Biomedical subjects

K Hänninen

Publications and source records attributed to K Hänninen.

At least 19 recordsLinked to original sources

PubMed2006

RGS4 genotype is not associated with antipsychotic medication response in schizophrenia.

The aims of the present study were to compare the allele frequencies of a common single nucleotide polymorphism located upstream of the regulator of G-protein signaling 4 (RGS4) gene (T > G, Rs 951436) in 219 Finnish patients with schizophrenia and in 389 control subjects, to analyze corresponding frequencies between two different subtypes of 93 schizophrenia patients according to their medication response, and to study the effect of this SNP on age at onset in schizophrenia. The RGS4 (T > G, Rs 951436) genotype was not associated with incidence or age at onset in schizophrenia. Neither was the RGS4 genotype associated with medication response with two different subpopulations with schizophrenia.

Adult↗

PubMed2001

Process analysis of fluidized bed granulation.

This study assesses the fluidized bed granulation process for the optimization of a model formulation using in-line near-infrared (NIR) spectroscopy for moisture determination. The granulation process was analyzed using an automated granulator and optimization of the verapamil hydrochloride formulation was performed using a mixture design. The NIR setup with a fixed wavelength detector was applied for moisture measurement. Information from other process measurements, temperature difference between process inlet air and granules (T(diff)), and water content of process air (AH), was also analyzed. The application of in-line NIR provided information related to the amount of water throughout the whole granulation process. This information combined with trend charts of T(diff) and AH enabled the analysis of the different process phases. By this means, we can obtain in-line documentation from all the steps of the processing. The choice of the excipient affected the nature of the solid-water interactions; this resulted in varying process times. NIR moisture measurement combined with temperature and humidity measurements provides a tool for the control of water during fluid bed granulation.

Excipients↗

PubMed2001

Concentrations of monosaccharides in humic substances in the early stages of humification.

Deteriorated liquid packaging board (LPB) and biowaste compost are matrices, mainly consisting of cellulose, in the early stages of humification. Degradative studies on these matrices allow an examination of the role of carbohydrates in the synthesis of humic substances. Samples of different age were collected and divided by extraction into hot water extract (HWE), bitumen, humic acid (HA), fulvic acid (FA) and humin or residual fibre fractions. The following monosaccharides were identified in these fractions: L-arabinose, D-ribose, D-xylose, L-fucose, D-mannose, D-fructose, D-galactose, D-glucose, L-rhamnose and xylitol. The main component in all fractions was glucose. The concentrations of monosaccharides in humic acids (HAs) of LPB ranged from 67 to 503 mg/g of organic matter, and the concentrations in HAs of compost from 52 to 101 mg/g. As a general trend, the concentrations of monosaccharides decreased during LPB degradation and composting in all fractions. At the same time the relative amounts of D-xylose, D-mannose and D-galactose increased in HAs of compost samples.

Cellulose↗

PubMed2000

Cardiac decompensation during an ischemic event weakens the predictive power of myocardial injury markers.

Our objection was to find determinants of long-term outcome in routine data collected for differential diagnosis of suspected acute myocardial infarction. Study population consisted of 263 discharged patients who were initially hospitalized for differential diagnosis of suspected acute myocardial infarction between October 1992 and January 1993. Follow-up time for all cause and cardiac mortality was 5 years. The variables studied as predictors of outcome were computerized ECG, peak creatine kinase isoenzyme MB, peak troponin I, radiographic evidence of pulmonary congestion (cardiac decompensation), treatment for hyperlipidemia, hypertension or diabetes, smoking, previous myocardial infarction, age and gender. Total mortality was 32% at 5 years, of which 77% (64/83) was of cardiac origin. Pulmonary congestion in chest X-ray was the most powerful predictor of outcome (RR=3.3, 95% CI=2.0-5.2, P<0.001). In multivariate analysis congestion (RR=3.3, CI=2.0-5.2) was the only independent predictor of 5-year total mortality in addition to age (RR=1.06, CI=1.04-1.08). These two variables together with previous myocardial infarction (RR=1.9, CI=1.2-3.1) and hyperlipidemia (RR=2. 0, CI=1.1-3.5) were independent predictors of cardiac mortality. Radiographic evidence of cardiac decompensation during hospitalization is a strong and independent predictor of long-term outcome in unselected patients with suspected AMI. The predictive power of cardiac markers is confined to patients without pulmonary congestion.

