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K G Ober

Publications and source records attributed to K G Ober.

At least 19 recordsLinked to original sources
PubMed1989

[4 decades of surgery of cervix cancer].

An impressive breakthrough of Wertheim's original intentions became evident on analysing the observations, experiences and results obtained from the early 'forties right up to the 'eighties of this century in various hospitals such as the Pathological Institute of the famous Berlin "Charité" Hospital and the Department of Gynaecology of the Universities of Marburg, Cologne and Erlangen. If a large number of patients was analysed in this manner, the operability rose from 40 to 80 percent. Operation mortality during the first 30 days dropped from 15 to 0.5 and fistulas receded from 10 to less than 0.5 percent. The increase in the proportion of cured patients (leaving aside the operation mortality) was about 20 percent, basing on the evaluation method already employed by Wertheim himself. The reasons for this development are discussed and an outlook to the future is outlined.

Female↗
PubMed1988

Surgery for cervical cancer.

A total of 326 squamous cervical cancer patients treated by radical hysterectomy and lymphadenectomy in the Women's Hospital of Erlangen University were analysed according to their survival rates and to the histological examination results of their surgical specimens. A good relationship was found to exist between the pathological anatomical stage of the cancer, tumour volume, incidence of lymph node involvement, and survival rate. The result showed that good results from surgical treatment can be achieved even for very large cancers (Stage IIb) with a high frequency of lymph node involvement.

Carcinoma, Squamous Cell↗
PubMed1988

Adjuvant radiotherapy in patients undergoing surgical treatment for carcinoma of the cervix.

An analysis was made of the results from operations carried out on 1092 patients with cervical cancer during a co-operative study involving four universities. Standardized surgical procedures and histological processing of the surgical specimens were employed throughout. The indication for post-operative irradiation therapy was different in the University Departments. In order to carry out a realistic comparison of the results obtained, tumour extension, histologically determined on the surgical specimen, was used as a criterion, clinical staging not being used. In cases presenting a continuous tumour growth corresponding to histological Stage Ib, the five-year survival rates achieved were 90.5% and 95.6%, respectively, for patients who had received surgical treatment only and those who had had postoperative irradiation therapy. In cases of continuous tumour growth amounting to histological Stage II, the corresponding five-year survival rates were 79.5% and 83.1%. The difference between the survival rates of patients who had had or who had not had postoperative irradiation was not statistically significant. The further proof of tumour parameters in the formation of twin pairs revealed that the prognosis of patients presenting unfavourable tumour characteristics could not be influenced by postoperative irradiation therapy.

Carcinoma↗
PubMed1984

[Financing research in gynecologic hospitals].

Personal observations show that financing of research projects in Departments of Obstetrics and Gynecology have weak points. Some can be defined such as beaurocratic inability and tutelage of experts by lay people. The inexperience of donors of money and the fight for patients result in bad advice. The German Research Society administrates in trust the spending for research of the state. The Research Society has to rely on consultants who often lack intuition for important projects. Many times research money is used for studies of problems which largely already have been solved. The administration of the German Research Society is often overloaded. It is then possible to mislead the German Research Society in groteque manners. It is also detrimental that too many politicians and too many ministeries with too little expertise make too many mistakes especially prior to elections. The consultants should evaluate the use of the German language in their evaluations. After 25 years of participation in academic councils and institutions for research, the conclusion is obvious that the relationship between medical faculties and the universities in general need to be loosend up.

Germany, West↗
PubMed1984

[Surgical treatment of cervix cancer. Treatment results and data on the postoperative course over a minimum of 5 years following uniform surgery and standardized histological examination of the histological material of 1092 patients at 4 university gynecology clinics].

Treatment results of 1092 patients with operated cervical carcinoma were evaluated and assessed on the basis of data supplied by four University Clinics of gynaecology. Surgical treatment and histological processing of all surgical specimens were uniform. Indication for postoperative radiation was determined differently at the individual clinics. The treatment results obtained can be compared with one another not on the basis of clinical stage assessment; the only criterion is the histologically proven extension of the tumour, ascertained via an examination of the surgically obtained specimen. With continuous tumour growth in accordance with stage Ib, the 5-year survival rate after surgery alone was 90.5%, after additional radiation 95.6%. In case of continuous tumour growth in accordance with stage II, the 5-year survival rate after operation alone was 79.5%, after operation and radiation 83.1%. The differences in the 5-year survival rates are statistically not significant. Taking into consideration a discontinuous metastatic tumour growth in the region of the parametric tissue, the 5-year survival rate after operation alone was 72.7%, after subsequent radiation 75%, in case of metastases in the region of the lymph nodes 77.8% and 60.5%, respectively. These differences in survival rates were not statistically verifiable. Furthermore, if individual tumour parameters were tested and statistical pairing was performed, it became evident that prognosis of patients with infaust tumour criteria could not be influenced by postoperative radiation.

