PubMed Health⌕ Search

Biomedical subjects

K Gałazka

Publications and source records attributed to K Gałazka.

8 recordsLinked to original sources
PubMed2003

History and current status of Polish gastroenterological pathology.

The present paper summarizes the contribution of Polish investigators to the development of gastroenterology, and especially pathology of the gastrointestinal tract. We called to mind meritorious scientists among the 19(th)-century and modern pathologists. Especially interesting are discoveries of Browicz, being the first, who described typhus bacilli and shortly after Kupffer - fagocytozing cells in the liver. Noteworthy are detailed description of tumorous lesions being the contribution to oncological pathology of the gastrointestinal tract as well as the reports on congenital malformations (i.e. esophageal fistulas). Moreover we remind the investigators dealing with pathology of gastric ulcer disease, its pathogenesis and mechanisms of healing. Of great importance was also the discovery of regeneration existing also outside the mucosal surfaces. In the paper, besides the above-mentioned Tadeusz Browicz investigations of professors: Leśniowski, Ciechanowski, Kowalczykowa, Stachura, Konturek are called to mind.

Gastroenterology↗
PubMed2001

Evaluation of the proliferative activity as an adjuvant helpful tool in the diagnosis of primary gastric lymphoma in gastrobiopsy.

Gastrobiopsy specimens obtained from 15 patients, in whom gastroscopy examination pointed to gastric cancer and primary gastric lymphoma was later diagnosed in surgical material after gastrectomy, were immunostained using the anti MIB-1 antibody to assess the proliferative index. A control study was carried out on representative surgical specimens from these patients and on 10 gastrobiopsy specimens from patients in whom histopathology revealed moderate/severe gastritis. The proliferative activity was assessed with respect to the type of lymphoma (primary gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue MALT type vs. diffuse large B-cell lymphoma) and stage of the lymphoma, and we compared the proliferative indices between inflammatory infiltrate and lymphoma cells. There were significant differences in the proliferative indices between inflammatory infiltrate and lymphoma cells, with immunohistochemical reactivity for MIB-1 antigen being visible even in the case of markedly mechanically damaged (crushed) gastrobiopsy material and accompanying necrosis. There were also differences in the proliferative indices between the groups of lymphomas varying in stage, although without statistical significance. There were no statistical differences in the rate of proliferation between lymphomas varying in "malignancy". The present results argue for the auxiliary role of the assessment of proliferative activity in gastrobiopsy material facilitating differentiation between inflammatory infiltrate and neoplastic infiltrate, especially in cases where mechanical damage or necrosis do not allow for precise histopathological evaluation.

Adult↗
PubMed2000

Factors associated with progression of primary gastric marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT type).

Sixty cases of primary MALT type lymphomas were subjected to a retrospective analysis, which assessed the proliferative (PI) and apoptotic (AI) indices. The MIB-1 antibody was used for the Ki-67 proliferative antigen epitope, as well as the Apoptag In Situ Apoptosis Detection Kit (Oncor). The group included 32 low-grade and 28 high-grade lymphomas. In addition, the high-grade lymphomas group was divided into subgroups, depending on the presence or absence of a low-grade component. Significant differences were demonstrated in proliferative and apoptotic indices for cases differing with respect to their histological grade and stage. In low-grade lymphomas, the increase of AI value was associated with the increase of blast cells in the neoplastic infiltrate. It was necessary to exclude from this group cases of intensified plasmocytic differentiation, as such intensified differentiation alone was associated with increased AI values also. Considerable variations were noted in AI and PI values, even in groups with the same histological grade. The results suggest a potential clinical importance of AI and PI evaluations, stressing the necessity of treating each case of primary MALT type lymphoma individually. It appears that histological grade and stage evaluation alone may be insufficient when planning the management and prognosticating the response to therapy.

Adult↗
PubMed2000

Epithelial-myoepithelial carcinoma of the bronchus.

The authors describe an extremely rare case of epithelial-myoepithelial carcinoma of bronchial mucous glands involving lower lobe of the right lung, which was detected on a routine radiological examination in a 34-year-old woman, and then surgically resected.

Actins↗
PubMed1999

Primary localized cutaneous amyloidosis--lichen amyloidosus. A case report.

We report a case of primary localized cutaneous amyloidosis-lichen amyloidosus in a 55-year-old man. Immunohistochemistry using antibodies against cytokeratin and AL immunoglobulins revealed the presence of both components in amyloid foci located subepidermally, mainly in dermal papillae. The results of histochemical reactions confirm the keratin-derived nature of amyloid in primary cutaneous amyloidosis.

Amyloid↗
PubMed1997

Synchronous carcinoma and primary MALT-lymphoma of the stomach. A report of two cases.

A synchronous presentation of an adenocarcinoma and a primary low grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) in the stomach is reported in a 73-year-old woman and a 55-year-old man. The diagnosis was based on microscopic examination of surgical specimens with immunohistochemistry. A possible etiology of the simultaneous presence of these two neoplasms in the stomach is discussed on the basis of our own material and review of the literature.

Adenocarcinoma↗
PubMed1997

Gastric fundic gland polyps (Elster's polyps) and Helicobacter pylori-induced gastritis.

In a series of 555 gastric polyps characteristic Elster's polyps were identified in 31 cases. Spiral bacteria (Helicobacter pylori) in these polyps were sporadic, much less frequent (9.7%) than in hyperplastic polyps (35%) in the present series and in relation to the bacteria frequency found in our randomly chosen gastric biopsy specimens (43%). The present results indicate that Elster's polyps are not readily colonized by Helicobacter pylori and accordingly, they do not show the signs of active gastritis. The reasons for this are unknown. One of the mechanisms preventing from bacterial colonization may be a different from normal gastric mucosa and other polyps character of mucus produced by glandular neck cells, which was found in our series of gastric fundic gland polyps.

Adolescent↗