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K H Marquart

Publications and source records attributed to K H Marquart.

At least 19 recordsLinked to original sources
PubMed1994

[Female prostitution and HIV/AIDS--review of the literature on epidemiology and personal observations in a contact center for drug dependent patients].

Epidemiological studies show that intravenous drug use represents the main risk for HIV/AIDS infection among female prostitutes in Germany. According to current information, HIV/AIDS infections are not more prevalent among prostitutes who are not intravenous drug users than in the general population. To establish effective preventive measures against HIV/AIDS infection, we must differentiate between two specific target groups: 1) female intravenous drug users who engage in prostitution to finance their drug addiction, and 2) female prostitutes who are not intravenous drug users. Instead of mandatory health checks by government agencies, registered female prostitutes who rarely use intravenous drugs should be offered health counseling and care. Easily accessible offers in contact centers for intravenous drug users will help HIV/AIDS prophylactic programs to reach women who engage in illegal prostitution to finance their drug addiction. Secondary HIV/AIDS preventive measures at these centers include exchange of syringes and needles, distribution of condoms, initial contact with a drug counselor, treatment of acute medical problems, physician counseling services, and facilities for HIV testing. In addition to this, substitutive therapeutic regimens as alternatives to withdrawal therapy of drug addiction would contribute effectively to HIV/AIDS prevention, particularly for intravenous drug using female prostitutes who are HIV-infected and have discontinued withdrawal therapy.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[A high fraction of drug-dependent patients among anonymously detected HIV-infected patients in Stuttgart].

A high percentage of intravenous drug addicts was found among HIV-infected individuals who had been detected by anonymous testing from May, 1985, to October, 1988, at the AIDS Counselling Service of the Municipal Health Department in Stuttgart. Among the subjects being seropositive for HIV-1 antibodies, 36.6% were drug abusers, while until October, 1988, only 10.3% of the reported AIDS cases in the Federal Republic of Germany were members of this risk group. On the other hand, only 1.9% of 1.001 individuals who came to the AIDS Counselling Service of the Municipal Health Department in Stuttgart for HIV antibody testing were drug addicts. Our observations show that special information campaigns for young people about the risk of HIV infection by intravenous drug abuse should be intensified.

AIDS Serodiagnosis↗
PubMed1989

Retroviral particles in radionuclide-induced murine osteosarcomas: mouse strain-related differences.

Twenty-six osteosarcomas from strain NMRI mice and twenty-six osteosarcomas from (C3H x 101)F1 hybrid mice were investigated by electron microscopy for the presence of retroviral particles. The bone tumors had been induced by the incorporation of the short-lived bone-seeking radionuclides 224Ra, 223Ra, or 227Th. All of the 26 osteosarcomas from NMRI mice contained retrovirus-like intracisternal type A particles in varying quantities. No type C retrovirus particles could be detected. In contrast, most of the 26 osteosarcomas from (C3H x 101)F1 mice contained budding, immature, and mature type C virus particles predominantly in large quantities. Intracisternal type A particles were also present in all tumors from these mice, but were found only occasionally after extensive search. The mouse strain-related differences in the presence of intracisternal type A particles and type C virus particles in the bone tumors do not provide evidence of an etiological relation of these particles to radionuclide-induced osteosarcomagenesis. Some of the mature type C virus particles observed in osteosarcoma tissue from the hybrid mice were atypical in structure and size. Such pleomorphic particles are probably associated with the spontaneous osteomagenesis which occurs in untreated old (C3H x 101)F1 mice.

Animals↗
PubMed1987

[Kaposi disease in an LAV/HTLV-III antibody negative patient at risk for AIDS].

We report on a disseminated variant of Kaposi's sarcoma (M.K.) with a moderate course in a homosexual patient negative for LAV/HTLV-III antibodies. The disease had started at the age of 44 years. Clinical examination proved the patient's good condition. Serological findings revealed numerous former infections. Control investigations for 5 years have not shown any signs of immune deficiency, so far. Morphological investigation (applicable to all forms of M.K.) indicated a reversed differentiation of the vascular connective tissue with ensuing misdifferentiation. Thus, the tumor should be interpreted as an abnormal product of the primary vascular mesenchyme. It is characterized by a synchymal/spongiochymal structure. This view corresponds with older ideas. Recent histochemical and electron microscopical findings do not contradict this conception in any way, but do rather confirm it.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[HIV-antibodies in cord blood samples from Uganda].

Cord blood samples were collected from 140 Ugandan neonates after vaginal delivery from healthy women and were tested for the presence of HIV antibodies. Two ELISA tests were used: "HTLV-III EIA" and "ELAVIA". Eleven (7.9%) of the 140 samples were positive and 127 were negative by both ELISA tests. The positivity of 11 samples was confirmed by immunofluorescence assay and Western blot analysis. Two cord blood samples were negative by the "HTLV-III EIA" test but positive by the "ELAVIA" test. These 2 samples were negative by immunofluorescence assay and positive by Western blot analysis. But only antibodies against the proteins p24, p52, and p65 were revealed. Both samples were negative by radioimmunoprecipitation assay for LAV-I and LAV-II antibodies.

Antibodies, Viral↗
PubMed1985

Slim disease (AIDS)

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Acquired Immunodeficiency Syndrome↗
PubMed1984

Oncogenic retrovirus from spontaneous murine osteomas. I. Isolation and biological characterization.

Spontaneous osteomas in strain 101 mice, a strain which has a high incidence of benign bone tumours, harbour numerous C-type virus-like particles with pleomorphic characteristics. A cell-free extract from osteomas from two mice induced bone tumours, together with osteopetrosis and lymphomas, in newborn mice of the low incidence NMRI strain after a latent period of 12 to 15 months. When C3H embryo fibroblasts were infected with the osteoma extract, the resulting cell line produced virus (OA MuLVC) with a high titre. OA MuLVC was cloned by serial endpoint dilution and NIH 3T3 cells were productively infected. The resulting virus was named OA MuLVN. OA MuLVC and OA MuLVN also induced bone tumours, osteopetrosis and lymphomas 12 to 15 months after injection into newborn NMRI mice. The isolated virus showed typical characteristics of the murine retrovirus group. Fv-1 host range restriction assays classified the viruses as N-ecotropic and XC-positive. Tryptic p30 peptide analysis and RNase T1 fingerprint analysis of OA MuLVC and OA MuLVN indicated that OA MuLVC contains an Akv-like virus as well as additional components, whereas OA MuLVN is closely related to Akv, but not identical to it. Serological analysis of the envelope proteins using monoclonal antibodies also showed the virus to be similar, but not identical, to Akv virus.

Animals↗