Combined Modality Therapy↗
PubMed1983

[Tumor registries--possibilities and risks].

Accurately identified and carefully stored diagnoses could eventually supply important pointers to still unknown laws governing the incidence of cancer. Unfortunately, however, diagnoses which are formulated in a simplified manner, are often overrated. If differentiated analyses are concerned with the large spectrum of variety of cancer, they are often disregarded or, rather, ignored. Hence, the risks involved in the storage of conventional and commonplace concepts in computers are indeed very high. Even if a sharply defined concept such as pregnancy diagnosis during the first three months of pregnancy under the viewpoint of terminator is employed, this may involve the programming of errors which are absolutely weird. It follows from this that utmost caution is advised when propagating the concept of a computerized "cancer register" which is now "en vogue", since this may lead to the institutionalisation of glaring errors and misinterpretations. It would be particularly inane to set up registers as appendices to so-called cancer centres, as suggested by the Federal German Ministry of Labour. Only few persons will be able to imagine and assess the possible consequences of such action.

Adult↗
PubMed1980

[Complications in 1,092 radical abdominal hysterectomies with pelvic lymphadenectomies (author's transl)].

1,092 patients were operated for carcinoma of the uterine cervix according to a standardized radical abdominal hysterectomy with obligatory pelvic lymphadenectomy. The operative specimen showed metastases of the lymph nodes in 45,6% of the cases. In 15% of the cases embolization of tumor cells was found. In 8.7% of the specimes micro-metastases were seen and in 21.9% gross metastases were found. Postoperatively 1.5% of the cases developed bleeding. Ileus occured in 0.7% of the cases. A vesicovaginal fistula occurred in 0.3% of the patients. 1.4% of the patients developed a uretero-vaginal fistula. The operative mortality up to the 30th post-operative day was 1%.

Adult↗
PubMed1979

Early detection of ductal breast cancer: the diagnostic procedure for grouped microcalcifications.

Mammography and xeroradiography for grouped microcalcifications are considered the most effective diagnostic methods to detect occult breast carcinoma. Radiography must direct the surgeon to excise the nonpalpable area. The removal of the tissue with grouped microcalcifications must be confirmed by intraoperative radiological control. The histologic preparation must be guided by radiographic controls. Tissue with calcific deposits is examined by step sections. The diagnostic success depends upon the cooperation between the radiologist, the surgeon, and the pathologist. Our results from 1964 to 1977 have shown a frequency of 14.4% of occult carcinoma. Ductal or lobular carcinomata in situ have been diagnosed in 8.9%. In 9.9% of the patients, cystic disease with severe and atypical proliferations has been encountered.

Biopsy↗
PubMed1979

Early detection of ductal breast cancer: the diagnostic procedure for pathological discharge from the nipple.

Pathologic discharge from the nipple may be the only symptom of an early stage of carcinoma. Galactography is then the diagnostic method of choice to locate intraductal, nonpalpable lesions. The technique of galactography, the adequate surgical approach of pathologic galactographs (milk-duct segment resection), and the appropriate histological work-up of the surgical specimen are demonstrated. We report on 1918 galactographies in 1363 women with pathological discharge. In only 427 cases was a milk duct segment resection necessary (31.4%). In 8.5%, we found invasive intraductal cancer and in 2.9% ductal carcinomata in situ. Only 1 patient with breast cancer had axillary metastases. Extensive intraductal solid, papillary or adenomatous proliferations were found in 11.9% of the patients with excision. In 46.7% of the patients, papillomas were excised, a definitive treatment for this process. The supposition for success in the early diagnosis of cancer is close teamwork among the radiology, surgery and pathology services: the diagnostic result depends upon this. We attribute our yield of exact diagnosis to a very sophisticated histological work-up. We believe that this is necessary to avoid diagnostic failures.

Biopsy↗