary mechanical obstruction. The vasoactivity of these microparticles, although to date unknown, may be significant in the etiology of the pulmonary alterations which were described previously.
Animals↗
The filtration limitations of ultrapore filters.
The filtration effectiveness of four commercially available microaggregate filters was determined using 14-day-old stored human blood in a constant infusion system. All filters significantly reduced the volumes of microaggregates contained in 500 ml. of blood. Three of the filters tested either occluded or failed to effectively remove microdebris from larger volumes of blood. These filters should be employed only for single blood transfusions. A fourth filter--of grid design--was effective in removing microdebris from 2,000 ml. of blood, the limits of the study. When employing microaggregate filters in massive transfusion situations for the prevention of pulmonary dysfunction, filtration characteristics and efficiencies of the filters employed must be known so that inadvertent administration of microdebris to the patient might be prevented.
Animals↗
Evaluation of blood filters: dynamics of platelets and platelet aggregates.
Microaggregates of platelets have been found in stored blood and in extracorporeal circulation systems and the potential microembolism of these particles intensely studied. Four currently available filters were studied for their filtration effectiveness of induced platelet microaggregates and for the removal of normal platelets from blood collected in acid citrate dextrose or heparin. Dacron wool filtration significantly (P less than 0.001) reduced aggregates in 13 to 80 mu sizes to a level similar to that in normal blood. In general, as filtration effectiveness increased so did the elimination of normal platelets.
Animals↗
The effect of agitation of stored human blood on microaggregate formation.
Microaggregates (MA) composed of platelets and white blood cells form during the storage of human blood. These particles are believed to be a cause of pulmonary insufficiency in patients receiving massive blood transfusions. The present controlled study determined the effect of constant gentle agitation of CPD-anticoagulated blood, during storage at 4 C, on the formation of MA. Using a Model T Coulter Counter, it was found that agitated blood contained significantly lower volumes of MA at 7 and 14 days than did nonagitated controls. However, significant elevations, above control levels, of plasma free hemoglobin, lactic dehydrogenase, and potassium indicated significant injury to cellular components of agitated blood. This study raises serious doubts concerning the potential clinical usefulness of blood agitation during storage to prevent MA formation.
Blood Platelets↗
Choroid plexus papilloma. Report of a case with cytologic differential diagnosis.
The cytopathologic features of choroid plexus papilloma observed in the ventricular fluid of a 9-month-old boy are reported and compared with other pediatric central nervous system neoplasms. The cytologic features of choroid plexus papilloma are similar to those of normal choroid plexus and may be difficult to distinguish from those of a well-differentiated papillary ependymoma. However, the cell clusters are distinct from those associated with choroid plexus carcinoma and primitive neuroectodermal tumors.
Choroid Plexus Neoplasms↗