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Biomedical subjects

K Gabryś

Publications and source records attributed to K Gabryś.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Non-homogeneity of serum leucine arylamidase (LAP) activity in hepatocellular and obstructive jaundice.

In 40 patients with hepatocellular and obstructive jaundice and in 20 healthy subjects the pattern of serum leucine arylamidase (LAP) isoenzymes was determined. Polyacrylamide gel electrophoresis was used for demonstration of enzyme non-homogeneity. It was found that the main enzyme activity in healthy subjects was connected with postalbumins. In some healthy subjects and additional zone of activity was observed in beta lipoproteins. Only exceptionally 3- and 4-fraction enzymograms were found in healthy subjects. Additional activity zones were present in these subjects in the alpha2 macroglobulin region or in the region of slowly migrating haptoglobins. In hepatocellular jaundice, i.e. in viral hepatitis, the total serum LAP activity increased slightly. In the enzymogram this increase was localized in the postalbumin fraction and caused also appearance of additional, sporadically occurring isoenzymes migrating with rapidly moving haptoglobins. In obstructive jaundice of benign or malignant etiology the total serum enzyme activity rose strikingly. In most patients a 6-fraction enzymogram was found. The activity of postalbumin isoenzyme was particularly increased, while no changes were observed in the remaining activity zones sporadically occurring in healthy subjects and in hepatocellular jaundice.

Adult↗
PubMedDate not supplied

Non-homogeneity of serum alkaline phosphatase activity in certain diseases of the liver and bile ducts investigated by polyacrylamide electrophoresis.

In 47 patients with hepatocellular or obstructive jaundice and 20 healthy controls the alkaline phosphatase isoenzyme pattern was determined by means of electrophoresis on polyacrylamide gel. It was demonstrated that the main activity of alkaline phosphatase (AP) in healthy subjects was connected with beta globulins while beta lipoproteins contained only traces of this activity. In hepatocellular jaundice during viral hepatitis only a slight rise was found of the activities of isoenzymes present in healthy subjects, and no zones of additional activity were found. In obstructive jaundice of benign as well malignant etiology the beta lipoprotein zone increased also significantly, moreover an additional activity zone was revealed moving in the gel together with alpha2macroglobulins. In 40% of cases of obstructive jaundice caused by metastatic malignant neoplasms in the liver a 4-fraction isoenzyme pattern of AP was demonstrated with additional activity in the haptoglobin zone.

Adult↗
PubMedDate not supplied

[Comparison of the effectiveness of metoclopramide and dexamethasone in the prevention of cytostatic-induced vomiting].

Efficiency of anti-emetic properties of metoclopramide and dexamethasone was compared. Both drugs were administered to 22 patients with newly diagnosed untreated previously Hodgkin's disease during ABVD therapy. Number of vomiting episodes, nausea intensity and everyday patients' activity on the day of cytostatics administration were evaluated. Metoclopramide prevented vomiting in 55% of patients while dexamethasone in 65%. This difference was statistically insignificant. Patients' everyday activity was statistically significantly more frequently normal in patients receiving dexamethasone in comparison with placebo and decreased in patients receiving metoclopramide. Therefore, patients preferred dexamethasone.

Adolescent↗