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K H Perzin

Publications and source records attributed to K H Perzin.

At least 37 records · Page 2Linked to original sources
PubMed1981

Bilateral nasal squamous carcinoma arising in papillomatosis: report of a case developing after chemotherapy for leukemia.

A patient with a 25-year history of recurrent left nasal polyps is described. Recurrent papillomatosis (schneiderian or inverted papilloma) involving the left nasal cavity had been histologically documented for five years. Following the onset of and chemotherapy for acute myelomonocytic leukemia, the patient developed papillomatosis in the right nasal cavity and invasive squamous cell carcinomas in both nasal cavities. The case may represent the first reported example of apparently separate invasive carcinomas arising in nasal papillomatosis and developing in both the left and right nasal cavities.

Antineoplastic Agents↗
PubMed1981

Adenomas of the small intestine: a clinicopathologic review of 51 cases and a study of their relationship to carcinoma.

The authors studied 51 patients who had small bowel tumors that contained adenomatous epithelium. These rare lesions were identified among 392,000 surgical pathology cases seen during a 62-year period. Grossly and histologically, adenomas arising in the mucosa of the small intestine are similar to the adenomas found in the colon. Of the 51 patients, 18 had adenomas, and 33 had tumors that contained both adenoma and carcinoma in the same lesion, including five intramucosal and 28 invasive carcinomas. The location of the tumor usually determined which clinical problems were produced. The data indicate that adenomas originating in the small bowel mucosa probably are premalignant lesions and that many primary adenocarcinomas of the small intestine arise in adenomas. Of the authors' 130 apparently primary small bowel carcinomas (including the papilla of Vater), 33 (25%) histologically demonstrated adenomatous epithelium in the same lesion. Factors associated with an increased chance of finding carcinoma in an adenoma include adenoma type, size of lesion, location, and multicentricity. Carcinomas appear to develop more frequently in papillary (villous) adenomas than in ordinary adenomas. The larger the lesion is, the more likely carcinoma will be identified. Adenomas involving the ampulla contain carcinoma more often than do lesions found elsewhere in the duodenum and small intestine. Three patients had multiple adenomatous polyps of the small bowel; two of these individuals also had duodenal carcinomas. Various problems in pathologic diagnosis and clinical management are discussed.

Adenocarcinoma↗
PubMed1981

Acinic cell carcinoma arising in nasal cavity: report of a case with ultrastructural observations.

An acinic cell carcinoma (ACC) arising in the nasal cavity, a rare entity, is presented. The tumor involved the left lower turbinate and showed the classic features of ACC on light microscopic examination. On ultrastructural examination, tumor cells contained numerous secretory granules, diagnostic of ACC. Scanning electron microscopy demonstrated the secretory granules as well as numerous apical microvilli where tumor cells surrounded lumens. As far as the authors are aware, the scanning electron microscopic findings in ACC have not been previously reported.

Aged↗
PubMed1981

Pancreatoduodenal resection and total pnacreatectomy--an institutional review.

Between 1940 and 1978, 150 major pancreatic resections--92 pancreatoduodenal resections (PDRs) and 58 total pancreatectomies (TPs)--were performed for benign and malignant disease. The majority of resections were for pancreatic cancer (70 patients) and ampullary cancer (40 patients). The overall operative mortality rate for PDR was 14%; it was 26% for TP. After resection for adenocarcinoma of the head of the pancreas, the operative mortality rate was 28% for TP and 15% for PDR. The number of 5-year survivors after resection for cancer of the head of the pancreas was four (5.7%). Three survived after PDR and one after TP. Of the 42 adenocarcinomas resected by TP, one of the patients had multicentric cancer and two others had carcinoma in situ. TP appears to have no advantage over PDR for cancers of the head of the pancreas from a theoretical or practical standpoint.

Adenocarcinoma↗
PubMed1980

Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): a clinico-pathologic study.