Aged↗

PubMed1999

Biodeterioration of cardboard-based liquid containers collected for fibre reuse.

Liquid packaging board (LPB) collected in Germany is processed in Finland as recycled fibre and as plastic reject for incineration. The chemical, biological and physical changes occurring in recycled LPB bales were monitored during storage of six and 18 months. The moisture content in the core of the bales ranged from 7% to 53%, and pH values varied from 6.0 to 8.5. The average amount of mesophilic bacteria per container was 1.5 x 10(7) - 5 x 10(8), which means that recycled LPB pulp cannot be recommended for sanitary use. The concentration of CO2 inside the bale is an indicator of the activity of aerobic microorganisms and might be suitable for identifying deteriorated bales and removing them from the production line. Insects were found in some bales and the more deteriorated the bale was the more species of insects were found. The results showed the conversion of cellulose into humic acids to be clearly underway in some recycled LPB bales. The bale samples were extracted into hot water and into fulvic acids and humic acid (HA) fractions. The concentration of the humic acid fraction varied in the range 0.3-0.6% of the organic matter in fresh bales and 2.2% in one old bale. During aging nitrogen was enriched in all fractions.

Animals↗

PubMed1999

Polymorphisms of the interleukin-1 gene complex in schizophrenia.

Activation of the inflammatory response system has been related to the pathophysiology of schizophrenia by several recent studies. Schizophrenic patients have varied levels of proinflammatory cytokines, such as interleukin (IL)-1, -6, and tumor necrosis factor (TNF)alpha in their peripheral blood or cerebrospinal fluid. These cytokines can modify the metabolism of neurotransmitters, influence neural development, and IL-1 has been implicated in acute, and, on the other hand, chronic neurodegeneration. They could therefore be of primary pathogenic importance, either in the acute disease or during those stages of brain development which possibly influence the sensitivity of a person to schizophrenia in later life. The cytokine regulation of brain development and its possible neuroimmune involvement in the pathogenesis of schizophrenia has been raised. One indication of the pathogenic role of IL-1 in schizophrenia would be a demonstration of the difference between schizophrenic patients and healthy controls at the gene level. Therefore we analyzed the polymorphism of the IL-1 gene complex in 50 schizophrenic patients and in 400 healthy blood donors. The following allelisms were analyzed: IL-1beta gene: base exchange polymorphisms at the positions -511 (relative to the transcriptional start site); IL-1alpha gene: base exchange polymorphism at the position -889; IL-1 receptor antagonist (IL-1RA) gene: variable numbers of 86-base pair tandem repeats in intron 2. The frequencies of the IL-1beta (-511) allele 1, IL-1alpha (-889) allele 2, and IL-1RA allele 1 were somewhat, but not significantly, higher in the schizophrenic patients as compared to the controls. These alleles are known to be located on the same haplotype. The number of carriers of this haplotype was significantly higher in the schizophrenia patients (17/50 vs 81/400) than in the controls (P=0.026, chi2). The frequencies of this haplotype were 0.38 and 0.27, respectively (P=0.0266, chi2). The number of homozygotes of this haplotype was significantly higher in the schizophrenia patients (P=0.0006, chi2). These data suggest that the cytokine aberrations in schizophrenia are, at least partly, genetically determined.

Adult↗

PubMed1998

Socioeconomic variation in back and joint pain in Finland.

