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Biomedical subjects

K H Chemnitius

Publications and source records attributed to K H Chemnitius.

At least 37 records · Page 2Linked to original sources
PubMed1975

[Radioimmunologic studies on serum gonadotropic hormones during oral contraception].

In 10 women serum FSH- and LH-concentrations (radioimmunoassay) were measured daily throughout a complete cycle. 2 patients exhibited untreated biphasic menstrual cycles. 2 women were under the treatment of a combined estrogen - progestagen preparation, 1 woman was taking a sequential preparation, and 5 patients were treated with a weekly dose of a recently developed depot - estrogen (ethinylestradiolsulfonate). While the untreated women showed typical serum FSH-and LH-patterns characteristic of the biphasic menstrual cycle, patients on combined therapy were found to have a continuous low FSH- and LH-level except in the postmenstrual phase of the cycle, in which the values were slightly elevated. Serum-FSH-concentration in the woman on the sequential preparation remained constant throughout the treatment peroid, while serum LH-pattern showed multiple peaks. In the same manner, serum LH-patterns in women on the weekly depot- estrogen regimen were characterized by nearly regularly appearing LH-peaks, which seemed to be correlated with the estrogen intake. The cause and clinical significance of these findings are discussed.

Contraceptives, Oral↗
PubMed1974

[Effect of long-term application of SUISYNCHRON-premix on swine].

Two groups of five female store pigs, weighing an average of 60 kg at the start of the experiment, were given either 1 or 10 mg metallibure zinc complex (SUISYNCHRON) per kg body weight once daily for six months, in the form of a 2% talcum premix added to concentrates. Clinical inspection, weight gain, haematological findings, blood sugar, serum transaminases, properties of urine and faeces, carcass examination and histological study (internal organs, endocrine glands, skeletal muscle) showed that the 1 mg/kg dosage had no toxic effect. The 10 mg/kg dosage resulted in considerable depression in appetite and some apathy in the pigs, but there was no evidence of a toxic effect.

Alanine Transaminase↗
PubMed1974

[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 4. Analysis of residuals in pig carcasses].

Twelve groups of German Edelschwein were given the recommended dosage of metallibure zinc complex (SUISYNCHRON) or 5 and 10 times this dosage. Residues were determined in liver, muscle and fat of pigs killed 3-5 hours or 1,2,4,7 or 10 days after the end of administration. In agreement with report in the literature, the highest content was found in liver, followed by meat, with hardly any residues in fat. Taking into account the accuracy of the method of determination, significant residues were present in the liver of pigs given ten times the normal dosage and killed after 3-5 hours of 1 and 2 days, but in muscle only in those killed after 3-5 hours; the content in fat did not differ significantly from that of the untreated controls.

Adipose Tissue↗
PubMed1974

[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 1. Effect on gonadotropic function of the rat hypophysis].

The antigonadotrophic activity of the metallibure preparation TURISYNCHRON and its zinc complex SUISYNCHRON was investigated in rats by measuring inhibition of testicular growth, inhibition of ovulation and effect on the oestrous cycle. The zinc complex was less active in the ovulation inhibition test, in contrast to the testicular inhibition test, and this was attributed to its peculiar mode of absorption.

Animals↗
PubMed1974

[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHROM. 2. Toxicologic findings].

Acute, subacute and chronic toxicity of TURISYNCHRON and its zinc complex (SUISYNCHRON) was tested in mice, rats and dogs. The acute toxicity of SUISYNCHRON was lower than that of TURISYNCHRON in mice and rats. Ulcerative lesions in the duodenum produced by high doses of SUISYNCHRON were quantitatively less pronounced than those produced by similar doses of TURISYNCHRON. Subacute toxicity testing in rats showed that neither preparation had any toxic effect on haematological, clinical chemical or histological criteria in the dosages selected. Chronic toxicity testing of TURISYNCHRON in dogs did not reveal any evidence of toxic damage.

Acute Disease↗
PubMed1974

[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 3. Selected pharmacologic and immunologic findings].

Comparison of the action of TURISYNCHRON and its zinc complex SUISYNCHRON in mice, rats and dogs showed that neither compound interfered with the implantation process in rats. After oral administration, blood concentrations were lower with SUISYNCHRON than with TURISYNCHRON. The zinc complex was broken down in the acid medium of the stomach, and absorbed in the duodinum or in distal segments of the intestine. Metallibure did not affect on phagocytosis not the course of infections with Escherichia coli or Erysipelothrix insidosa. Both compounds had a thymolytic action, which did not mimic the effect of cofticosteriods.

Adrenal Cortex Hormones↗