Six cases of a rare entity, lacrimal gland malignant mixed tumor (MMT), or carcinoma arising in benign mixed tumor (BMT), are presented. Clinically, 2 patients had a long history of orbital protrusion, which recently had progressed more rapidly, In 2 other cases, the carcinomas evolved after recurrences of BMT. Two other patients experienced the recent onset of symptoms, without a known tumor previously having been present. Clinical clues suggesting a malignant neoplasm of a lacrimal gland include 1) recent rapid onset of symptoms (orbital protrusion, eyelid swelling; 2) presence of pain; and 3) radiographic studies showing bone destruction. In each of our cases, histologic examination demonstrated a BMT as well as a carcinoma (undifferentiated or poorly differentiated adenocarcinoma; in 1 case, areas of adenoid cystic carcinoma were identified). Problems in histopathologic diagnosis are explored. (BMT, recurrent BMT, in situ carcinoma in BMT and MMT are differentiated.) The management of lacrimal gland tumors is discussed. For a suspected malignant neoplasm, a biopsy through the eye lid to establish the diagnosis is recommended. Radical orbital exenteration should be performed for malignant mixed tumors, which have a poor prognosis.

Adenoma↗
PubMed1980

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinico-pathologic study XI. fibrous histiocytomas.

As part of our review of non-epithelial tumors involving the nasal cavity, paranasal sinuses, and nasopharynx, nine fibrous histiocytomas (FH) are reported. FH probably are derived from undifferentiated mesenchymal stem cells that have the ability to differentiate into two different pathways, one fibroblastic and the other histiocytic. The proportion of these two different elements varies greatly in different lesions. The cell population ranges from cytologically benign (small bland nuclei and no mitoses) to overtly malignant (marked anaplasia and numerous mitoses). Based on our cases and on 12 previously reported tumors, FH involving the upper respiratory passages may cause clinical problems similar to those produced by other soft tissue neoplasms affecting this area, (nasal obstruction, a mass or swelling in the involved area, epistaxis, loosening of teeth, or facial pain). Physical examination may show a mass projecting into the nasal, sinus, or oral civity; facial asymmetry; proptosis; or a periorbital mass. Radiographic studies may demonstrate sinus opacification or cloudiness, a mass, or bone destruction. Treatment has included polypectomy, wide local excision, partial maxillectomy, or radical maxillectomy, depending on the size and extent of the lesion. When involving the upper respiratory passages, FH, if incompletely excised, may recur locally, requiring a more extensive resection. A minority of these tumors have metastasized via lymphatic and/or venous channels. Histologic features appear to correlate with clinical course.

Adolescent↗
PubMed1980

Acinic cell carcinoma arising in ectopic salivary gland tissue.

Two cases of a rare entity, acinic cell carcinomas, which apparently arose primarily from ectopic salivary gland tissue, are presented. Salivary gland ducts and acini frequently may be found incorporated within intraparotid lymph nodes and less commonly within extraglandular cervical nodes. Ectopic salivary glands may also be seen, although rarely, elsewhere in the head and neck area. The most common tumor to arise from intranodal salivary gland tissue is papillary cystadenoma lymphomatosum; however, other salivary gland-type neoplasms rarely may do so. In our cases, one tumor apparently originated primarily within a paraparotid lymph node and the other in the lateral mid- to low-neck area. Neither of our patients had a demonstrable lesion of a major or minor salivary gland; thus their tumors are presumed to have originated primarily from ectopic salivary gland tissue. The clinician and the pathologist should consider the possibility of a neoplasm arising in ectopic tissue when a salivary gland type tumor is identified away from sites where major and minor salivary glands normally are found.

Adolescent↗
PubMed1979

Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologic study. X. Malignant lymphomas.

In our series of 256 nonepithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 21 were apparently primary malignant lymphomas, including 17 ordinary lymphomas and 4 cases of "midline malignant reticulosis." Of the 15 patients who had ordinary lymphomas and had adequate follow-up, 8 died of lymphoma, 4 were living with disseminated disease, 1 died of other causes with persistent lymphoma and only 2 (13%) had no evidence of recurrence at 8 and 9 years after diagnosis. The tumor was controlled in its primary site by radiotherapy in 13 of 14 patients; however, all but 2 of these patients eventually developed disseminated disease. Of the 3 patients who had midline malignant reticulosis (MMR) and had adequate follow-up, all died of disease. MMR represents an unusual variant of malignant lymphoma and often produces the clinical picture of lethal midline granuloma.

