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Biomedical subjects

K Gräfenstein

Publications and source records attributed to K Gräfenstein.

17 recordsLinked to original sources
PubMed1990

[Use of computer-assisted Doppler sonography and rheography in acral vascular diagnosis in progressive systemic sclerosis].

For the quantitative characterization of the blood flow of patients with progressive systemic sclerosis a combined computer-assisted Doppler sonographic as well as rheographic measuring place was established. An aimed examination of the peripheral situation of the blood supply was performed in 15 patients with progressive systemic sclerosis in comparison to a control group of patients with healthy vessels. The demonstration of the corresponding parameters of time and form of the curves resulted in significant differences for the two examination groups, particularly of the pulsation index (PI) and the index of the peripheral resistance (PWI) in the Doppler flow curves as well as for the maximum increase (A) and the peak time (GZ) in the rheogrammes. The computer-assisted functional-diagnostic investigation methods in the peripheral vascular region offer themselves for the objectivation and the assessment of the course of the participation of the vessels in the collagenoses.

Blood Flow Velocity↗
PubMed1990

[Difficulty in determining ultrasonic attenuation values from selective echograms].

The value of tomography is beyond all doubt. Custom systems allow the quantitative assessment of topographic and kinetic parameters of various organs and the blood. The assessment of tissue, however, is still qualitative and experimental methods for quantitative tissue characteristics are still expensive. We propose a method, that allows the determination of attenuation coefficients with little technical expense.

Humans↗
PubMed1989

[Thorotrastosis--a rare disease picture in internal medicine].

The report deals with the late effects following administration of thorotrast in a 63-year-old patient: liver cirrhosis developed after application of thorotrast 25 years ago. The clinical findings are described and attention is drawn to the relevance of this disease at present time. The authors refer to the significance of the routine X-ray diagnosis and of the CT for finding a diagnosis with thorotrastosis.

Humans↗
PubMed1989

[Ultrasound-controlled fine-needle puncture with a specially prepared puncture needle].

The described puncture needle with dual amplified point has been successfully applied at the Medical Clinic of the County Hospital Halle for more than half a year now. Better reflecting capacity in both vitro and vivo results from preparation of the needle point's surface. The more clear visibility of the needle point in the ultrasonic sectional view results in a better display during the whole process of puncture and makes possible a better locating also under difficult sonographic conditions. By the application of the described puncture needle the safety of the ultrasonic directed fine-needle puncture increases for both patient and examiner.

Biopsy, Needle↗
PubMed1989

[Studies of protein clearance in detecting early renal involvement of lupus erythematosus].

By means of protein clearance investigations the differentiation of the damage degree of the kidneys is to be described in a certain extent also with lupus nephritis. The in 1982 stated proteinuria elimination of 0.5 g/24 hour as a criterion for a renal participation could be the cause for the often relatively late stated kidney participation in the LE. The determination of selective and nonselective excreted proteins in connection with the detection of the double strain-DNS antibodies might be more proper to indicate a kidney participation.

Albuminuria↗
PubMed1988

[Cardiac involvement in rheumatic diseases].

In the enclosed paper cardial changes of different rheumatic diseases are concerned. It refers to the change concerning the cardial symptoms of the single diseases and differential diagnostic considerations are made. Essential cardial symptoms and important symptoms and therapeutic possibilities are named.

Arthritis, Juvenile↗
PubMed1988

[Basic drug therapy of rheumatoid arthritis].

At first the term of basic therapeutic preparations is explained. Then the essential representatives of the basic medicaments are described, in which cases the author particularly pays attention to their therapeutic mechanisms, the clinical efficiency and their dosage. Out of the number of the possible basic drugs preparations with guaranteed efficacy are particularly described.

Anti-Inflammatory Agents↗
PubMed1987

[Studies of protein clearance in patients treated with and without gold preparations in rheumatoid arthritis].

It is reported on investigations of protein clearance in rheumatics treated with Tauredon in comparison to non-treated patients suffering from rheumatoid arthritis. In that way no significant differences concerning the secretion of selective and unselective proteins could be found between the observed groups of patients. Secondary effects of the gold therapy in the form of a relevant proteinuria as elaborated by some authors cannot be confirmed in our patients. On the other hand investigations of protein clearance allow the premature recognition of renal failure and thus they can contribute to the increasing of the patients' security in the application of this therapy.

Arthritis, Rheumatoid↗
PubMed1985

[Biochemical aspects of the pathogenesis of the late diabetic syndrome].

First of all the three essential patho-biochemical reactions of insulindependent tissues with glucose excess are being outlined especially in order to emphasize the non-enzymatic glycolysation as an essential factor for the development of the diabetic late syndrom. Within the glycolysation reactions of the glucose with albumins it is especially being referred to the connection with haemoglobin, fibrinogen, albumin, kristallin, myelin, the membrane proteins and apoproteins and it is shortly being reported on the clinical effects.

Apoproteins↗
PubMed1985

[Problems and observations on progressive systemic scleroderma].

At first the pathogenesis of sclerodermia is discussed. Disturbed immunological control mechanisms for the activity of fibroblasts with an increased humoral activity are mentioned as causes. Then relevant clinical changes in connection with own investigations are outlined and finally some therapeutic possibilities are mentioned. The pathobiochemical changes of the collagen metabolism of sclerodermia are analysed and own investigations about the laboratory parameters, hydroxyprolin and N-acetyl-neuraminic acid which summarizingly reflect the collagen metabolism in patients with sclerodermia follow. Finally diagnostic possibilities of a renal participation are shown with the help of a quantitative and qualitative protein analysis in the collective urine, in which case a particular point is to be made of the distinction of selectively and unselectively excreted proteins.

Collagen↗
PubMed1985

[Relation between glycohemoglobin, hypoxia parameters and diabetic microangiopathy].

In normal persons and in diabetics with and without tissue injuries was tried to find out a connection between the glycolyzed haemoglobin and the parameters of hypoxia. In a small number of cases no clearly evident correlation between the concentrations of the 2,3-diphosphoglycerate and the lactate to the glycohaemoglobins was found. In connection with this investigation pathobiochemical considerations of late diabetic injuries are carried out, which are the consequence of inconveniences in the usability of glucose of diabetics and the connected with this non-enzymatic glycosylation of various proteins.

2,3-Diphosphoglycerate↗
PubMed1978

[Possibilities of diagnostic standardization in the differential diagnosis of comatose conditions on the basis of the working methods of a grade IIb laboratory].

In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view. It is referred to the significance of a laboratory-diagnostic programme for the differential diagnosis of comatous conditions. In this case the material and personal prerequisites and the laboratory capacity of a district hospital are taken into consideration.

Cardiovascular Diseases↗