Microtubule proteins in the yeast, Saccharomyces cerevisiae.
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Biomedical subjects
Publications and source records attributed to K Gull.
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The effect of a MGL upon fetal activity has been studied in 39 normal and 54 high-risk pregnant patients between 30 and 42 weeks' gestation. The perinatal morbidity and mortality rates were significantly lower in the group showing an increase in fetal activity following a MGL. It is suggested that this may be useful for identifying the fetus at risk.
Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming to 37 degrees C gives rise to a limited amount of microtubule assembly. The possible involvement of griseofulvin-induced aggregation of microtubule protein at 0 degrees C in the inhibition by griseofulvin of microtubule assembly in vitro is discussed.
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