Adult↗
PubMed1979

Acinic cell carcinomas arising in salivary glands: a clinicopathologic study.

Fifty-one cases of acinic cell carcinoma (ACC) arising in major and minor salivary glands are reported (primary sites: parotid 37, submandibular, six, and oral cavity, eight.) These lesions usually produced painless slowly growing masses. Of 49 patients with follow-up information, 17 (35%) developed local recurrences following original surgical resection, and two (4%) had locally persistent disease. At last follow-up, 27 patients (55%) never had a recurrence, seven (14%) had experienced local recurrences but the tumors were apparently controlled by further surgical excisions, five (10%) were living with persistent disease, and 10 (20%) had died (one due to local tumor and nine due to metastases, usually to bones and lungs). The determinate 5-, 10- and 15-year survival rates were 78%, 63%, and 44%, respectively. Prognostic factors included: demonstrable tumor on lines of surgical excision, involvement of deep lobe of parotid, size of primary lesion, degree of mitotic activity and nuclear atypia, infiltrative rather than circumscribed borders, and lymph node involvement. Local recurrence was associated with an increased incidence of locally uncontrollable and metastatic disease. Type of initial therapy correlated with prognosis. Locally recurrent or persistent tumor was found in 14 of 15 patients treated with limited local excisions (including one biopsy only). Recurrences were seen in only three of 28 patients treated by wide local excisions and in two of six following radical en bloc resections. Seven of 17 patients with local recurrence were apparently cured by further more extensive resection. Radiotherapy did not appear effective in controlling these neoplasms.

Adolescent↗
PubMed1979

Carcinoid tumors of the appendix. Mesoappendiceal extension and nodal metastases.

Carcinoid of the appendix occurred in 92 of 400,000 surgical pathology specimens covering 70 years, and followed previously reported incidences by age, sex, symptoms, size, localization and histology. Invasion of the mesoappendix occurred in 13 cases, and in two of these, a reoperative ileocolectomy demonstrated regional node metastases. No distant metastases or fatalities appeared. Tumor size correlated with mesoappendiceal invasion. Carcinoid invasion of the mesoappendix may provide a valuable marker for more distant tumor spread, and justify an aggressive surgical approach in selected patients.

Adolescent↗
PubMed1978

Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clinicopathologic study. IX. Plasmacytomas.

Plasmacytomas occasionally may arise in extraosseous sites, of which the upper respiratory tract is the most common. In our series of 256 nonepithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 10 (4%) were apparently primary extramedullary plasmacytomas. Of our patients with adequate follow-up information, four died of disseminated disease 2, 4, 5 and 6 years after the initial diagnosis. One was alive 6 years after diagnosis with locally persistent tumor. Another was living without recurrence 12 years later. Based on our findings and on the cases reported in the literature, extramedullary plasmacytomas arising in the head and neck area may evolve into one of several different patterns. 1) Some patients have localized disease which is apparently controlled (by surgery, radiotherapy or both) and which never recurs locally or becomes disseminated. 2) In some cases, the tumor recurs locally and is controlled by further therapy. 3) Other patients have a locally persistent and aggressive lesion which cannot be eradicated and which eventually leads to the patient's death by uncontrolled local growth. 4) Still other patients eventually develop evidence of plasma cell neoplasms elsewhere in the body and/or multiple myeloma.

Adult↗
PubMed1977

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinico-pathologic study. VII. Myxomas.

