PubMed Health⌕ Search

Biomedical subjects

K Hübner

Publications and source records attributed to K Hübner.

At least 109 records · Page 6Linked to original sources
PubMed1976

Myelopoietic cell proliferation in granulocytopenia of refractory anaemia and preleukemia states with hyper-plastic bone marrow.

Myelopoiesis in healthy subjects and in 8 cases of refractory anaemia or preleukemia states was studied by the combined cytophotometric-autoradirgraphic method. Granulocytopenia was present in 7 of 8 cases. The results can be summarized as follows: 1. Mature myelocytes of healthy persons are a mainly differentiating cell population with a low labelling index (3-10%) and a high incidence in G1-Phase. 2. The proliferating immature granulopoietic cells of the patients with neutropenia showed a reduced labelling index with 3H-thymidine as a result of an arrest of these cells in G1 (6 of 8 cases). 3. A similar result was obtained in the study of the hyperplastic myelopoiesis of an other patient with preleukemia and normal granulocyte count in peripheral blood, with the disturbance of cell proliferation preceding the symptom neutropenia. 4. Finally in only one case an increased frequency of myelopoietic cells in G2-phase was found suggesting an arrest of cell proliferation in the premitotic phase.

Adult↗
PubMed1976

Proliferative activity of undifferentiated cells (blast cells) in preleukaemia.

Undifferentiated cells (blast cells) in preleukaemic states show labelling indices comparable to those of leukaemic blast cells. Since this cell population can remain constant over months or even years, a steady state must exist between the production of blast cells and cell death. It is more likely, however, that in preleukaemic conditions, blast cells may differentiate to morphologic 'normal' haemopoietic cells. The fact that the latter show an impaired cell proliferation supports the view that they derive from an affected stem cell compartment.

Adult↗
PubMed1975

[Indication for surgery in lumbar disk displacement].

After the description of the operative risk and the results of the operation in the lumbar dislocation of the disk the indications for an operation are demonstrated. According to our experiences the indication for the operation of disks may be a necessity in a part of patients, in order to avert remaining lesions. In a second group the operation should be carried out, since conservative measures cannot bring about a change of the complex of complaints and, apart from this, may be dangerous for the patient. In the third group the operation can be indicated, as after conservative treatment recidivations may appear again and again. The contraindications are described in short and our indication for lumbar myelography is demonstrated.

Humans↗
PubMed1975

Proliferation of ineffective erythropoiesis with nuclear abnormalities and megaloblastoid appearance in preleukaemia.

Erythropoiesis of two patients in the early stage of acute leukaemia and two patients with refractory anaemia and hypercellular bone marrow (preleukaemia?) was studied with the cytophotometric-autoradiographic method. Megaloblastoid erythroblasts show a decreased proliferative activity in comparison to the morphologically normal cells and are in the maturation stage of E4 (early polychromatic normoblasts) mainly in the G1-phase; they are therefore largely comparable to the megaloblastoid erythroblasts in erythroleukaemia. Erythroblasts in preleukaemia with nuclear abnormalities are found in a high percentage in the G2-phase or are unlabelled with a DNA content of between diploid and tetraploid value. They show a similar proliferative behaviour to the megaloblasts in pernicious anaemia. Early polychromatic erythroblasts arrested in G2-phase can differentiate without mitosis into tetraploid mature erythroblasts (E5). They can divide elsewhere endomitotically, produce binucleated E5 or take up the DNA synthesis and become polyploid. E4 with nuclear abnormalities do not proliferate and are mainly found in the premitotic phase.

Acute Disease↗
PubMed1975

Some aspects of erythropoietic cell proliferation in erythroleukaemia.

Cytophotometric-autoradiographic investigations on erythropoiesis in erythroleukaemia indicate (1) the decreased labelling index of erythroblasts is explained by an increased percentage of these cells in G-i; (2) 'megaloblastoid' basophilic erythroblasts show a more pronounced decrease of their fraction in DNA synthesis than morphological normal cells; (3) 'megaloblastoid' early polychromatic normoblasts represent a non-proliferating cell population, and (4) the detected disturbance of cell proliferation - even though temporary - can be reversed.

Adolescent↗