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Biomedical subjects

K H Bauer

Publications and source records attributed to K H Bauer.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Cholecystectomy and colorectal cancer. Does cholecystectomy increase the risk of developing colon cancer?].

PROBLEM: Within the course of the last ten years, a possible association between carcinoma of the colon and prior cholecystectomy has been discussed. METHODOLOGY: In 342 patients with colorectal carcinoma, and in a control group of 182 patients with gastric carcinoma, the rate of prior cholecystectomy was investigated. RESULTS: The cholecystectomy rate in the case of colon carcinoma patients was 7.9, and thus differed non-significantly from that of the control group (5.5%). At least in our case material, no relationship was found between cholecystectomy and carcinoma of the colon. The results reported in other studies are compared and discussed.

Aged↗
PubMed1992

Pharmacodynamic and pharmacokinetic evaluation of a new transdermal delivery system with a time-dependent release of glyceryl trinitrate.

The pharmacokinetics of glyceryl trinitrate (GTN) and its main metabolites as well as the hemodynamic effects of a new transdermal delivery system (TDS) were investigated in ten healthy male volunteers using a single blind, placebo-controlled study design with an application period of active drug of 4 successive days. The adhesive-type matrix system contains 20-mg GTN and released about 75% in a time-dependent manner. The plasma concentrations of GTN and its metabolites 1-2- and 1-3 glyceryl dinitrate reflected the time-dependent release with higher plasma concentrations during the first 12 hours than during the second 12 hours. Continuous administration of the TDS, which released 15 mg GTN/day, caused an accumulation of GTN in the plasma (about 70% greater AUC at the fourth day in comparison with the first day). The total effect per dose on the a/b-ratio of the digital pulse (height of the peak of the systolic wave divided by height of the peak of the dicrotic wave) and the reflex tachycardia were diminished by about 50% and 37%, respectively, at the fourth treatment day. The effect on systolic blood pressure measured under orthostatic conditions was blunted already 8 hours after the first application. The effect of sublingually administered GTN on digital pulse was attenuated during administration and also 1 hour after removal of the last TDS. The effect was restored 8 to 12 hours after removal of the TDS. Thus, the discontinuous release of GTN from the new system does not prevent the decline of hemodynamic efficacy during continuous therapy.

Administration, Cutaneous↗
PubMed1991

[Carcinoembryonic antigen (CEA) in ascites].

The diagnostic value of carcinoembryonic antigen (CEA) was studied prospectively in 18 patients with ascites of malignant and 28 patients with ascites of benign genesis. Both sensitivity and specificity reached 83%. With a prevalence of malignant disease of 38%, the positive and negative predictive values were 75% and 89%, respectively. In contrast to frequent false-positive CEA values in the serum of liver cirrhotics (48.3%), false-positive CEA values in the ascites of the same patients were observed in only 17.3%. It is thus recommended that if CEA determination is to be employed, it should be done in the ascites itself.

Ascites↗
PubMed1991

[Sonographic versus radiological assessment of chronic outer ligament instability of the upper ankle joint].

Chronic instability of the lateral upper ankle joint ligament is usually diagnosed by clinical and radiological examination. For the evaluation of an ultrasound method of testing lateral instability of the ankle joint we carried out a prospective study. We examined 23 adults who were actively engaged in some form of sport (21 male, 2 female, mean age 32 years) and had a preexisting lateral instability of the ankle. The instability was measured in the standard planes using Scheuba's stress apparatus with simultaneous ultrasound monitoring. The ultrasound examination was performed by positioning the 5-MHz applicator on the lateral side of the Achilles tendon, thus defining a plane from which the instability could be measured in both examination planes by observing the deviation between dorsal inferior edge of the tibia and the dorsal border of the talar roll. For the two examination planes, Spearman's rank-correlation coefficient between the radiological and ultrasound methods was 0.83 and 0.92. The sensitivity of the ultrasound method was 0.90, and the specificity was 0.85. Our study showed a good correlation between the two methods. A pathological talar tilt according to radiological criteria was also revealed by ultrasonography. Thus, all the advantages of ultrasound are now available for the evaluation of chronic lateral instability of the ankle joint.

Adult↗
PubMed1991

[Postoperative small intestinal motility after abdominal surgery].

After abdominal surgery there is a postoperative small bowel ileus. We evaluate whether the duration of the small bowel ileus is depending on the kind of surgery or not. Over a needle catheter jejunostomy a 3-tip transducer was placed into the distal jejunum. At the end of the operations a pressure detector was connected to measure the intraluminal pressure continuously over five days. Group A consisted of three patients undergoing explorative laparotomy because of inoperable gastric cardia cancer, and group B of eight patients who underwent gastrectomy. In none of the patients a normal empty stomach motility pattern, determined by the activity of a migrating myoelectric complex (MMC) was detectable. In group A the normal MMC-activity returned after 24 +/- 4.5 h and in group B after 82 +/- 25 h. Therefore the duration of the loss of the interdigestive myoelectric complex appeared to be dependent upon the type of surgery.