UNLABELLED: Differences in the prevalence of back and joint pain by occupational class and education were studied in surveys representative of adult Finns. The effects of lifestyle factors and mental distress on these differences were also analysed. The material comprised 3915 women and 3629 men, all occupationally active. Occupational class and level of education were associated with back and joint pain; the associations were more obvious in men than in women. Among men, the age-adjusted odds ratio of joint pain in farmers was 3.2 (95% CI: 2.1-5.0), in manual workers 2.6 (1.9-3.6), in entrepreneurs 2.4 (1.5-3.7) and in lower white-collar workers 1.7 (1.1-2.4) as compared with upper white-collar employees. Similar odds ratios of back pain were 2.1 (1.6-2.9) in farmers, 1.8 (1.5-2.3) in manual workers, 1.7 (1.2-2.4) in entrepreneurs and 1.4 (1.1-1.7) in lower white-collar workers. Most of the associations persisted in multivariate analyses, in which height, marital status, lifestyle (smoking, leisure-time physical activity and body mass index (BMI)) and mental distress were considered; in these models, mental distress was consistently associated with pain. Back pain was associated with smoking in men and with BMI in women; BMI was also associated with joint pain in both sexes. In women, height showed an association with back pain for which a doctor had been consulted. Marital status, alcohol consumption, leisure-time physical activity and the urbanization level of the community were not important as determinants of pain. CONCLUSION: Obvious differences occurred in back and joint pain by indicators of social class that were not due to socioeconomic differences in lifestyle, height or mental distress.

Adult↗

PubMed1994

Characterization of the humic material formed by composting of domestic and industrial biowastes. Part 1. HPLC of the cupric oxide oxidation products from humic acids.

The changes induced by humification of anaerobically digested sewage sludge, source separated biowaste, and pulp mill biosludge were determined by extracting the fractions of bitumen and humic and fulvic acids from the samples of fresh and humified composts. In all cases, a distinct decrease in the amount of bitumen could be detected during humification. The amount of humic acids increased in sewage sludge and biowaste samples, but decreased in pulp mill biosludge sample during humification. The humic acids were degraded by CuO oxidation and the phenolic degradation products were analysed by reversed-phase high-performance liquid chromatography. The yield of these aromatic degradation products was in the range 0.9-2.0% for each sample. The main phenolic degradation products were 4-hydroxybenzoic acid, vanillic acid, 4-hydroxybenzaldehyde, vanillin, syringaldehyde, and acetovanillone. Two lignin dimers, dehydrodivanillin and dehydrodiacetovanillone, were also identified.

Chromatography, High Pressure Liquid↗

PubMed1994

Seven-year follow-up of white-finger symptoms and radiographic wrist findings in lumberjacks and referents.

OBJECTIVES: In 1978, a cross-sectional study of 279 lumberjacks exposed to hand-arm vibration and 178 unexposed referents was conducted. The aim of the present study was to provide a seven-year follow-up on (i) the changes in the white-finger symptoms among the lumberjacks and the referents, (ii) the effect of white-finger symptoms on the professional prognosis of the lumberjacks, and (iii) the relationship between hand-arm vibration and changes in wrist bones. METHODS: The methods consisted of a questionnaire, a routine clinical examination, and radiographs of the wrists and hands. The examinations were conducted as a field study using a mobile unit. RESULTS: The prevalence of white-finger symptoms was 18% among the lumberjacks and 3% among the referents in the original study. Seven years later 213 lumberjacks and 140 referents participated in the follow-up. The prevalence of white-finger symptoms was 24.9 among the lumberjacks and 5.7 among the referents, and the seven-year cumulative incidence was 14.7% among the lumberjacks and 2.3% among the referents. After allowance for age, there was no difference in the incidence of white-finger symptoms between the lumberjacks with fewer than 15 years of exposure and the referents, but the risk increased with increasing duration of exposure (risk ratio 8.9, 95% confidence interval 2.5-28.9 for those exposed at least 25 years). There was no difference between the two groups in the prevalence of radiographically detectable translucencies or osteoarthrotic changes in the wrists and hands. CONCLUSION: According to the results, white-finger symptoms are still a problem among lumberjacks who started chain-saw work before 1970.

Adult↗

PubMed1994

Knee laxity in carpet and floor layers and painters.