In a study of non-epithelial tumors involving the nasal cavity, paranasal sinuses and nasopharynx, 256 lesions, 156 benign and 100 malignant, were identified. Of these, six were classified as myxoma. Myxomas of facial bones, neoplasms of uncertain histogenesis, infiltrate adjacent tissues and if not completely excised will recur locally. In this series, three patients at one time were treated with limited local excisions. Tumor persisted or recurred in all three. Five patients were treated with en bloc resection (following recurrences in two patients). None of these patients subsequently developed recurrent tumor. We believe that myxomas should be widely resected to prevent recurrence. The extent of the surgical resection should depend on the size, extent and location of the lesion.

Adolescent↗
PubMed1977

Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.

Forty-seven cases of malignant mixed tumor (MMT) arising in major and minor salivary glands are presented. By definition, all these lesions contained both a benign mixed tumor (BMT) as well as a malignant neoplasm, usually a poorly differentiated carcinoma. In some cases, the carcinoma developed in a previously untreated salivary gland mass which was known to have been present for many years, others evolved in a recurrent previously resected BMT and still others originated in a previously undetected BMT. Adverse prognostic factors included: carcinomatous involvement of the resection lines, perineural invasion, metastases in lymph nodes, and origin in a major salivary gland. Lesions arising in the palate had a better prognosis as compared to major salivary gland tumors. Some patients died of locally uncontrollable tumor and others because of metastatic disease. Local recurrences of MMT were seen frequently; 18 patients (38%) had a total of 32 local recurrences. Of patients followed five years or more, seven (35%) had died of tumor, 11 (55%) had no evidence of disease, and two (10%) had died of other causes. Prolonged follow-up is required because recurrences and death from tumor may be seen many years following the diagnosis of MMT. Recommendations for therapy are made. Criteria for differentiating MMT from recurrent BMT and from cylindromatous carcinoma are discussed.

Adenocarcinoma↗
PubMed1977

Non-epithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx: a clinicopathologyic study. VIII. Adipose tissue tumors (lipoma and liposarcoma).

In a study of 256 non-epithelial neoplasms involving the nasal cavity, paranasal sinuses and nasopharynx, only two lesions were classified as adipose tissue tumors (one lipoma and one liposarcoma). The lipoma was found incidentally when tissue removed from the maxillary sinus was studied histologically, the patient having been treated with a Caldwell-Luc procedure for maxillary sinusitis. The liposarcoma produced a large mass involving the nasal cavity, maxillary sinus, ethmoid area, hard palate and maxillary, temporal and sphenoid bones. The tumor extended into the cranial cavity and eventually led to the patient's death. The problems involved in histologically differentiating liposarcomas from other lesions are discussed. Even though adipose tissue tumors are among the most common soft tissue neoplasms, these lesions rarely occur in the nasal cavity, paranasal sinuses and nasopharynx.

Adult↗
PubMed1977

Lipomas presenting as parotid tumors.

Eleven cases of lipoma in the parotid region have been reviewed. Nine tumors were found to be compressing the lateral surface of the parotid gland (periparotidlipoma). One lesion was totally surrounded by salivary tissue, and another involved both the superficial and the deep lobes of a parotid gland (intraparotid lipoma). The tail of the gland was involved most frequently (six patients). The tumors were predominantly right sided (eight cases). All patients were treated by surgical excision. Only one tumor has recurred and this has apparently been successfully treated by a reexcision.

Adult↗
PubMed1976

Nonepithelial tumors of the nasal cavity paranasal sinuses, and nasopharynx: a clinicopathologic study. V. Skeletal muscle tumors (rhabdomyoma and rhabdomyosarcoma).

In a study of nonepithelial tumors involving the nasal cavity, paranasal sinuses, and nasopharynx, 19 lesions (three rhabdomyomas, 16 rhabdomyosarcomas) showed skeletal muscle differentiation. The clinical findings associated with these neoplasms are reviewed, the histologic features are illustrated, results of treatment are presented, and clinicopathologic correlations are discussed. The rhabdomyomas grew as localized masses in the nasopharynx, were excised locally, and behaved clinically like benign tumors. The rhabdomyosarcomas were found predominantly in children and were associated with a poor prognosis; most of the patients died within 2 years following diagnosis.

Adolescent↗