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K Gottlieb

Publications and source records attributed to K Gottlieb.

38 records · Page 3Linked to original sources

Endoscopic lithotripsy of bile duct stones using a new laser with automatic stone recognition.

Biliary stones can be removed in 85% to 90% of patients using endoscopic sphincterotomy; in the rest alternative methods are required. Thirty-eight consecutive patients in whom conventional methods had failed underwent laser lithotripsy with a new laser system. A flashlamp-pumped pulsed laser with rhodamine 6G as dye (594 nm) has a tissue-stone recognition system that can identify bile duct stones by analyzing backscattered light and interrupt the pulse in case of tissue contact (Lithognost, Telemit, Munich, Germany). Access of the 0.25- or 0.30-mm-diameter laser fiber to the stones was achieved perorally in 18 patients. In 13 of these cases, eccentrically located stones in the middle or proximal common bile duct were targeted with a 3.4-mm miniscope introduced through a standard duodenoscope. Fluoroscopically guided peroral lithotripsy was performed in 5 patients with stones in the distal common bile duct that could be approached with a standard ERCP catheter. Percutaneous cholangioscopic laser lithotripsy was carried out in 20 patients with stones not amenable to retrograde techniques. The mean number of bile duct stones per patient was 3.6, and the average diameter of the largest stone of each patient was 25 mm (range, 8 to 52 mm). The bile ducts were cleared in all but 1 patient in a mean number of 1.3 sessions lasting 15 to 115 minutes (mean, 60). No laser-related complications were observed. The Lithognost laser was successfully used in 37 of 38 patients referred for the removal of difficult bile duct stones.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Non-analytic problems in detecting arsenic and cadmium in children living near a cadmium refinery in Denver, Colorado.

The aim of the present study was to determine urinary arsenic (N = 322) and cadmium (N = 366) levels in children aged six months to six years who live near a working cadmium refinery and to compare their values with those of children from comparison neighborhoods. A questionnaire designed to identify exposure pathways was administered to the parents. There were unexpected problems in the study. Eighty-four percent of the arsenic samples were below the detection limit of 10 micrograms/l and summary statistics could not be calculated. Urinary arsenic and cadmium values could not be standardized for volume and concentration of urine because a large proportion of the samples had very low creatinine values. The original round of cadmium testing was afflicted with contamination problems, possibly due to the mishandling of pediatric urine bags by the parents during the collection procedure. A retest for cadmium levels under clinical conditions showed lower cadmium levels, all but two were below the detection limit. While biological monitoring of exposure to metals can be undertaken indirectly by measuring the concentration of the metals in urine, the analyses in this study were complicated by (1) not using more sensitive analytical tests for arsenic and cadmium determination, (2) not being able to standardize children's urinary values with creatinine, and (3) allowing in-home urine collection.

Arsenic↗