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Biomedical subjects

K H Gabriel

Publications and source records attributed to K H Gabriel.

4 recordsLinked to original sources
PubMed2000

[ESES-syndrome in child- and adolescent psychiatry].

OBJECTIVES: The article describes the theoretical background of the diagnosis and therapy of the ESES syndrome. METHODS: The assessment and treatment of children with ESES in a child-psychiatric setting is shown. The underlying data have been taken from 18 outpatients with or without epileptic seizures. RESULTS: The early diagnosis of non-specific symptoms and the anti-epileptic treatment probably play an important role in preventing the progression of ultrastructural brain damage. Sultiam is the drug of first preference.

Anti-Anxiety Agents↗
PubMed1977

[Problems in serum-level determination during valproic acid therapy].

An investigation was carried out to determine whether or not a reliable and reproducible steady state serum level of the anticonvulsant drug valproic acid could be found, such that single values of a serum level determination could be used in therapeutic control. 1. A reliable and comparable serum concentration of valproic acid could not be found in 11 patients during a long-term investigation over a period of 8 weeks. Likewise this could not be found in the 24-h serum concentration profile in 8 of the above mentioned patients, who were receiving both mono and combined therapy. 2. The half-life values for valproic acid in these 8 patients lay between 8--12.5 h. 3. The maximum concentration of valproic acid lies in unforeseeable time spans after drug administration. 4. The morning fasting values are comparable only to a limited extent. In future daily profiles it must be decided whether, and if so to what extent, valproic acid serum concentration determinations can be of value to the individual treatment of epileptics.

Adolescent↗