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Biomedical subjects

K Grimmel

Publications and source records attributed to K Grimmel.

At least 19 recordsLinked to original sources
PubMed1979

[Studies on drug metabolism in obese men and mice (author's transl)].

In 7 obese patients with an overweight of 53 +/- 19% of Broca we found a 2-fold enlarged apparent volume of distribution and a nearly 2-fold prolonged elimination halflife of hexobarbital; the hexobarbital plasma clearance however, which is nearly identical with the metabolizing capacity of the liver for hexobarbital, was not decreased. Phenobarbital induced the microsomal drugmetabolizing enzyme system in the fatty liver of genetically obese mice in the same way 2-3-fold as in the non-fatty liver of the lean littermates.

Adolescent↗
PubMed1977

Activities of intestinal enzymes in experimental chronic renal insufficiency.

Rats with chronic uremia following five-sixths nephrectomy showed a significant fall in the sucrase and maltase activities in the small intestinal mucosa, the lactase and cellobiase activities in contrast remained uninfluenced. The activity of the L-leucyl-L-proline and L-methionyl-L-proline dipeptidases in the small intestinal mucosa was significantly increased, while the activities of seven other dipeptidases studied were unaffected. The mucosal protein and DNA content likewise remained unchanged. Occasional slight alterations of the mucosa were the only finding at histology.

Animals↗