The knees of 154 carpet and floor layers and 131 painters were examined clinically and the anteroposterior displacement of the knees was measured with a computer-based arthrometer. The drawer test, the pivot shift and the thigh muscle stretching tests showed greater mobility among carpet and floor layers than among painters. The arthrometric examination showed equal anteroposterior tibiofemoral displacements in the two groups. Two percent of the subjects had a right knee/left knee difference indicating a cruciate ligament insufficiency. Tightness in the rectus femoris stretching test, and among carpet and floor layers also radiographic tibiofemoral osteophytosis predicted small arthrometric changes.

Adult↗

PubMed1994

Knee disorders in carpet and floor layers and painters. Part II: Knee symptoms and patellofemoral indices.

One hundred and sixty-eight carpet and floor layers and 146 painters were examined with the aid of a questionnaire, clinical tests of the patellofemoral joint, a knee exertion test and measurements of patellofemoral indices. Carpet and floor layers reported previous knee conditions more frequently than painters. Patellofemoral tenderness was not related to occupation, patellofemoral indices or perceived knee conditions. On the contrary, pain in the knee exertion test of 50 squats was related to perceived knee injuries and pain on compression of the patella. Exertion test seems to be more accurate than traditional clinical tests in the screening of knee lesions.

Adult↗

PubMed1992

Knee disorders in carpet and floor layers and painters.

In an evaluation of the effect of kneeling work on the knees, 168 actively working carpet and floor layers and 146 house painters were examined with the aid of a questionnaire, a clinical examination, and radiography. Reported knee pain, knee accidents, and treatment regimens for the knees were more common among the carpet and floor layers than among the painters. Radiographic changes of the tibiofemoral joint were noted equally in the two occupational groups, but osteophytes of the patella were more common among the carpet and floor layers than among the painters. In a multivariate analysis, the determinants of osteophytosis of the knee were age, occupation, knee accidents, and smoking, and osteophytosis may be due to more frequent workbreaks from kneeling postures among smoking workers. This study indicates that kneeling work increases the risk of knee disorders and such radiographic changes that might be an initial sign of knee degeneration.

Accidents, Occupational↗

PubMed1990

Radiographically detectable degenerative changes of the lumbar spine among concrete reinforcement workers and house painters.

In this study of lumbar degeneration and the role of mechanical loading in its development, lateral lumbar radiographs of 216 concrete reinforcement workers and 201 house painters aged 25-54 years were examined. Disc space narrowing occurred at about 10 years and spondylophytes at about 5 years younger age in the former than in the latter group. Risk ratios (RR) were estimated from the regression coefficients of logistic regression models. RR for the univariate effect of occupation on disc space narrowing was 1.8, and adjustment for age, earlier back accidents, height, body mass index and smoking had only a minor effect on this relationship, adjusted RR 1.8. The crude RR for spondylophytes was 1.5, and the adjusted RR 1.6. Earlier back accidents showed a significant univariate relationship with DSN, but in multivariate analysis this variate did not retain its significance. It was concluded that heavy physical work enhances the degenerative process of the lumbar spine. Materials handling and postural loading are proposed to be occupational factors of importance in the development of both disc space narrowing and spondylophytes.

Adult↗

PubMed1989

Predictors of sciatic pain among concrete reinforcement workers and house painters--a five-year follow-up.

In a study of the association of occupation and several other determinants with the occurrence of sciatic pain, 167 concrete reinforcement workers and 161 house painters were followed for five years. Base-line data were obtained with a questionnaire, an interview on back symptoms, a clinical examination, and a radiograph of the lumbar spine. Follow-up data on back symptoms were obtained with a postal questionnaire. Concrete reinforcement work was associated with an increase in the risk of sciatic pain, in both a cross-sectional and a prospective study. Reported back accidents contributed to the risk of sciatic pain. Previous history of back symptoms was the most powerful predictor of sciatic pain prospectively. Degenerative changes were related to sciatic pain in retrospect, but prospectively this relationship was weaker. Body height and history of stress episodes showed some association with sciatic pain; abdominal muscle strength, body mass index, and smoking did not; and back muscle strength was associated only retrospectively.