Cardia↗
PubMed1990

[Significance of sonography of the breast for surgical treatment of breast cancer].

In a prospective study of 119 patients with breast carcinoma the value of ultrasonography for surgical therapy was compared with the value of clinical results and mammography. The tumor localization (in 96.8%) and the exact preoperative staging following the pTNM-system (tumor size in 85.8%, lymph node involvement in 77.2%) were better predicted by ultrasonography than by mammography and clinical examination. Especially the multicentric-multifocal carcinomas (20 of 29 cases) were better detected. Preoperative ultrasonography especially improves planning a conservative management of breast cancer.

Breast Neoplasms↗
PubMed1990

[Perioperative ultrasound examination of the breast in breast cancer].

127 cases of breast carcinoma were examined in a prospective study. By means of preoperative ultrasonography the staging following the pTNM-system validates the tumor size in 85.5% and the lymph node involvement in 77.2%. Multicentric-multifocal carcinomas were diagnosed by ultrasonography in 20 of 29 cases, merely 9 of 29 by mammography. Ultrasonography of specimen is recommended in cases of negative clinical findings and positive ultrasound examination to verify tumour excision. In addition to clinical exploration and mammography the ultrasonography of the breast obtains a diagnostic significance for planning a conservative management of breast cancer.

Breast Neoplasms↗
PubMed1989

[Dermatomyositis as a paraneoplastic syndrome. A case report].

A female patient with dermatomyositis with the typical clinical findings of this disease, corresponding histological muscular changes and neurological findings is described. Since in the further course of the disease, recurrent gastric carcinoma was diagnosed, this case again emphasizes the significance of dermatomyositis as a paraneoplastic syndrome, and the need for tumor screening when dermatomyositis is diagnosed in advanced adulthood.

Aged↗
PubMed1989

[The prognostic relevance of tumor localization in colorectal cancer. A multivariate analysis].

Records of 292 patients with colorectal cancer, operated at St.-Josef-Hospital between 1973 and 1984 were studied using Cox regression model to elucidate the prognostic influence of tumor site. Neither in univariate nor in multivariate analysis any significant independent influence of tumor site on prognosis could be detected. Male sex, older age and more advanced tumor stage were independently associated with poorer prognosis.

Aged↗
PubMed1985

A new slow-release form of 5-aminosalicylic acid for the oral treatment of inflammatory bowel disease. Biopharmaceutic and clinical pharmacokinetic characteristics.

A new enteric coated form of 5-aminosalicylic acid (5-AS, Salofalk) for the treatment of inflammatory bowel disease was developed. In 11 hospitalized patients with Crohn's disease or ulcerative colitis the steady-state pharmacokinetics of 5-AS and its major metabolite, N-acetyl-5-AS (Ac-5-AS), was investigated. During treatment with 0.5 g 5-AS tid elimination half-life (t 1/2) ranged from 0.7 to 2.4 h (1.4 +/- 0.6 h, mean +/- SD; n = 6) and mean steady-state plasma levels (Css) of 5-AS and Ac-5-AS averaged 0.7 +/- 0.4 micrograms/ml and 1.2 +/- 0.3 micrograms/ml, respectively. Treatment with the smaller dose of 0.25 g 5-AS tid (n = 5) resulted in a shorter t 1/2 (0.6 +/- 0.2 h), lower Css for 5-AS (0.4 +/- 0.2 micrograms/ml) and Ac-5-AS (1.0 +/- 0.2 micrograms/ml). Urinary and fecal recovery of total 5-AS was calculated to 44 +/- 21% and 35 +/- 10%, respectively. Both compounds were slightly bound to plasma proteins (5-AS: 43%, Ac-5-AS: 78%). In conclusion, the present data would suggest that the new oral dosage form delivers sufficient amounts of therapeutically active 5-AS for local and systemic action in patients with inflammatory bowel disease.

Adult↗
PubMed1981

[Diagnosis of thymoma and CAT assisted transthoracic biopsy (author's transl)].

Thymomas have an uncharacteristic symptomatology. Their spectrum is greatly enlarged by facultative parathymic syndromes. Despite repeated radiographic investigations thymomas can only be diagnosed with certainty by histological investigation of biopsy material. Method, indications and contraindications of transthoracic biopsy of the anterior mediastinum are demonstrated in 3 cases. This relatively simple method permits diagnosis even in inoperable patients, in whom mediastinoscopy and probatory thoracotomy are contraindicated.

Adult↗
PubMed1975

[Introcution to the Topic "The Problem of Cancer" (author's transl)].

How will things progress with cancer? Main facts: cancer increase until 1964. Reversal of sexual proportion (now greater mortality of men). Cancer of different organs changing their relative frequency. In 80% cancer acquired. Enviromental carcinogenes. Percental increase of cancer without carcinogenes by decreasing causes of death (infectious diseases). Future problem: Experimental cancer prevention (tests upon germinal cells for mutagenicity). Since 1964 the level of cancer mortality has remained constant. Decrease is in sight: an anti-cancer future has begun.

Aged↗