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Biomedical subjects

K H Riessbeck

Publications and source records attributed to K H Riessbeck.

16 recordsLinked to original sources
PubMed1979

Changes in mouse skin cyclic nucleotides during chemical carcinogenesis and tumor response to treatment with BCG, L-Dopa and cyclic DBAMP.

During chemical carcinogenesis by 9, 10-dimethyl 1,2-benzanthracene the cyclic AMP and GMP content was measured in the skin of mice. The tissue of the developing skin tumor is characterized by an elevated cyclic GMP- and a lowered cyclic AMP level. Consequently the quotient of cyclic AMP and GMP is greatly lowered and is discussed as a crucial factor of cell derangement. Complete regression of the tumor is to be achieved by increasing the cyclic AMP levels by means of cyclic DBAMP and L-Dopa in 20% of the experimental animals. Additional stimulation by BCG of the unspecific immune defence has a favourable effect on tumor regression (about 50%). In a different type of tumor (solid Ehrlich carcinoma) it was possible after pretreatment of the mice with L-Dopa, cyclic DBAMP and BCG and after treatment following tumor injection to prevent tumor development in 67% of the animals.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1979

[Cyclic nucleotide concentration changes in different tumors and therapeutic success through increasing the cAMP level].

Changes in the concentration of cyclic AMP as well as cyclic GMP were measured in different murine tumors and in human tumors of varying malignancy. The quotient of cAMP and cGMP seems to be an important parameter for the molecular-biological derangement. Because of the recently much discussed importance of cAMP and cGMP in the immune defence the changes in the concentration of both nucleotides were measured in the T-lymphocytes of tumor patients. Significant changes occurred in patients with malignant melanoma. Investigations of the stimulatibility of the cAMP and cGMP levels revealed a diminished activatibility of the cAMP level and a higher stimulatibility of the cGMP level in the T-lymphocytes of patients with malignant melanoma as compared with those of the controls. On the basis of the working hypothesis that there is a causal relationship between the deranged dualism of cAMP and cGMP in the T-lymphocytes and the failure of the immunological tumor cell defence, an increase in the cAMP level is offered as a possible therapy. Therapeutic results in tumor-bearing mice and first results in melanoma patients are discussed.

Animals↗
PubMed1975

[Diagnosis of bone tumors].

For the prognosis of the relatively rare bone tumours the time of neglect has an essential importance. At every suspicion of a bone tumour a systematic diagnostics which is directed to the clarification of the malignity should be carried out. The anamnesis often contains references which particularly allow an early recognition of the disease. Only the synopsis of anamnestic, clinical and paraclinical, radiological and bioptical findings ascertains the correct diagnosis. The modern diagnostic methods are discussed concerning their differential-diagnostic valency and range of indications. The close collaboration between peripheral and central institutions on the one hand and between surgeons, radiologists and pathologists on the other is necessary to make a certain diagnosis of the bone tumour in shortest time. A national and central register of cases of bone tumours would be recommendable.

Adult↗