PubMed Health⌕ Search

Biomedical subjects

K Gail

Publications and source records attributed to K Gail.

At least 19 recordsLinked to original sources
PubMed1991

Failure of ranitidine and omeprazole treatment in eosinophilic gastritis with ulceration.

In a 32-year-old woman with an ulcer that had persisted for more than 13 months despite treatment with the H2 blocker ranitidine, the latter was replaced by the H+K(+)-ATPase inhibitor omeprazole. Treatment with omeprazole also failed to bring about healing of the ulceration which, at times, measured up to 10 cm in diameter. On account of a hemorrhage from the ulcer, a Billroth II resection of the stomach had to be performed. The histological work-up of the surgical specimen confirmed the tentative diagnosis of a secondary ulceration in underlying eosinophilic gastritis established on the basis of the work-up of biopsy material obtained from the ulcer. The reason for the failure of the lesion to respond to the H2 blocker or omeprazole in this case was a diffuse infiltration of the antral wall with eosinophilic granulocytes, and the resulting secondary persistent ischaemic ulceration.

Adult↗
PubMed1983

[Malignant extrahepatic bile duct occlusion. Diagnosis and palliative treatment].

A diagnosis of malignant extrahepatic biliary obstruction was made in 123 cases by endoscopic retrograde cholangio-pancreaticography (ERCP) and (or) percutaneous transhepatic cholangiography (PTC). The diagnosis was confirmed by operation, biopsy or autopsy or further investigations and follow-up. The diagnosis was correct in 96% and false in only 4%. Clinical and biochemical findings were unreliable. Ultrasound investigations were accurate in 94% of cases with malignant obstruction low down. However, it was negative in cases with high obstruction in 19% due to the absence of dilatation of the intrahepatic biliary ducts. Consequently these cases could not be diagnosed without additional ERCP and PTC. ERCP and PTC also permit palliative treatment to be done. In 30% of all cases a palliative non-surgical treatment was performed such as endoscopic sphincterotomy with or without endoprosthesis or percutaneous transhepatic drainage.

Adult↗
PubMed1983

Palliative treatment of inoperable patients with carcinoma of the cardia region.

Endoscopic palliative treatment of inoperable patients with carcinoma of the cardia region is superior to surgical procedures that allow the feeding of patients. After dilating the malignant stenosis with an Eder-Puestow dilator, a Celestin or Atkinson tube is inserted endoscopically by means of the Nottingham introducer. In 25 of 26 patients the inserted tube functioned well until the death of the patient for an average of 109 days. Six patients are still alive and one patient has had the tube for almost 3 years. Of the 19 patients who died, 18 retained the tube until they died. The complication rate of the procedure was 11.5% with a 3.8% mortality related to tube insertion.

Adenocarcinoma↗
PubMed1983

Gastric polypectomy. Long-term results (survey of 23 centres in Germany).

In a survey of 23 endoscopy centres in the Federal Republic of Germany 6,182 cases are reported in which gastric polypectomies were performed. 1,177 patients were observed over a period of up to 7 years. Primary benign gastric polyps recurred in 6.1% most of them within 1 year after polypectomy, and genuinely recurrent polyps usually had a histological pattern identical to that of the ectomized polyps. In 32.5% new polyps occurred at different locations in the stomach, and most of them exhibited the same histological structure as the primary polyp. In 1.7% of primary benign solitary or multiple gastric polyps gastric carcinoma must be expected to develop. Follow-up examinations revealed only one carcinoma in 68 polyposis patients (= 1.5%), but in these cases, consideration must be given to a simultaneous carcinoma, which was observed in 8.5% at the first examination. In high-risk patients, endoscopic removal of protruded-type early gastric cancer and borderline lesion represents very satisfactory therapy. The recurrence rate of early gastric cancer was only 13.6% and of borderline lesion 9.7%. However, in cases of borderline lesions a cancer can be expected to develop in a further 8.6%. The consequences of this study are discussed.

Endoscopy↗
PubMed1982

[Long term results after endoscopic sphincterotomy].

A multicenter study of 25 centers covering 9041 endoscopic sphincterotomies showed that choledochal concrements still represent the main indication (83,9%). Circumscript papillary stenosis (10.64%) and papillary tumour(2.06%) are the next most frequent indications. Complications after endoscopic sphincterotomy may be expected in 7.55% of cases, somewhat more frequent after papillary stenoses than after choledochal concrements. The most frequent complication is haemorrhage, followed by pancreatitis, cholangitis in cases of choledochal concrements, and perforation. Mortality is around 1.12%. Late results after endoscopic sphincterotomy a satisfactory and concrement-free bile ducts are seen in 91.62%. Freedom of complaints or improvements of symptoms occur in 93.4%. Recurrent stones occur in 5.77%, restenoses were seen in 3.14%. Late results after endoscopic sphincterotomy ar worse in papillary stenosis than in choledocholithiasis. Mortality figures are twice as high and danger of perforation seems to be more frequent. Endoscopic sphincterotomy is done increasingly as an emergency measure.

Ampulla of Vater↗
PubMed1979

Diagnosis of early gastric cancer.

Early gastric cancer is being encountered with increasing frequency in Germany as well as Japan and elsewhere through greater awareness, selection of high risk patients and improved diagnostic methods. We consider endoscopy superior to radiology in the detection of early gastric cancer. Polypoid lesions of the stomach need endoscopic biopsy or removal for proper diagnosis. Gastric ulcers should be followed by endoscopy and guided biopsies until healing is complete. Adequate sampling of a suspected gastric lesion may require multiple biopsy specimens for accurate histological interpretation.

Biopsy↗