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Biomedical subjects

K Grabitz

Publications and source records attributed to K Grabitz.

42 records · Page 3Linked to original sources
PubMed1986

[Primary retroperitoneal tumors].

73 patients, 41 males and 32 females, were treated for primary retroperitoneal tumours between 1974 and 1984. Mean age of the patients was 45.9 years (range: 1 day-79 years). Early symptoms of the tumours were atypical. Initial diagnosis showed a palpable abdominal tumour in 47 patients. Computed tomography is the most important radiologic tool for the diagnosis. In 32 patients the tumour could be removed completely. Intraoperatively, at least one additional organ had to be removed in all patients to ensure radicality of extirpation. Histology showed most tumours to be lymphomas or sarcomas. At the time of diagnosis, 21 patients were found to have metastases. Operative mortality rate was 11%. The overall prognosis in patients with primary retroperitoneal tumours is poor; the 5-year survival rate for malignant tumors was 9%. Combination of radio- and chemotherapy has somewhat improved this dim prognosis in recent years.

Adolescent↗
PubMed1985

[Esophagus resection without thoracotomy in cancer. Report of experiences with 100 cases].

Between 1980 and 1984 126 patients were admitted to the surgical department of the University of Düsseldorf for cancer of the esophagus. 100 (= 79%) patients were operated upon. In the majority of cases we dealt with advanced tumors (76% stage III and IV UICC). In 87 patients the esophagus was removed by transhiatal blunt dissection. In 13 patients the tumor bearing esophagus was bypassed by the substernally transferred stomach. Overall mortality was 20%. Varying with tumor stage the median time of survival was 5,5 months, again with wide variation depending of tumor stage. Only in stage I and II tumors there is a chance of significant prolongation of life or even cure. The majority of our patients and their relatives considered the outcome of the operation as a success, even if the time of survival was only short.

Adult↗
PubMed1984

[Results of stomach pull-through operations without thoracotomy in the treatment of advanced esophageal cancer].

Between 1960 and 1983 we have seen 525 cases of oesophagus carcinoma at the Surgical Dept. of the University of Düsseldorf. Up to 1980 we performed the thoraco-abdominal approach with a resection rate of 30%. After that we performed blind dissection of the oesophagus using the abdominal approach only and the resection rate increased to 75%. This last group of patients was treated preoperatively with 3000 R. In spite of very late cancer stages our operative mortality rate decreased considerably and the 2 year survival rate improved. We believe our method to be a standard one because there is a very bad long-term prognosis of the condition.

Adult↗
PubMed1979

[Scanning electron microscope study of the lung epithelium of the rabbit during ontogenesis].

The development of the bronchial and alveolar epithelium was observed in rabbits from the 15th day post conception until the time of birth with the scanning electron microscope. In the pseudoglandular phase, primitive bronchi proliferate in the mesenchyme. The epithelial cells are not differentiated and have single cilia. After retraction of these single cilia cell differentiation begins. Flat cells densely populated with cytopodia can be recognized on the 22nd day, ciliated cells on the 23rd day post conception. Both are located in the bronchi near the hilus. In the canalicular phase of development, the differentiation of the mucoid cells and the Clara-cells begins. The interstitial connective tissue develops more and more capillaries. The alveolar phase begins around the 26th day p. c. The lung capillaries reach the alveolar epithelial cells and arrange themselves directly beneath the epithelial basement membrane. This "alveolarization" of the lung tissue starts in the centre of the lung lobules and proceeds to the periphery. After the 26th day post conception the alveolar epithelial cells retract their single cilium and at the same time become type I or type II pneumocytes. The undifferentiated entodermal stem cell of the alveolar epithelium is the pneumoblast.

Animals↗