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Biomedical subjects

K Günther

Publications and source records attributed to K Günther.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Quantitative measurement of arterial flow by means of directional Doppler technic in hemodynamic animal experiments].

The usability of the continuous ultrasonic Doppler-method for the measurement of the blood flow in the haemodynamic animal experiment was tested. For this purpose measurements at the ascending aorta and the commune carotid artery were performed on different current conditions and compared with the electromagnetically registered blood flow. The causes for the non-conformity are discussed.

Animals↗
PubMed1979

[Index of isometric contraction--a comparison with invasive methods of cardiac function testing in patients with ischemic heart diseases and post-myocardial infarct status].

In 81 patients with an ischaemic heart disease and myocardial infarction the evidence of the presphygmic index PI (non-invasive index) was tested concerning a beginning myocardial functional disturbance and a latent heart insufficiency, respectively, with the help of an invasive cardiopulmonary functional diagnostics which was performed under dosed bicycle ergometer load in the steady state. The presphygmic index PI correlates in significantly positive way with the end-diastolic pressure of the heart and the quotient from minute volume of the heart and the end-diastolic pressure of the pulmonary arteries (VM/PAEDP). The presphygmic index is on the basis of this correlation of the left-ventricular function suitable to establish disturbances of the myocardial functions and to give the possibility of a separation of the patients in cardially sufficient and cardially insufficient ones. Here the evidence of the presphygmic index might be larger concerning the recognition of a latent heart insufficiency than concerning the recognition of beginning myocardial functional disturbances. The presphygmic index apparantly possesses a high degree of sensibility then, when the myocardial functional disturbances coincide with a beginning reduction of the pumping action of the heart.

Adult↗
PubMed1979

[Some problems of Wilson's disease].

The Leipzig Center for Wilson's Disease in the GDR is charged with the registration and diagnosis of all homozygous Wilson gene carriers, the clarification of all suspected cases, including the heterozygote test, and the co-ordination of long-term treatment. At present, there are 78 recorded Wilson gene carriers living. On the basis of our own comprehensive observations and investigations over prolonged periods of time, questions concerning pathogenesis, genetics, diagnosis and therapeutic measures, including their side-effects, are dealt with.

Adolescent↗
PubMed1978

[The application of a radionuclide technique for uroflowmetry and determination of residual urine in gynecology (author's transl)].

The micturition of 74 female patients with different disturbances of bladder voiding was studied using 99mTc-DTPA and a gamma camera connected to a cinescintigraphic system and a small computer. The urinary flow and the residual urine were determined from the voided urine volume and from the time-activity curves and the residual counting rate respectively recorded over the bladder region. The values of normals are compared with those found in different types of incontinence and neurogenic micturition disorders. The method provides important parameters of the dynamics of bladder voiding without unphysiologic manipulations. The costs are very low if the standard equipment of a nuclear medicine department can be used.

Female↗
PubMed1978

[A programmed universal stimulator for the diagnosis and therapy of bradycardial and tachycardial arrhythmias].

Special kinds of electrostimulation, particularly the so-called programmed stimulation, are necessary for the specialised diagnostics of disturbances of nervous impulses of the heart and of the conduction system with intracardiac ECG (His-electrocardiography). A pacemaker using constituents of microelectronics is described which apart from fixed frequent, coupled, P/R-linked, bifocal and higher frequent atrial stimulation makes possible a programmed stimulation according to a preelected programme. Apart from the use for diagnostics the stimulator is suited for the therapy of bradycardic disturbances of the rhythm and for the termination of tachycardias.

Bradycardia↗
PubMed1978

[The effect of early appearing extrasystoles on systemic and coronary circulation].

In 10 anaesthesized dwarf pigs with an open thorax the effects of extrasystoles on systemic and coronary circulation were investigated. The actual effect of an extrasystole depends on the time of its onset. Early extrasystoles hamper the cardiac blood perfusion, with decreases in the stroke volume, mean arterial pressure, coronary blood flow, and elevation of coronary resistance. Extrasystoles setting on later are of minor haemodynamic and coronarodynamic importance. The effects of bigeminy and 2:1 extrasystolia are more adverse than the consequences of extrasystoles with later onset. With cumulation of several consecutive extrasystoles also adverse the haemodynamic coronarodynamic sequelae increase, in dependence on the magnitude of the quotient coupling time /extrasystolic excitation period [ greater than 1.1], or of the quotient: duration of pre- and postextrasystolic intervals/ normal interval of heart action [ greater than 1.5]. The authors point out the importance of haemodynamic findings during early extrasystoles in ischaemic heart disease.

Animals↗
PubMed1977

[The effect of cardiovascular hypertrophy on the work capacity of hypertensive patients].

Hypertensive persons with pathological ECG in rest compared with healthy persons and hypertensives with normal ECG in rest show a significantly decreased physical efficiency. In hypertensives in stage II disturbances in form of references to a stress heart insufficiency, to a stress coronary insufficiency and a circulatory dysregulation are the cause of the disturbed function of the circulation. Thus the pathological ECG in rest in the hypertensive is an important diagnostic and prognostic criterion for practice.

Blood Pressure↗
PubMed1977

[Behavior of cardiopulmonary function in hypertonics under ergometer load].

