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Biomedical subjects

K H Neldner

Publications and source records attributed to K H Neldner.

At least 55 records · Page 3Linked to original sources
PubMed1977

Zinc correction of defective chemotaxis in acrodermatitis enteropathica.

Three patients with acrodermatitis enteropathica (AE), a disorder of zinc metabolism, demonstrated a zinc-responsive defect in chemotaxis of neutrophils and monocytes. Monocyte chemotaxis was depressed during a controlled period of zinc deficiency and increased to normal values after administration of oral zinc sulfate supplements that was sufficient to restore normal plasma zinc levels. In the only patient in whom neutrophils were also studied, a similar defect in chemotaxis of neutrophils was corrected by administration of zinc sulfate supplements. Preincubation of defective cells in vitro with zinc sulfate increased chemotaxis in an almost linear dose-response relationship. These findings suggest an important role for zinc in neutrophil and monocyte chemotaxis and demonstrate a correctable immune defect in AE.

Acrodermatitis↗
PubMed1975

Zinc therapy of acrodermatitis enteropathica.

The therapeutic effect of orally administered zinc was evaluated in an adult woman with acrodermatitis enteropathica. When she was off therapy and in clinical relapse the plasma zinc concentration (10 mug per 100 ml), serum alkaline phosphatase (3 1U per liter) and urine zinc excretion rate (39 mug per 24 hours) were extremely low. Di-iodohydroxyquin therapy was accompanied by a modest increase in plasma zinc concentrations. Oral zinc sulfate (220 mg three times a day or 50 mg twice a day) resulted in rapid and complete clinical remission, and in a return of plasma zinc, serum alkaline phosphatase and urinary zinc excretion to normal. These data are compatible with a severe zinc deficiency state and indicate that the inherited defect in this disease is either in or closely related to zinc metabolism. The beneficial effects of zinc therapy in this patient provide further confirmation of the efficacy of oral zinc in the treatment of acrodermatitis enteropathica.

Acrodermatitis↗
PubMed1975

In vitro uptake of calcium by dermis of patients with pseudoxanthoma elasticum.

The calcification of dermal elastic fibers is a characteristic feature of affected skin from patients with pseudoxanthoma elasticum (PXE). Punch biopsies of normal skin and of affected and unaffected skin from patients with PXE were obtained to study dermal calcification in vitro. Before incubation, the calcium, magnesium, and phosphorus content of normal and PXE unaffected dermis were similar and that of PXE affected dermis was significantly higher. Dermal samples were incubated for 2 and 4 days at 37 degrees C. in a calcium phosphate buffer and the Ca and P content were measured. After 4 days of incubation, both PXE affected and unaffected dermis took up significantly more Ca and PO4 than normal dermis. Thus in vitro uptake study could clearly distinguish between normal and PXE dermis. PXE is a disease of variable expression and mild or subclinical forms are difficult to diagnose. Dermal biopsies from clinicallu normal relatives of patients with PXE were obtained and the in vitro uptake of Ca and PO4 was measured. The results show that several of these individuals had elevated uptakes of Ca and PO4 similar to the unaffected dermis of the PXE patient. The results suggest that this test may be used as a diagnostic aid in the detection of individuals with mild forms of PXE and may be a genetic marker for PXE.

Calcinosis↗
PubMed1975

A micromethod for the quantitative analysis of calcium, magnesium, and phosphorus in human skin.

An inexpensive and simple micromethod is described for determining calcium, magnesium, and phosphorus in a 4 mm. punch biopsy of human skin. This small biopsy requires no sutures, and can be repeated frequently with minimal trauma to patients in long-term studies. Normal ranges of calcium (125 to 300 mg. per kilogram of dry defatted weight (DDW), phosphates (450 to 980 mg. per kilogram of DDW), and magnesium (75 to 112 mg. per kilogram of DDW) are similar to reported results on much larger biopsies. Skin calcium but not skin magnesium or phosphate was significantly higher in 40- to 76-year-old subjects when compared to the 20- to 39-year-old individuals. Comparison of an acid extraction method with the standard ashing procedure showed no significant differences in calcium and magnesium content, but the acid extractable phosphate was significantly lower than the total phosphorus found in the ash.

Adult↗
PubMed1968

Ceruminoma.

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Adenoma, Sweat Gland↗
PubMedDate not supplied

How to submit a specimen for cutaneous pathology analysis. Using the '5 D's' to get the most from biopsies.

Evaluation of cutaneous biopsy specimens is greatly assisted by appropriate clinical information from the submitting physician. Without such data, it is difficult if not impossible to accurately interpret some histologic findings. As such, the more dermatopathologists know about the patient from whom a biopsy specimen is being obtained the more accurate their interpretation of the histologic findings may be. We have listed 5 categories of information all beginning with the letter D, which should be available to dermatopathologists as they evaluate a cutaneous biopsy specimen-description, demographics, duration, diameter, and diagnosis. Inclusion of this information with skin biopsy specimens will assist in their accurate and timely interpretation.

Humans↗