DNA-ploidy and the percentage of S-phase fractions in 55 primary oropharyngeal squamous epithelium carcinomas were measured by DNA-Flow Cytometry (FCM). The data were compared with the histologic grade, the stage and the response of the tumours to cytostatic chemotherapy. A significant correlation was found between the histologic grade and the mean percentage of S-phase fractions (p less than 0.01). No correlation could be found between the FCM measurement data and the tumour stage. Carcinomas with an amount from 4.0 to 10.4% S-phase fractions responded to chemotherapy by complete remission, and those with 10.0 to 13.3% S-phase fractions by partial remission. The group of non-responders could be subdivided into two subgroups: non-responders with low amounts of S-phase fractions (1.1-3.9%), and non-responders with very high amounts of S-phase fractions (11.6-16.6%). FCM data, histologic and clinical prognostic factors were summed up to a prognostic score. The number of score points showed a significant correlation to the length of survival in months after diagnosis of the tumour (p less than 0.00001). FCM may be used as an additional diagnostic tool for a better biological characterization of the neoplastic tissue, especially as an aid for grading, prediction of the response to chemotherapy and the length of survival.

Adult↗

PubMedDate not supplied

[What is cancer?].

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Humans↗

PubMedDate not supplied

[Pathologico-anatomic cancer diagnosis in the aged--principles and basic data].

The occurrence of various forms of cancer is generally more frequently observed in elderly persons. But this phenomenon is not correlated to or a consequence of the natural ageing process. In this study, observed frequencies of carcinogenesis within defined stages of the life cycle are presented. It was found that the dynamics of cancerogenesis is different with increasing age. The principle cancerogenetic effects are thought to occur ultimately at the genetic level in somatic cells. Therefore the specific compartmentalization of rapidly proliferating cells within individual tumors can be used as a criterion for diagnostics such as prognosis of tumor growth and correlation to the malignancy grading. In addition, it is emphasized that tumor diagnostics is particularly important for elderly persons in order to make the real value of early detection schemes accurate. The second part of the study concerns a catalogue of tumor localizations grouped for both sexes. For men this includes the respiratory tract, stomach, prostatic gland, large intestine, rectum, skin including melanomas, urinary bladder, erythropoietic system, and pancreas. For women the following localizations are listed: mammary gland, large intestine, stomach, ovaries, uterus, rectum, lung, skin including melanomas and gall bladder.

Aged↗

PubMedDate not supplied

[Intestinal arteriosclerosis. Pathomorphological findings, localization and occurrence].

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Age Factors↗