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Biomedical subjects

K Gärtner

Publications and source records attributed to K Gärtner.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Yersinia enterocolitica infections in Southwest Germany. A report on 580 bacteriologically confirmed cases (author's transl)].

The bacteriological, epidemiological and clinical aspects of human Yersinia enterocolitica infections are discussed with reference to 580 first isolations of Yersinia enterocolitica made from 1972 to 1980 with routine procedures for salmonella/shigella diagnosis, predominantly from stool samples of patients suffering from gastrointestinal diseases.

Bacteriological Techniques↗
PubMed1980

Determination of renal plasma flow by endogenous hippuric acid clearance in the conscious rat.

(1) The endogenous hippuric acid can be fluorometrically determined down to a minimum of 0.6 micrograms/ml in 10 microliters of rat serum. This enables the determination of the effective renal plasma flow (ERPF) by measurement of the renal clearance of the endogenous hippuric acid in the conscious rat. (2) Endogenous hippuric acid clearance (128 ml/min . m2 or 2.48 ml/min/100 g body weight) corresponds in its extent with the clearance after a single injection of unlabelled hippuric acid and is higher (20%) than the clearance after a single injection of 131I-hippuran. (3) Exogenous hippuric acid has a short biological half-time of 12-20 min and a distribution space of about 50%; therefore, alteration of its intermediary supply can disturb the estimate of the renal clearance of endogenous hippuric acid. (4) The daily rhythm of the renal excretion of endogenous hippuric acid shows a constant low excretion between 0800 and 1200 hours; this period is the best suited for clearance measurements.

Animals↗
PubMed1980

Renal handling of albumin: clearance studies with bovine and rat serum albumin in conscious rats.

The reabsorption capacity of albumin was determined by a clearance technique following a single load of bovine or rat serum albumin in conscious rats. The maximum reabsorption capacity of both albumin amounted to 5.6--6.2 micrograms/min . 100 g BW and there seemed to be a nonselective mechanism for the two albumins. The tubular reabsorption capacity was reached at normal physiological plasma albumin concentration. The renal excretion threshold of both albumins amounted to 31.8 mg/ml, the sieving coefficient phi was calculated to be 2.0 . 10(-4). The glomerular filtration rate, controlled by the total plasma slope clearance of 51Cr-EDTA, remained unchanged following a load of rat serum albumin (54.8 +/- 12.2 ml/min . m2 body surface) but decreased significantly after the administration of bovine serum albumin.

Albuminuria↗
PubMed1980

Sex differences in kidney morphology and glomerular filtration rate in mice.

The relative kidney weight (1.44% greater than 1.15% greater than 1.07%) and the GFR (44 greater than 39 greater than 35 ml/min . m2) are higher in adult males than in adult females or in orchiectomized males. In contrast, GFR based on kidney weight is smallest in healthy males (1.02 less than 1.22; 1.22 ml/min . g). Only the cortex tissue seems to be increased in males, because its width (1.67 mm) is greater than in females (1.26 mm), while medullary width is identical (2.4 mm) in both sexes. Enlargement of the cortex in males can be accounted for by the nonglomerular tissue, because glomerular diameters (120 micrometers) do not differ and the number of glomeruli in representative sections is lower than in females. Cuboidal cell transformation of the outer layer of Bowman's capsule was observed in 60% of the glomeruli of the males and in 5% of the females. It might be an indicator for hyperplasie of the proximal tubular cells in the males.

Animals↗