PubMed Health⌕ Search

Biomedical subjects

K Gonda

Publications and source records attributed to K Gonda.

23 records · Page 2Linked to original sources
PubMed1997

Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2.

Vascular proliferative disorders are characterized by the proliferation of vascular smooth muscle cells (SMCs) and excessive extracellular matrix synthesis. We found that bone morphogenetic protein-2 (BMP-2) inhibited serum-stimulated increases in DNA synthesis and cell number of cultured rat arterial SMCs in a fashion quite different from that in the case of transforming growth factor-beta1 (TGF-beta1). In addition, TGF-beta1 stimulated collagen synthesis in SMCs, whereas BMP-2 did not. In an in vivo rat carotid artery balloon injury model, the adenovirus-mediated transfer of the BMP-2 gene inhibited injury-induced intimal hyperplasia. These results indicate that BMP-2 has the ability to inhibit SMC proliferation without stimulating extracellular matrix synthesis, and suggest the possibility of therapeutic application of BMP-2 for the prevention of vascular proliferative disorders.

Adenoviridae↗
PubMed1982

Adsorption of liposomes by clay.

The interaction between liposomes and clay was investigated. Lecithin liposomes were adsorbed by montmorillonite, and aggregation of the clay particles occurred. From studies using differential scanning calorimetry (DSC), the transition temperature (Tc) from a gel to a liquid-crystalline state of this phospholipid increased by several degrees on adsorption by the clay. Although a lecithin molecule as a whole seems to have no net charge, liposomes were considered to have been adsorbed by the clay via the choline positive charge, which occupies the outermost part of the liposome membrane, as the clay is known to be negatively charged.

Adsorption↗
PubMed1977

Proton conduction in phosphatidylethanolamine.

The dc conductivity of polycrystalline phosphatidylethanolamine (PE) was measured in the temperature range 60-120 degrees C. Since no conclusive evidence had so far been obtained for the presence of proteon conduction in this phospholipid, hydrogen gas was shown in the present experiment to evolve during the electrolysis in its premelted state between 91 and 124 degrees C. In this temperature range molecules assume rotation around the molecular axes and proton conduction of the Grotthus type takes place possibly along two chains of intermolecular hydrogen bonds running in parallel. Zwitter-ions behave cooperatively as proton donors and acceptors in transferring proton from molecule and molecule via the hydrogen bond networks. This efficient push-pull way of proton transferring seems to account for the fact that no polarization was observed in the dc conduction experiments. The amount of devolved gas appears to be not exactly in accordance with Faraday's law and discussions are made on possible causes for this slight deviation.

Electric Conductivity↗