PubMed Health⌕ Search

Biomedical subjects

K Gerber

Publications and source records attributed to K Gerber.

At least 37 records · Page 2Linked to original sources
PubMed1981

The value of nuclear bone imaging in advanced prostatic cancer.

The nuclear bone scan is a highly sensitive means of detecting skeletal metastasis in patients with prostatic cancer. Serial bone imaging provides an accurate method to follow the response of osseous metastases to treatment and to detect relapsing disease in the skeleton. In selected instances the nuclear bone scan can provide information about vertebral metastases that can be important for planning palliative treatment of pain.

Bone Neoplasms↗
PubMed1981

Agreement in human interpretation of analog thallium myocardial perfusion images.

To assess the agreement of human interpretation of analog thallium myocardial perfusion images, four experienced interpreters evaluated 100 images on two occasions using a form designed to limit reader variability. A high intraobserver agreement (agreement by same observer at separate times) of 89--93% was found when films were interpreted as normal or abnormal (a dichotomous decision). Interobserver agreement for a majority grouping of observers (three or four) was 75% for an abnormal and 68% for a normal interpretation. However, agreement ranged from 11--79% when interpreters were asked to read the anatomic location of defects. Posterior and lateral wall defects were interpreted with the least amount of agreement. These results indicate that caution must be taken when interpreting defect location. Using a scale of 1--10 to grade the severity of a defect, correlations of 0.82--0.86 were found when reading defects in the lateral and anterior projections. Higher correlations, from 0.86--0.94, were found in left anterior oblique views. Use of reporting forms with specific criteria, multiple observers at one occasion, and/or computer processing may improve agreement. A brief review of the agreement of cardiology testing procedures is also presented.

Angina Pectoris↗
PubMed1981

Left ventricular size and function after subcutaneous administration of terbutaline.

To assess the response of the left ventricle to subcutaneously administered terbutaline sulfate, a proposed beta-2 selective agonist, we evaluated 12 patients who had suffered previous myocardial infarctions using equilibrium radionuclide angiography. Six patients (group 1) had normal global left ventricular ejection fraction at rest less than 0.49). All patients had a marked decline in end-diastolic volume and end-systolic volume with a significant (P less than 0.01) increase in ejection fraction after terbutaline injection. Cardiac output increased 30 percent in group 2 patients because of an increase in stroke volume, with little change in heart rate (plus or minus 3.1 beats per minute, P equals NS). Cardiac output increased 7 percent in the patients in groups 1, due primarily to an increase in heart rate in 7 beats per minute (+9 percent) with little change in stoke volume. Systemic vascular resistance decreased significantly more in the patients with compensated heart failure than the subjects in group 1 (342 plus or minus 84 vs 90 plus or minus 35 dynes-sec cm(-5), P less than 0.05). We conclude that terbutaline exerts its most beneficial effect on the left ventricle in patients with depressed resting global function, and may prove to be a useful agent in the treatment of congestive heart failure.

Aged↗
PubMed1980

[The professional and familial status of female physicians in Switzerland].

A questionnaire on professional and family life was sent to all women doctors in Switzerland (N=2570). 70% were returned, 80% of the respondents are exercising their profession, though only 50% in full time jobs. The most important reason for not working is the presence of small children, mainly in doctors aged 30-40.

Adult↗
PubMed1980

Radionuclide perfusion images before and after cardiac rehabilitation.

Improvement in cardiac perfusion has not been demonstrated in man to explain the increased functional capacity secondary to exercise training. Thallium imaging is a noninvasive method of evaluating myocardial perfusion and scaring. Therefore, using thallium exercise tests, we studied 17 patients with coronary heart disease before and after a mean of 6 months participation in cardiac rehabilitation program emphasizing exercise training. Interobserver variability in imaging interpretation was considered by reading images blinded both individually and in consensus. Agreement with defects called by consensus occurred at least 51% of the time individually and normal readings agreed at least 90% of the time. By consensus reading, seven patients showed improved perfusion, seven showed no change, and three worsened following training. Our study shows that thallium scans may be used to demonstrate central changes in myocardial perfusion after cardiac rehabilitation, but larger controlled studies considering redistribution and utilizing image enhancement are necessary to see if such changes are truly secondary to this intervention.

Adult↗
PubMed1980

Cardiac rehabilitation: evidence for improvement in myocardial perfusion and function.

Sixteen patients with coronary heart disease (CHD) were studied with rest and exercise thallium scans and gated radionuclide ventriculography before and after 3 to 12 months of exercise training. The 5 patients presented in this report showed improvement in both the ejection fraction and exercise thallium images after training while achieving a higher maximal workload and an equivalent double product. These radionuclide techniques have provided the 1st documentation of improvement in both myocardial perfusion and function in CHD patients after exercise training. A controlled study using advances in imaging technology with patients matched according to postmyocardial infarction time and by the severity of disease is underway to confirm these findings.

Adult↗
PubMed1975

The interaction of cobalt (II) complexes with bovine apocarbonic anhydrase B.

The second-order rate constants for interaction of a number of cobalt(II) complexes (including the aquated ion) with bovine apocarbonic anhydrase have been measured at pH equal to 7.5, 25 degrees C and I equal 0.1 M. The ease of entry of cobalt decreases, in general, as the number of its coordinated watersdecreases. The highest complexes (bis or tris) do not react. The Mono cobalt(II) -8-quinolinol-5-sulfonate and, particularly, 8-quinolinol complexes react very much more rapidly with apoenzyme than does Co(H20)6-2+ ion. The results are discussed.

Animals↗
PubMedDate not supplied

Pulmonary blood volume: correlation of equilibrium radionuclide and dye-dilution estimates.

In fifteen prospective patients with aortic stenosis undergoing transseptal cardiac catheterization, dye-dilution and count-based estimates of pulmonary blood volume (PBV) were performed. Three radionuclide methods were evaluated. Two were based on electrocardiogram (ECG)-gated imaging of the thorax, where pulmonary counts (PC) were corrected for frame-time, venous radioactivity, and either (1) the number of processed heart beats or (2) the total duration of acquisition. The third method involved ungated frame mode acquisitions, where PC were corrected for the duration of acquisition and the venous activity. PC (per channel element) were derived from manual assignments of the right lung. All methods correlated well with standard dye-dilution techniques (r greater than 0.82), though at greater volumes it was clear that count-based methods underestimated the dye-dilution values. In five acutely instrumented, anesthetized dogs, radionuclide (ungated formula) and dye-dilution estimates of PBV were made during multiple interventions (19 data points). The five control count volumes as well as the 14 separate intervention points correlated well (r greater than 0.89). It is concluded that PC from equilibrium blood pool images reflect PBV and that induced changes in PC can be utilized as a reflection of changes in PBV.

Adult↗