Biomedical subjects

K Gingell

Publications and source records attributed to K Gingell.

3 recordsLinked to original sources

PubMed2002

Evidence that variation at the serotonin transporter gene influences susceptibility to attention deficit hyperactivity disorder (ADHD): analysis and pooled analysis.

Reduced central serotonergic activity has been implicated in poor impulse regulation and aggressive behaviour in animals, adults and also young children.(1,2) Two recently published studies have implicated variation at a polymorphism in the promoter of the serotonin transporter (5HTT; hSERT) in influencing susceptibility to ADHD.(3,4) Consistent with these results we have also found a trend for the long allele of the promoter polymorphism to influence susceptibility to ADHD in a sample of 113 ADHD parent proband trios (65 transmissions vs 49 non-transmissions, chi(2) = 2.25, P = 0.13). A pooled analysis of our, and these published results demonstrated a significant over representation of the long allele of the promoter in ADHD probands compared to controls (chi(2) = 7.14, P = 0.008). We have also examined two other 5HTT polymorphisms (the VNTR in intron 2 and the 3' UTR SNP). TDT analysis demonstrated preferential transmission of the T allele of the 3' UTR SNP (chi(2) = 4.06, P = 0.04). In addition, ETDT analysis of haplotypes demonstrated significant preferential transmission of haplotypes containing the T allele of the 3' UTR SNP with the long allele of the promoter polymorphism (chi(2) = 13.18, 3 df, P = 0.004) and the 10 repeat of the VNTR (chi(2) = 8.77, 3 df, P = 0.03). This study provides further evidence for the possible involvement of the serotonin transporter in susceptibility to ADHD.

Adult↗

PubMed1996

Autism and multiple pituitary deficiency.

We describe a 9-year-old boy who presented with abnormal development in language and social interaction. He also showed evidence of stereotyped behaviour, thus fulfilling all the criteria for an ICD-10 diagnosis of autism. This was associated with multiple pituitary deficiency. No case of autism associated with hypopituitarism has hitherto been reported. The authors discuss the evidence for linking the two conditions as opposed to accepting them as coincidental. In some studies of autism, anatomical and imaging studies have provided evidence of pathology in the limbic lobe. This lobe plays an essential role in the modification and expression of emotional reactions. Together with other areas, the limbic system sends outputs from the hypothalamus and from there to the pituitary. Our case illustrates a possible link between emotional expression and hypopituitarism.

Autistic Disorder↗

PubMed1994

A controlled community study of movement disorder in people with learning difficulties on anti-psychotic medication.

The results of a community-based study measuring the occurrence of movement disorders in a population of people with learning difficulties treated with antipsychotic medication are presented. This group was compared with an age- and sex-matched group with a similar degree of handicap, who were not treated with antipsychotic medication. When medication was given within British National Formulary Guidelines, no significant increase in movement disorders in the treated group was found. The relevance of this to psychiatric practice is discussed.

Adult↗