Biomedical subjects

K H Türmer

Publications and source records attributed to K H Türmer.

4 recordsLinked to original sources

PubMed1994

[Intra-arterial fluorescein angiography using ophthalmic artery catheter in an experimental model].

BACKGROUND: For the purpose of retinal angiography sodium fluorescein can be applied oral, intravenously or, via special catheters, intraarterially. In the latter procedure the imaging is different, which will be examined in this paper. There come up aspects, which supplement the possibilities of conventional sequence- or videoangiography and contrast the experimental technique of angiography by temperature-sensitive liposomes. MATERIAL AND METHODS: Intraarterial retinal angiography was carried out on 15 rabbits through a microcatheter and fluorescein was applied in different quantities and concentrations. RESULTS: Because of the direct inflow to the retina, the resulting images had more contrast and interference due to recirculating fluorescein was nearly excluded. With increased perfusion pressure, functional tests of circulation were possible. By administering small amounts of fluorescein 10% (0.01-0.02 ml/min) via the catheter, continuous perfusion provided continuous presentation of hemodynamics, by making visible retinal pulsation. CONCLUSIONS: The intraarterial fluorescence-angiography offers a new possibility for evaluating retinal circulation under increased pressure and for analysis of the retinal pulse wave. The procedure gets a clinical perspective by combined therapeutical application.

Animals↗

PubMed1994

[Retinal vasculitis and antiphospholipid antibodies].

Antiphospholipid antibodies (APAb) are often found in systemic lupus erythematosus (LE) (secondary antiphospholipid syndrome), leading to arterial or venous thrombosis. In primary antiphospholipid syndrome other LE-associated symptoms are not detectable. We present the clinical course and therapy of three patients with this rarely reported disease, discussing immunopathology and therapy. Three young patients (28, 29 and 31 years) were seen at the university eye clinic, presenting severe occlusive vasculitis with vitreal haemorrhages and/or thrombosis. The first patient did not respond to any therapy (various immunosuppressives, plasma-pheresis, laser coagulation) and ended up with defective light perception in both eyes. The second patient also had light perception as final outcome in spite of acetylsalicylic acid, steroids and immunosuppression. The third patient established complete reperfusion on an arteriovenous occlusion after haemodilution and acetylsalicylic acid. Antibodies directed against phospholipids interfere with the blood clotting system in many ways (activation and aggregation of thrombocytes, endothelial function, coagulation cascade). The optimal therapy of this severe disease is unclear, suggesting that acetylsalicylic acid seems to be important, while the effect of immunosuppression or steroids is uncertain.

Adult↗

PubMed1993

[Technique of selective, controlled retinal fibrinolysis in a model].

By microcatheterization of the ophthalmic artery it was possible to test a controlled retinal fibrinolysis in the rabbit. Heparin, tolazoline and urokinase were applied through the microcatheter. By continuous administration of highly diluted fluorescein (0.1%), on-line control of the therapeutic effects was available. Treatment was carried out in cycles of enforced perfusion. In 12 main vessel occlusions the rates of flow could nearly be normalized after mobilization of thrombi by combined emergency therapy. An average of 14 cycles of treatment was necessary. The time needed was 40-60 min. With this technique drug therapies of ocular circulation disturbances are testable and controlled emergency treatment of the eye begins to become feasible.

Animals↗

PubMed1990

[The TV head ophthalmoscope for videodocumentation of fundus changes].

The present paper describes the TV head ophthalmoscope, a logical further development in indirect ophthalmoscopy. It comprises a modern indirect binocular head ophthalmoscope and a micro-CCD color camera. The instrument enables all structures on the fundus to be observed as far as the periphery. Objects seen dynamically include detached retina and vitreous membranes. Practical fields of application are retinal detachment surgery and for demonstration and training in indirect ophthalmoscopy.

Humans↗