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K Höfner

Publications and source records attributed to K Höfner.

60 records · Page 4Linked to original sources
PubMed1989

[Urinary continence in the female--a morphologic study].

Physiological studies which can be traced back into the last century have produced a large number of theories on continence and micturition. A literature review may cause some doubts on the clinical applicability of these theories. Not considering the disagreement on the morphology of the lower urinary tract, many questions like the functional interpretation of morphological findings remain unanswered. A renewed morphological study of the urinary bladder neck and its adjacent structures in males and females were done. The histological examination of 30,000 serial sections have revealed a widely different morphological structure in comparison with the literature. Additional muscular systems were identified, new defined and their possible function was discussed.

Connective Tissue↗
PubMed1986

[Effect of Mictonorm (propiverin hydrochloride) on the female urethra].

In a study about drug-induced changes of the urodynamics of the female urethra by Mictonorm 14 women with urge-symptoms were investigated. According to a special examination plan the control of Mictonorm-effect was realized with the analysis of the parameters of the urethra pressure profile at rest and under stress conditions and of the vesico-urethral pressure transmission. The result shows that there were no significant changes of the urodynamics of the female urethra, therefore one can accept selective detrusor effects by oral application.

Adult↗
PubMed1985

[Changes induced by Mictonorm in the urodynamics of the detrusor muscle in females with symptoms of the urge to urinate].

In a study for the recognition of the urodynamics of the detrusor after administration of the anticholinergic drug Mictonorm 14 patients with obstinate urge symptoms were examined. According to an examination plan every woman underwent three cystometric examinations each which were performed by means of a special urodynamic measuring device. Apart from a distinct improvement of the subjective complaints with the help of significantly different cystometry parameters the change of the urodynamics of the detrusor after therapy may be made evident in the results.

Adult↗
PubMed1984

[Urodynamic measurements of the lower urinary tract--technical realization and implications for the interpretation of findings].

technique of urodynamic measurement is presented which allows both screening and complex measurements to be carried out by a choice of variably combinable individual parameters, exclusively on the basis of GDR instruments and taking into account the unity of the basic functions: collection of urine, miction and continence. Ways in which the readings can be influenced by the methods used are pointed out. A standardized course of examination for complex urodynamic measurement is presented.

Adult↗
PubMedDate not supplied

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.

For prostate cancer, allelic deletions from the long arm of chromosome 10 (#10q23-25), the locus of the putative tumor suppressor gene MXI1 (#10q24-25), have been identified as a frequently occurring genetic event. During the development of several human malignancies, the c-myc proto-oncogene has been identified to enhance cellular transformation, mitogenesis and cell proliferation. The MXI1 gene, belonging to the helix-loop-helix (bHLH) gene family, was demonstrated to display tumor suppressor function by antagonizing c-myc induced transcriptional activities. Due to the detection of point mutations in the retained alleles of four primary adenocarcinomas of the prostate, MXI1 gene alterations have been suggested to be involved in the development and/or the progression of prostate cancer. To evaluate the role of MXI1 gene alterations for the development of adenocarcinoma of the prostate, 42 primary prostate cancers of different stage (T1-4) and histological grade (G1-3) were investigated for alterations within exons 4 and 5 of the MXI1 gene (spanning 6 exons in total), encoding for the functional HLH-Zip domain, by RNA-SSCP analysis and direct PCR-DNA-sequencing following the microscopically guided tumor cell dissection from 5 microm fresh-frozen buffer-soaked tissue sections. Even by application of this highly elaborated technical approach, MXI1 gene alterations could not be deleted in any of the tumor specimens investigated. Therefore, a substantial involvement of MXI1 gene alterations in the development of prostate cancer appears unlikely. The newly identified putative tumor suppressor gene PTEN, located at #10q23, might be responsible for the frequently observed allelic deletions from #10q23-25 in prostate cancer.

Adenocarcinoma↗