Adult↗

PubMed1989

Radiographically detectable lumbar degenerative changes as risk indicators of back pain. A cross-sectional epidemiologic study of concrete reinforcement workers and house painters.

The association between radiographically detectable degenerative changes in the lumbar spine and back symptoms was studied, along with the possible effect of occupational work load. The subjects were 216 concrete reinforcement workers and 201 house painters. A questionnaire provided information on work history and earlier back accidents, and a standardized interview produced data on back symptoms. The occurrence of disc space narrowing, anterior and posterior spondylophytes, and end-plate sclerosis was recorded separately for each intervertebral space from lateral lumbar radiographs. Moderate to severe degenerative changes were associated with increased risk of sciatic pain but not with the occurrence of lumbago or nonspecific back pain. The different types of degenerative changes provided no further information. In a multivariate logistic regression analysis degenerative changes and earlier back accidents were significant independent predictors of sciatic pain. When these two variates were allowed for, the effect of occupation was not significant.

Adult↗

PubMed1989

Low-back pain and occupation. A cross-sectional questionnaire study of men in machine operating, dynamic physical work, and sedentary work.

The frequency of sciatic pain, lumbago, and nonspecific low-back pain (LBP) and factors related to these symptoms were determined among men occupied in machine operating (541 longshoremen and 311 earthmover operators), dynamic physical work (696 carpenters), and sedentary work (674 municipal office workers). Sciatic pain was more common among machine operators and carpenters than among office workers, and also more frequent among machine operators than among carpenters. The occupational differences were considerably smaller with regard to lumbago and nonspecific LBP. In multivariate analysis, occupation, age, reported back accidents, and postural load showed significant independent effects on the occurrence of sciatic pain. Allowing for other risk indicators, the relative risk was 1.3 contrasting machine operators with both office workers and carpenters, but carpenters had no excess risk as compared with office workers.

Absenteeism↗

PubMed1988

Neck and shoulder symptoms among men in machine operating, dynamic physical work and sedentary work.

Data on the occurrence of neck and shoulder symptoms and some qualities of work and leisure-time activities were gathered with a postal questionnaire sent to 1,174 machine operators, 1,045 carpenters, and 1,013 office workers. They were all men in the age range of 25-49 years. The response rate was 67-76%. The lifetime cumulative incidence of neck and shoulder symptoms was 81% for the machine operators, 73% for the carpenters, and 57% for the office workers. About half of the two groups of manual workers and 24% of the office workers had had symptoms during the last 7 d. Pain in the arms was indicated by 14-17% of the manual workers and 4% of the office workers. Symptoms during more than 30 d within the last 12 months were also more common among the manual workers than among the office workers. Within the manual worker groups, the machine operators had more symptoms than the carpenters. In a multivariate logistic regression analysis occupation, working in twisted or bent postures, age, draft, and job satisfaction proved to be significant risk indicators for neck and shoulder symptoms.

Adult↗

PubMed1987

Determination of sciatica in epidemiologic research.

The international classification of diseases is unsuitable for epidemiologic research on the etiology of degenerative back disease. In cross-sectional studies of occupationally active populations, the occurrence of various symptoms and signs of back disease may be established. However, recommendations as to what data to gather or how to combine it into meaningful entireties are not yet established. To validate reported sciatic pain by clinical findings, 252 reinforcement workers and 231 painters, all men, 20-64 years of age, were examined by nine tests. In the reinforcement workers exposed to heavy occupational loads the reports of sciatica during the previous month were clearly related to several clinical findings. The tests for restriction and pain on bending forward and sideward gave sensitivity values of 0.36-0.61 and specificity values of 0.82-0.87. Combining the results of the separate tests into pairs enhanced the sensitivity to 0.62-0.68, but reduced the specificity to 0.77-0.78. Referring to the current results, recommendations include a structured inquiry into sciatic pain during the previous month, backed up by clinical tests for range of and pain on lumbar movement, when studying the occurrence of back syndromes in physically heavy trades.

Adult↗