In 56 male hypertensive patients a complex cardiopulmonary functional diagnosis was performed in rest and under ergometer load. The total functional capacity of the hypertensive patients is decreased already in the early stage and also in juvenile age, compared with healthy persons. Furthermore disturbances of the regulations of the minute output of the heart, hypertensive stress reactions, disturbances of the coronary blood supply and disturbed functions of the myocardium are provable.

Adult↗
PubMed1976

[Importance of continuous recording of vascular resistance].

The behaviour of resistance in the periphery of the circulation and in the organic regions underlies different influences. Depending on the function of the organs, on the situation of heart and circulation and on the therapeutic influences the vascular resistance changes. To the study of the dynamics of the behaviour of resistance particularly the continuous electronic recognition is suitable. The gain of time and information is great. Especially for the determination of the coronary perfusion in different functions of heart and circulation the continuous registration of the vascular resistance is necessary. Its importance was as an example demonstrated for the left-ventricular ejection resistance and for the left- and right-coronary influx resistance.

Animals↗
PubMed1976

[Assessment of the coronary circulation regulation by means of the so-called isometric contraction index].

The index of isometric contraction formed from the quotient period of isometric contraction in the erect position by period of isometric contraction in lying position gives the possibility to separate between cardially sufficient and cardially insufficient patients with adequately disturbed regulation of the cardiac circulation. The recognition of early stages of the disturbed left-ventricular function is possible. The use of an adequate exact technique in gaining the primary data is to be presumed. Corrections of the frequency of the index of isometric contraction do not improve the evidence. In the borderline region of the index of isometric contraction with values between 1.03 and 1.1 in questionable cases a further differentiation into still normal or already latent insufficient will do by the analysis of the trend of the index of isometric contraction after the application of medicaments. The determination of the change of the direction of the index of isometric contraction after peroral application of nitroglycerin would be justifiable in routine work after the recognition of the initiaction increases in patients with latent heart insufficiency, in patients with a healthy heart it decreases. The clinical value of the index of isometric contraction as a simple test of the circulatory function is highly to be estimated.

Coronary Circulation↗
PubMed1976

[Vetorial presentation of left-ventricular pressure parameters for the assessment of ventricular function].

The ventricle function can be established by the vectorial description of left-ventricular pressure parameters or flow sizes, respectively. The vector diagrammes result from the momentaneous pressure within the ventricle on the X-axis and the differentiated pressure curve or the aortic flow, respectively, on the Y-axis. Well surveyable from the vector loop received (LVP/dp/dt) are established dp/dtmax, dp/dtmin, LVPmax, LVEDP as well as the tg of the pressure increase speed or the pressure decrease speed, respectively, pro developed pressure. By way of example medicamentous changes of the vector diagrammes were induced and the parameters mentioned established. The vectorial demonstration of the left-ventricular haemodynamics seems to give additional informations concerning the phase of centraction and relaxation

Adrenergic beta-Antagonists↗
PubMed1976

[Electronic processing of intravascular by measured blood pressure].

With the help of electronic processing of measurement values the possible information content of the dynamic blood pressure measured by means of the electromanometer is explained. Commericial writing systems and pressure changers are supplemented by self-constructed and especially dimensioned additional devices. Partly in connection with flow sizes by multiplication, division, addition, subtraction, differentiation and integration from pressure values special references to the behaviour of the haemodynamics of certain parts of the circulation are to be obtained. This is explained by examples. In addition to this the authors deal with the systolic and diastolic indication of blood pressure important for haemodynamic measuring programs, with the electronic mean value formation, with the limitaor connection for the indication of the enddiastolic ventricular pressure as well with the short-term accumulation. The electronic processing of the intravasally measured blood pressure as well as of flow values is necessary for analyses of the circulation.

Blood Pressure↗
PubMed1976

[Cardiopulmonary diagnosis in patients with ischemic heart disease].

It may be established that the complex cardiopulmonary functional diagnostics in patients with chronic ischaemic heart disease obtained the following essential results: 1. The ergometrically achieved total functional capacity is clearly decreased in all age groups compared with the healthy persons, the differences are highly significant. 2. The proof of a coronary insufficiency got by the electrocardiogram after work is to be regarded as a factor limiting the functional capacity. 3. 72% of the patients reveal under load a PAEDP increased more than the normal of 25 Torr. After exclusion of a respiratory insufficiency these findings must be regarded as a disturbed myocardial function. 4. Thus the increased PAEDP under load apart from the well-known triad (angina pectoris under load, decreased total functional capacity, pathological ECG after work) is a sensitive and decisive factor for proving the disturbed cardial function in chronic ischaemic heart disease.

Adult↗
PubMed1976

[The value of the diastolic pulmonary arterial pressure for the estimation of the cardiac functional capacity in patients with myocardial infarct].

From 4 weeks to several months after infarction the patients revealed an altogether clearly decreased total physical functional capacity compared with healthy persons. Behaviour of pulse and blood pressure as well as ventilatory indices in comparable Watt-degrees did not reveal any significant differences compared with persons with a healthy heart. The stroke volume pro surface and the heart-time-volume did also not reveal any determinable deviation concerning the mean values compared with normal persons. In patients with compensated infarction the pulmonary arterial pressure in rest was, as a rule, within the normal. However, under load it increased more than in healthy persons. Patients with decompensated infarction revealed a PAEDP in rest between 20 and more than 30 Torr. The question about a critical PAEDP under load should further be pursued. The ECG gives reliable limiting findings in functional examinations.

Adult↗