Biomedical subjects
Publications and source records attributed to K H Gramowski.
In a summary representation the therapeutic principles are shown applying radiotherapy in epithelial tumors of epi-, meso-, and hypopharynx on base of actual references in literature and own results. Especially by combination therapy a trend indicates improvement of therapeutic results.
The retrospective analysis of a radiotherapeutical material includes 452 patients with laryngeal carcinoma of the University Jena during the period from 1964 to 1981. The primary radiotherapy was done according to therapeutic protocol exclusively in glottal tumors of stage T1 and T2, exceptionally refusers of operation or inoperables. The portion of total laryngectomy is accordingly high with 47.6% of all patients. The 5-years-survival of all patients is 48% (217 of 452 patients). The results are compared with results of other therapeutic statements.
The nasal flow rate is a sensitive parameter for recording respiration reactions evoked by smelling. A method is presented for objectifying measurement of different severe hyposmias. Using the monorhine respiration-olfactometry, one side of the nose is stimulated olfactorily, in the other one the nasal flow rate is registered simultaneously. 22 patients suffering from light and severe hyposmia could be exactly classified corresponding to the severity of hyposmia. There were no smell-induced respiration reactions below the detection threshold. The reaction thresholds of respiration-olfactometry correspond to the detection thresholds of subjective olfactometry in 94% of the patients.
Multi-step check method of the diagnosis of malignancy is applied as a synthesis of results of staging, histological classification, histopathological and histochemical grading, to 210 squamous cell carcinomas of the mesopharynx. Among the examined carcinomas, extended tumours were predominant (61%) (T3; T4). No definite relationship between size and prognosis of the tumours was seen. 81% of the carcinomas had regional lymph node metastases. Their rate of cure (41%) was lower than that of the carcinomas without metastases. Histological grading showed that prognosis of the G 1-carcinomas was superior to that of the G 3-carcinomas. Definite histological grading also enabled clear gradation of malignancy of G 2-carcinomas and carcinomas of the lymphatic tissue after histochemical grading. 5-year survival rate of all the therapy results were found after radical resection (50%) and after combined surgical irradiation therapy (63%). The survival rate of the patients with exclusive irradiation therapy was lower (29%).
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At examination of normal persons, the ENG registration method was compared with that of PENG. Special examinations were executed with regard to the behaviour of the beat rates during the culmination phase of thermal labyrinth reactions by using each of both registering methods. By synchronous recording of PENG and ENG, it was possible to settle the discrepancy of the greater number of beats in ENG compared with those of PENG, while the examinations were executed at different times. The PENG-method does not exclude an optical fixation due to the necessary interior illumination, and this results in a retarding of the reaction and smaller beat rates. This fact should be considered when comparing the results of ENG and PENG.
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