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Biomedical subjects

K Ghose

Publications and source records attributed to K Ghose.

63 records · Page 4Linked to original sources
PubMed1976

Mianserin hydrochloride: a novel antidepressant.

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.

Adjustment Disorders↗
PubMed1976

Clinical and pharmacological effects of treatment with a new antidepressant.

The novel tetracyclic piperazino-azepine compound Org GB 94 (Tolvon, Tolvin) in a dose of 20 mg three times daily was found to be of save markedly and significantly less side-effects. Patients with reactive depression and those with endogenous depression reponded equally well to Org GB 94. No correlation was found between plasma levels of Org GB 94 and either clinical effects or side-effects. Org GB 94 did not alter the tyramine pressor response, in contrast to amitriptyline.

Adjustment Disorders↗
PubMed1975

Intravenous tyramine pressor response in depression.

Tyramine-dose/pressor-response curves have been determined in 27 control subjects and 19 patients with primary depressive illness. In the depressive group, significantly lower doses of tyramine were required to elevate the systolic blood-pressure by 30 mm. Hg.

Adult↗
PubMedDate not supplied

Measurement of renal functions by double isotope techniques in elderly patients during tenoxicam therapy.

Four elderly patients (aged 68-87 yr) with osteoarthritis were treated with 20 mg of tenoxicam (a new non-steroidal anti-inflammatory drug) daily for at least 12 weeks. Tenoxicam did not appear to have any harmful effect on glomerular filtration rate and effective renal plasma flow, as measured by a single intravenous injection of 51Cr-EDTA and 125I-iodohippurate. Plasma concentration of tenoxicam indicated good compliance, and no evidence of unexpected accumulation of tenoxicam in the plasma was observed during 12 weeks of medication.

Aged↗
PubMedDate not supplied

Tolerance and side-effects of paroxetine in elderly depressed patients.

Paroxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, is considered to have fewer side-effects than a typical tricyclic antidepressant. As the elderly frequently suffer from adverse effects of psychotropic drugs, safeties and tolerance of paroxetine and their relationship with dose were studied in a double-blind study. Sixteen nondashhospitalised depressed patients, aged 72-86 years, were recruited but 12 patients completed the study. Patients were randomly selected to receive either 15 mg or 30 mg paroxetine daily for 42 days in a double-blind study. A trained nurse made weekly home visits to monitor their medication and general conditions. Patients were assessed at the hospital on days 1, 7, 14, 28 and 42. There were four drop-outs during the first week of study due to lack of motivation, skin rash and upper gastrointestinal symptoms (n=2). Plasma levels of paroxetine showed a dose-related increase in concentrations and indicated a good compliance. At the dosages used, no changes in blood pressure, heart rate, salivary volume, visual choice reaction time, critical flicker fusion threshold and short-term memory were observed in these patients. However, there was a significant improvement in their subjective symptoms (as assessed by a symptom check list and Hamilton Rating Scale) in the 30 mg group, indicating a feeling of well-being.

Clinical Trial↗
PubMedDate not supplied

Neuropsychiatric reactions to nonsteroidal anti-inflammatory drugs (NSAIDs). The New Zealand experience.

The New Zealand Medicines Adverse Reactions Committee has been monitoring reports of adverse drug reactions (ADRs) since 1965. We wished to determine the numbers of voluntary reports of different types of ADR to all nonsteroidal anti-inflammatory drugs (NSAIDs) over a long time period and relate these to age. As the elderly are known to suffer from neuropsychiatric adverse effects of many drugs, we investigated neuropsychiatric reactions to NSAIDs to determine whether these were more commonly reported in the elderly. We counted all reported ADRs suspected to be associated with NSAIDs as well as selected types of ADRs reported from 1970 to 1989. These were divided into 5-year periods and 10-year age groupings. In each consecutive 5-year period there was a progressive increase in the numbers of all ADRs reported for all NSAIDs. This was particularly marked above 50 years of age, but the numbers were reduced above 80 years. Reports for females accounted for about two-thirds of all reactions. Not unexpectedly, alimentary and dermatological ADRs accounted for most reactions and were more common in the group above 50 years. Overall, neuropsychiatric reactions were the third most common ADR type reported. Their numbers increased with age and peaked in the 50 to 59 age group, with a sharp decline after 69 years. This age distribution paralleled that for all ADRs to NSAIDs. Although neuropsychiatric reactions to NSAIDs were reported in all age groups, they were not reported more commonly in the elderly. This study suggests that neuropsychiatric reactions to NSAIDs may be more frequent than is commonly believed.

Adolescent↗