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Biomedical subjects

K Gotfredsen

Publications and source records attributed to K Gotfredsen.

12 recordsLinked to original sources
PubMed1991

A method for histological preparation of undecalcified bone sections containing acrylic bone cement.

An improved and time reducing method is presented for the histological evaluation of bone containing polymethylmethacrylate (PMMA) bone cement. The undecalcified bone was embedded in epoxy resin and section of 50-100 microns thickness were produced using a commercially available cutting grinding system. The sections were stained with Stevenel's blue and van Gieson picrofuchsin or a modified hematoxylineosin. PMMA bone cement was not dissolved and remained enabling examination in situ of an intact cement bone interface and tissue reaction without decalcification.

Animals↗
PubMed1991

Histologic analysis of a retrieved hydroxyapatite-coated femoral prosthesis.

A hydroxyapatite-coated hip hemi-prosthesis was retrieved from a 98-year-old osteoporotic woman 12 weeks after implantation. Histologic analysis revealed bone and fibrous tissue almost evenly distributed around the surface of the implant circumference. Quantitative histologic analysis showed that 48% of the hydroxyapatite surface was covered by bone. Fibrous tissue covered 30% of the prosthetic surface, and 20% of the surface had no tissue coverage. Scanning electron microscopy showed direct contact without any clear boundary between the newly formed bone and the hydroxyapatite ceramic.

Aged↗
PubMed1990

Bone growth into a revised porous-coated patellar implant.

A noncemented and clinically stable porous-coated patellar component (PCA) was removed from a patient after 11 months because of infection. It was sectioned and examined histologically in undecalcified, thin-ground sections. The bone ingrowth into the porous space was measured at eight levels. Each histologic section was quantified by a conventional point-counting method using a square grid. There was inhomogeneous, but extensive, bone ingrowth, often extending to the core of the patellar component, with direct contact between bone and porous coating without any interstitial fibrous membrane.

Adult↗
PubMed1990

ITI implants with overdentures: a prevention of bone loss in edentulous mandibles?

Changes in the bone mineral content (BMC) of edentulous mandibles with osseointegrated ITI implants supporting overdentures were measured in vivo by dual-photon absorptiometry. The BMC measurements were performed 3 weeks postoperatively and at the 2-year follow-up visit. Measurements were made in the ITI site (anteriorly), the premolar region just behind the fixtures, and the standard site of the mandible for obtaining reference values of the age-related MBC loss. The increased function of the mandible after this treatment seems to cause a load-related bone formation that minimizes, or in some cases may counteract, the physiologic age-related BMC loss leading to osteoporosis.

Absorptiometry, Photon↗
PubMed1989

A method for preparing and staining histological sections containing titanium implants for light microscopy.

An improved method for preparing and staining ground tissue-implant sections for light microscopy is presented. Undecalcified tissue blocks with titanium implants were dehydrated in an ascending series of ethanol and stained in toto with basic fuchsin. Specimens were infiltrated and embedded in methyl methacrylate and sections were prepared using a cutting-grinding-system. The polished surface was counterstained with light green or anilin blue. Light polymerizing resin was used as slide mounting medium and for mounting the coverglass. The sections obtained were 10-15 microns thick with tissue architecture which clearly differentiated structures at the tissue-implant interface. The method was very useful for computer assisted morphometric analysis.

Animals↗
PubMed1989

[The reactions of patients to mandibular osseointegrated dental prosthesis/implants].

A removable denture as rehabilitation for complete edentulousness is not always sufficient treatment. Some patients cannot achieve acceptable function with this treatment and psychosocial problems sometimes arise. In recent years an alternative treatment has been available for these patients, viz. treatment with overdentures supported by oral implants. An interview has been made with the first 10 patients. The treatment was 3 to 5 ITI-implants in the mandible between the mental foramina. A barconstruction stabilized the implants and barclips were placed in the denture. There was a very positively reaction to the treatment. The patients have an improvement in oral function and retention of the denture. Also the psychosocial sequelae from which some of them previously suffered were reduced or removed.

Attitude to Health↗
PubMedDate not supplied

Histological and histomorphometrical evaluation of tissue reactions adjacent to endosteal implants in monkeys.

A qualitative and quantitative histological study of the initial healing response adjacent to 24 submerged and non-submerged implants placed in the lower jaws of 6 monkeys is presented. The histomorphometric analysis showed no significant differences in mineralized bone-implant contact length between submerged and non-loaded non-submerged titanium implants. The infrabony defects around some of the implants on the radiographs were significantly correlated to the histological measurements. Qualitatively, a greater number of gingival inflammation cells and a longer junctional epithelium were seen adjacent to non-submerged implants without oral hygiene than were seen adjacent to non-submerged implants with oral hygiene in the initial healing period.

Animals↗
PubMedDate not supplied

Clinical and radiographic evaluation of submerged and nonsubmerged implants in monkeys.

The purpose of this study was to compare the healing response of submerged implants with that of nonsubmerged implants and to determine the influence of oral hygiene procedures on the initial healing response adjacent to nonsubmerged implants. Radiographs demonstrated direct bone-implant contact of submerged and nonsubmerged implants. No significant differences in bone-implant scores were recorded between the submerged and nonsubmerged implants with oral hygiene. Oral hygiene procedures during healing had a positive influence on the gingival status and marginal bone height adjacent to nonsubmerged implants.

Alveolar Process↗