Low dose cyclosporin A and methotrexate in the treatment of psoriasis.
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Biomedical subjects
Publications and source records attributed to K Georgouras.
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OBJECTIVES: To review the complications and contraindications associated with cutaneous cryotherapy, and to describe the prevention of complications by appropriate technique, with consideration of the type of lesion being treated, the anatomical site and recognition of the high-risk patient. DATA SOURCES AND SELECTION: We reviewed published work (in English) from 1982 to 1993. All commonly cited complications are presented and described. CONCLUSIONS: Cutaneous cryotherapy generally has few complications. However, serious adverse events have been reported, and should be noted by all clinicians using cryotherapy. With adequate training, appropriate patient selection and the use of suitable cryotherapy regimens, cutaneous cryotherapy provides safe and effective treatment for a wide variety of cutaneous lesions.
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We report the case of a 76 year old man with three ulcerated basal cell carcinomas on his lower limbs. He was considered unsuitable for surgical therapy and was treated by intralesional interferon alpha-2b (Intron A) injections. Twenty months post therapy two of the three treatment sites remain clinically cured. Recurrence occurred at the site which received the smallest total dose of interferon. A review of the therapeutic trials of interferon alpha for basal cell carcinoma is presented. We conclude that interferon alpha-2b is a useful agent for treatment of basal cell carcinoma in selected patients.
A case is presented of a Sweet's syndrome-like eruption in association with the oral contraceptive. A 46 year old caucasian woman developed recurrent episodes of erythematous tender plaques on her trunk six weeks after commencement of the oral contraceptive (OC). Her condition clinically and histologically resembled Sweet's dermatosis. On cessation of the OC there was complete resolution of her lesions and she remains well 12 months later. This is the first report, to our knowledge, of a neutrophilic reaction to the oral contraceptive, and we believe that drugs may be implicated in the aetiology of atypical neutrophilic reactions simulating Sweet's syndrome in patients who are otherwise well.
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The case is described of a boy aged 13 years reported with a diffuse facial micropapular eruption which had a granulomatous histology. The diagnosis is consistent with perioral dermatitis of the Gianotti type (4, 5). It is postulated that bubble gum was the cause of the condition, the most likely ingredient being the essential oils in the gum, which may actually be selectively absorbed by the follicle to produce a perifollicular granulomatous reaction. In this article we have added yet another possible cause for perioral dermatitis.
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