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Biomedical subjects

K H Merkel

Publications and source records attributed to K H Merkel.

26 records · Page 2Linked to original sources
PubMed1981

Herpes simplex encephalitis. A modified indirect immunoperoxidase technique for rapid diagnosis in paraffin-embedded tissue.

A modification of a reliable and simple method of the indirect immunoperoxidase technique was used to identify herpesvirus antigen in paraffin-embedded tissue of patients with herpes simplex encephalitis (HSE), as well as in rats and mice. So far we have studied five cases in humans and six in mice and rats. With preincubation, we increased antigenicity and accomplished high specificity. Brown reaction product was found mainly at the periphery of the areas of necrotizing encephalitis. Here it was present in different types of glial cells, as well as in neurons. In the animals, it was found in the leptomeninx in cells of the basal cortex and in the ependymal cells of the third ventricle and the cells around it. This method should be of great value for the study of human pathology because new drugs are available for treatment of HSE and a tissue diagnosis is necessary. It is also a useful technique for studying viral CNS infections in experimental animals.

Animals↗
PubMed1981

[Multiple systemic neuromas of the skin and mucous membranes].

A 58-year-old man is described with fibrillar neuroma of the lips, tongue, mucous membranes of the mouth, and larynx. Also tumors of the capillitium, the neck the trunk, and the arms were found. There were no clinical or blood chemical signs of pheochromocytoma, medullary carcinoma of the thyroid or medullated corneal nerve fibers. It is considered that there is no association with the multiple endocrine adenomatosis type IIb, or with the neurofibromatosis von Recklinghausen.

Humans↗
PubMed1980

[Pathology of intracranial tumors].

Important clinicopathologic problems of intracranial tumors are discussed. Special emphasis is given to the problem of herniation due to increased intracranial pressure. The more important neuroepithelial tumors are demonstrated in regard to the new WHO-classification and biologic and therapy related effects are discussed. Briefly mentioned are also meningeomas, neurinomas and metastases.

Astrocytoma↗
PubMed1980

The surface of human menisci and its aging alterations during age. A combined scanning and transmission electron microscopic examination (SEM, TEM).

Eight macroscopically normal menisci of different ages were obtained at autopsy to study their surface structure. The investigation was carried out using transmission and scanning electron microscopic (TEM, SEM) examinations. The combined methods have not been used before. An understanding of physiologic alterations during age has to be furnished for further research of pathological alterations. The surface relief shows clear differences in different age groups. The meniscus surface of the newborn is built of randomly arranged, equally sized folds and cell formations. The TEM-examination reveals a loose net work of collagen fibrils which is not covered by a membrane-like structure on the joint cavity surface. With age the linear folds become wider extending from the anterior to the posterior segment. They are most prominent in the inner zone; in the middle and outer zone they are flattened at areas of interdigitation. These folds are most likely preparation artefacts rather than closely packed fiber bundles or pathologic osteoarthritic alteration of the surface. This is supported by the TEM examination showing a loose 3-dimensional fiber net work. Early degenerative alterations of the meniscus surface are characterized by a slit-like destruction of this superficial fiber net.

Adolescent↗
PubMedDate not supplied

Cerebrovascular disease in sickle cell anemia: a clinical, pathological and radiological correlation.

An opportunity to study cerebrovascular changes in sickle cell anemia (SCA) presented itself when a black child with this disorder died of bihemispheric strokes. Angiography demonstrated severe occlusive vascular disease involving primarily the circle of Willis and major bifurcations of both internal carotid arteries. Collateral circulation to the distal branches of the internal carotid arteries occurred through transdural anastomoses from the external carotid system and via the leptomeningeal route. Perfusion of the basal ganglia was accomplished by vessels arising from the proximal internal carotid arteries. These changes resembled those of Moyamoya disease. Autopsy showed old and recent cerebral infarcts. Two vascular processes were responsible for the arterial occlusions: (1) exuberant intimal hyperplasia, and (2) old and recent thrombi with partial recanalization. The former has been described only once before in SCA. Small vessels in the basal ganglia were exceptionally numerous and dilated. We conclude that intimal hyperplasia within large cerebral arteries may be responsible for infarction and small vessel prliferation in basal ganglia in patients with SCA.

Anemia, Sickle Cell↗