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Biomedical subjects

K H Kurz

Publications and source records attributed to K H Kurz.

10 recordsLinked to original sources
PubMed1993

Effectiveness, safety, and acceptability of a copper intrauterine device (CU Safe 300) in type I diabetic women.

OBJECTIVE: To evaluate the long-term effectiveness and safety of a copper intrauterine device fulfilling modern standards in type I diabetic women compared with nondiabetic women. RESEARCH DESIGN AND METHODS: Type I diabetic women (n = 59, age 27 +/- 5 yr, duration of diabetes 12 +/- 8 yr, HbA1c 7.0 +/- 1.2%, 78% nulliparous women) were prospectively evaluated at 3, 6, 12, 24, and 36 mo by a gynecological exam and a standardized questionnaire after insertion of the intrauterine device (CU Safe 300, 300 mm2 of copper). A group of nondiabetic women (n = 1150) of comparable age and parity evaluated according to the same study protocol served as a control group. RESULTS: In the diabetic women (1754 cumulative months of use), events leading to termination of the intrauterine device during the 1st yr (691 women-mo) were one accidental pregnancy, one expulsion, one removal for pain, two removals for bleeding, and one removal for planned pregnancy. Events during the 2nd (593 women-mo) and 3rd yr (470 women-mo) were zero and one accidental pregnancy., one and two removals for bleeding, one and one removal for pain, one and one removal for other medical reasons, and two and two removals for planned pregnancy, respectively. No case of pelvic inflammatory disease was diagnosed in the diabetic group, and one case was diagnosed in the nondiabetic group (28,369 mo of cumulative use). Events leading to termination of the intrauterine device per women observed per year and continuation with the intrauterine device after each year of use were comparable in the diabetic and nondiabetic groups for the 1st, 2nd, and 3rd yr. CONCLUSIONS: These results, although preliminary because < 100 diabetic women were studied, indicate that the intrauterine device CU Safe 300 is as effective, safe, and well-tolerated in diabetic as in nondiabetic women. Specific objections to the use of intrauterine devices in type I diabetic women do not seem to be justified for modern, copper-mediated models.

Adolescent↗
PubMed1988

[Keratosis palmoplantaris diffuse circumscripta (Thost-Unna) with micropenis].

We report on a 2-year-old boy showing diffuse palmoplantar keratoderma (Thost-Unna's disease) in association with congenital penis hypoplasia. Family history research proved palmoplantar keratoderma autosomally dominant over 5 generations. The boy's 6-month-old brother also shows penis hypoplasia, as yet, however, without signs of palmoplantar keratoderma. So far we are not able to settle the question whether this case represents a clinical entity of its own or merely a chance association of rare symptoms.

Child, Preschool↗
PubMed1984

In vivo measurements of uterine cavities in 795 women of fertile age.

The uterine sound length, the functional length of the cervix including the zone of internal cervical os and the fundus transversal were determined in 795 fertile women in vivo using a measuring device, the Cavimeter. The functional cavity length was calculated by subtracting the functional length of the cervix from the uterine sound length. With growing parity, the uterine length and width increase, but with advance in age, the uterine cavity changes are not so distinct. The wide ranges found by the investigation demonstrate the individuality of the uterine cavity and the desire to measure it prior to fitting an IUD. The use of adapted IUDs according to the size of the uterine cavity leads to a remarkable reduction of side effects, particularly expulsion, bleeding and cramps caused mainly by dimensional incompatibility. Therefore prefit uterine cavity measurement can lead to better efficacy of IUDs, increased rates of acceptance and higher continuation rates.

Adolescent↗
PubMed1983

Jet injection--local anesthesia for fitting and removal of IUDs.

Women with small uterine cavities and narrow cervical canals in particular suffer from symptoms such as discomfort, pain, cramps, bradycardia, syncope, and epileptoid convulsions during IUD insertions. These problems can be avoided by paracervical block (PCB) with syringe and needle, which may, in rare cases, entail hazardous side effects. These can be eliminated by the use of Jet Injection PCB. The Jet Injector deposits a 2% or 3% anesthetic solution paracervically submucously under high carbon dioxide pressure. The patient's fear of injection with a needle is avoided. The method can be applied by paramedics since intravascular application of anesthetic solution is impossible. The use of a more concentrated anesthetic solution allows dose reduction and the method of dispersion of the micro-drops ensures a more rapid onset. Premedication is not required and disposable material is economized on. This study is based on the application of Jet Injection PCB before insertion of medicated IUDs in 447 women; 60% nulligravidae, 14% nulliparous with abortion(s), 13% primiparae, and 13% multiparous. Age ranged from 15-47 years.

Age Distribution↗
PubMed1982

Role of retention in avoiding expulsion of IUDs--measuring devices for basic research.

320 medicated IUDs were removed from 292 women by means of the dynamometer. This instrument indicates the highest retention force (HRF) in newtons (N). Ages of the women ranged from 17-50 years. The IUDs were fitted in nulligravidae (56%), nulliparous with 1 or more abortions (13%), primiparous (18%), and multiparous (13%) women. The IUDs used were the ML Cu 250-standard, 7 Cu 200, T Cu 200-adapted, with a shortened transversal arm of 15-30 mm and T Cu 200 standard. With the low expulsion rate, the ML Cu 250-standard IUD needed 5.8-5.4N and the 7 Cu 200 3.8-2.6N. The adapted T Cu 200 IUD needed 2.6-1.6N, i.e., about 1N more thant the T Cu 200-standard with an HRF of 1.7-1.0N. As the dynamomoeter only indicated the highest retention force, a retentiograph was devised to demonstrate the different retention forces and phases of the various IUDs by characteristic curves. The possible connections between retention and expulsion of IUDs are discussed. The retention forces of the different IUDs compared are congruent with the published expulsion rates. The retentiograph showed new patterns to test IUDs before they demonstrate side effects in vitro.

Age Factors↗
PubMedDate not supplied

The CU SAFE 300 IUD, a new concept in intrauterine contraception: first-year results of a large study with follow-up of 1017 acceptors.

After more than a decade of basic research with the help of cavimetry, retentiometry, X-ray and ultrasonography, a new intrauterine contraceptive device, the CU SAFE IUD, was developed. The plastic body of the device shows the following properties: uterine cavity compatible, enhanced flexibility, low surface area, fundus-seeking anti-expulsive design, no anchoring mechanisms, and one monofilament without a knot embedded into the shaft. The copper surface area of 300 mm2 guarantees a high efficacy for up to five years. The CU SAFE 300 IUD fulfils all requirements of the International Organization for Standardization (ISO) in regard to intrauterine devices. This paper reports on the first-year results of a large ongoing CU SAFE 300 study, number of insertions 1150. 1017 acceptors of all fertile age groups accumulated 10,576 woman-months of use. The event rates were as following: pregnancy 0.6; expulsion 0.6; removal for bleeding 4.2, for pain 1.5; infection 0.0; other medical 0.9; non-medical 3.1. The continuation rate was 89.1 at the end of the first year. The increased safety and high efficacy of the CU SAFE 300 provides comfort for both user and partner. The ease of insertion without a plunger and gloves (inserter tube diameter 3 mm) and the ease of removal (force of traction approximately 1 N) mean safety also for the medical and paramedical fitter of the CU SAFE 300 IUD.

Female↗