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Biomedical subjects

K H Ricken

Publications and source records attributed to K H Ricken.

12 recordsLinked to original sources

Changes in lymphocyte subpopulations after prolonged exercise.

In order to assess the changes in the cellular immune system, 27 healthy male subjects were selected who participate in leisure-time sports and in whom measurements of the lymphocyte subsets in venous blood were carried out before and after a standardized endurance exercise test (EI, 60 minutes in length, intensity: 63% of maximum performance). The percentages of the following parameters were measured: total T-lymphocytes, B-lymphocytes and O-lymphocytes as well as T4-lymphocytes (helper T-lymphocytes, CD4+) and T8-lymphocytes (cytotoxic/suppressor T-lymphocytes, CD8+). In a subgroup consisting of 8 subjects, the parameters indicated above were measured again 24 hours following E. In order to check the reproducibility of the findings, the endurance exercise test was repeated 21/2 weeks later (EII).

Adult↗

[Hypoparathyroidismus following L-asparaginase and vaccinia virus infection. Effect of hypocalcemia on phagocytosis and the function of lymphocytes].

Rabbits, treated with injections of 4000 IU of L-Asparaginase, develop the clinical and chemical signs of hypoparathyroidism. A simultaneous vaccination with vaccinia virus (strain "Elstree") markedly increase the tetanic symptoms ("conditioned deficiency"). L-Asparaginase may influence the cellular immunity by hypocalcemia. Two mechanisms are discussed: 1. the suppression of the phagocytosis, recognizable by the absence of signs for vaccinal allergy by deficiency of macrophages in the intradermal test with inactivated small-pox vaccine. 2. the inhibition of the PHA-induced lymphocyte transformation caused by deficiency of calcium ions.

Alkaline Phosphatase↗

[Fetal vaccinia (author's transl)].

The problems of vaccination in pregnancy are discussed with regard to the specific immunological circumstances of pregnancy and the immunological relationship between the mother and the fetus. In the whole medical literature only 18 cases of fetal vaccinia are described. The author emphasizes that fetal vaccinia is a complication of primovaccination of a pregnant woman. Experiments on rabbits disclosed that the suppression of cellular immunity in the mother may cause prolanged virusemia and thus favour intrauterine infection. Pregnancy is an absolute contraindication for primovaccination against smallpox.

Adult↗