PubMed Health⌕ Search

Biomedical subjects

K G Romanchuk

Publications and source records attributed to K G Romanchuk.

At least 19 recordsLinked to original sources
PubMed1996

Studies on associations of antinuclear antibodies with antibodies to an uveitogenic peptide of retinal S antigen in children with uveitis.

OBJECTIVE: To determine if, in children with uveitis, antinuclear antibodies (ANA) are associated with antibodies to an uveitogenic peptide of a soluble retinal antigen and to the homologous nuclear antigen, histone 3 (H3). ANA occur in most children with juvenile rheumatoid arthritis (JRA) and associated uveitis. An uveitogenic segment of retinal soluble antigen (S antigen peptide) is homologous with a similarly uveitogenic peptide of H3. We investigated a possible association between ANA positivity, antibodies to H3, and antibodies to the uveitogenic S antigen peptide. METHODS: The sera of 31 children with uveitis (20 of whom had associated JRA) were tested for the presence of ANA by indirect immunofluorescence. Antibodies to H3 and to an uveitogenic peptide of S antigen (an 18 mer segment having the amino acid sequence DTNLASSTIIKEGIDKTV) were measured by enzyme immunoassay. RESULTS: 19 of 20 children (95%) with JRA and associated uveitis and none of 11 with uveitis not associated with JRA had positive tests for ANA (X2 = 14.97; p < 0.00001). 16 of 19 ANA positive sera from subjects with JRA (84%) displayed reactivity with the chromosomal regions of metaphase cells. 9 of 20 patients with JRA with uveitis (45%) and 2 of 11 patients (18%) with uveitis not associated with JRA had antibodies to H3. Two uveitic patients with JRA (10%) and 2 non-JRA patients with uveitis (18%) reacted with S antigen peptide. Antibodies to H3 occurred significantly more frequently in children with uveitis than in all adult control subjects (X2 = 12.98; p = 0.003) and in adults with uveitis (X2 = 5.62; p = 0.022). CONCLUSION: Humoral immune responses to the uveitogenic peptide of S antigen and the homologous H3 antigen appear not to be uniquely important in the immunopathology of uveitis associated with JRA. Antibodies to isolated H3 do not exclusively account for ANA positivity in the uveitic patient with JRA. A unique immunopathogenic mechanism for the development of uveitis associated with JRA is suggested by the observations that (1) children with uveitis associated with JRA are more likely to be ANA positive than children with uveitis not associated with JRA, and (2) children with uveitis associated with JRA are significantly more likely to be ANA positive and to have antibodies to H3 than adults with uveitis.

Adolescent↗
PubMed1992

Corneal melting after pterygium removal followed by topical mitomycin C therapy.

Right corneal melting and scleral necrosis developed in a 77-year-old man 5 months after pterygium excision followed by topical administration of mitomycin C drops (0.4 mg/mL) for 4 weeks. We believe that these were delayed complications of the mitomycin C therapy, and we caution against prolonged use of the drug postoperatively.

Administration, Topical↗
PubMed1990

Antinuclear antibodies in arthritic and nonarthritic children with uveitis.

We determined whether a positive test for antinuclear antibodies correlated with uveitis only in children with juvenile rheumatoid arthritis (JRA) or whether they also represented a serologic marker for isolated idiopathic chronic uveitis in children. We conclude that the immunopathogenesis of uveitis associated with JRA is different from that of idiopathic chronic uveitis.

Antibodies, Antinuclear↗
PubMed1984

Orbital involvement in chronic lymphocytic leukemia.

In a 68-year-old man with chronic lymphocytic leukemia diagnosed on the basis of peripheral lymphocytosis, marked bilateral exophthalmos developed owing to massive orbital involvement by the disease. At the time there was no lymphadenopathy or evidence of organ infiltration. The response to radiotherapy was excellent. Orbital involvement is rare as an early clinical feature of chronic lymphocytic leukemia but should be considered in the differential diagnosis of bilateral exophthalmos in adults.

Aged↗
PubMed1983

Pseudophakic bullous keratopathy.

Pseudophakic bullous keratopathy (PBK) is a relatively new disease that is rapidly becoming the prime indication for penetrating keratoplasty. From 1977 thru 1981 we performed 81 corneal transplants on 66 eyes for this condition. In our experience, the incidence of PBK, with iris-supported lenses, is five times greater than aphakic bullous keratopathy (ABK). A series of 800 intracapsular cataract extractions (ICCE) with implantation of iris-supported lenses (1975-1979) were reviewed. Thirty-four patients (4.3%) developed PBK (average two years after surgery). In a series of 3,000 simple ICCEs (1955-1980), 24 patients (0.8%) developed ABK. Etiologic factors, methods of prevention, and the results of penetrating keratoplasty are considered. PBK following ICCE is a serious disease entity, usually of multifactorial origin. Though 88% of the patients have clear grafts, a high incidence of associated posterior segment disease tends to nullify the visual result. Planned extracapsular cataract extraction and posterior chamber lens insertion (1979-1982) has reduced our incidence of PBK to 0.3% (1/300). These results are promising but premature.

Aged↗
PubMed1981

Ocular findings in arteriohepatic dysplasia (Alagille's syndrome).

The ocular findings in a father and two offspring with arteriohepatic dysplasia are reported in this paper. All three people had bilateral posterior embryotoxon, Axenfeld's anomaly and a pigmentary retinopathy. Other ocular findings were exotropia, an ectopic pupil, band keratopathy, choroidal folds, anomalous optic discs and infantile myopia. Persons with arteriohepatic dysplasia typically present with prolonged neonatal jaundice. Cognizance of the associated eye findings helps distinguish this syndrome from other types of familial intrahepatic cholestasis.

Adult↗
PubMed1981

Keratophakia. Clinical evaluation.

The keratophakia and keratomileusis procedures of Barraquer for the correction of aphakia have not gained acceptance in the United States because of thier inherent complexity and degree of difficulty. To determine the practicality, feasibility, and visual rehabilitation potential of these procedures, 13 secondary keratophakia operations were performed at a 500-bed community hospital between March 1980 and April 1981. The first ten cases are reported to allow 6- to 12-month follow-up. All patients in the series were resistant to contact lenses or were poor candidates for secondary intraocular lens implantation. The anatomic results were excellent. Complications were minimal consisting of surface drying problems in three patients related to the sudden steepening of the cornea or pseudo keratoconus effect. Seven patients achieved 20/30 to 20/40 vision with minimal spectacle correction. The keratophakia procedure of Barraquer shows promise and can be duplicated by experienced corneal surgeons, but is not yet a viable alternative to the use of primary intraocular lenses and continuous wear lenses for the general ophthalmologist.

Adult↗
PubMed1980

The risk of retina damage from high intensity light sources.

The risk of thermal damage to the retina of the eye by exposure to excessive light intensities from continuous and pulsed man-made sources is discussed. The probability of injury increases, the larger the radiant power absorbed by the retina and the smaller the size of the retinal image of the source. A mehtod of estimating the temperature increase of the immediately affected area of the retina is presented. The time constants involved are also briefly considered. Using numerical values from literature for the relevant parameters of the eye, threshold values for a variety of conditions can be established. Below these values little risk of retina damage should exist. The degree of hazard when these values are exceeded depends upon the circumstances. A case study of a welding accident showed good agreement between the conclusions of the theoretical analysis and clinical findings.

Hot Temperature↗