Biomedical subjects
Publications and source records attributed to K Habel.
Participation motives were investigated in 81 Australian-born and 42 overseas-born older Australians (M age = 67.8 yr.) involved in community-organised exercise programs. Australians born overseas scored significantly higher on factors of Affiliation/Personal, Recognition/Achievement, and Exercise Involvement of the Participation Motivation Questionnaire but not on Fitness.
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With a view to establishing whether rabies antiserum derived from a species genetically identical to a challenged recipient would increase or decrease its effectiveness compared with that of allogeneic antiserum, rabies immune sera produced in an inbred strain of mice and in donkeys were tested, either alone or with a course of vaccine inoculations, in mice of the same strain a few hours after intramuscular challenge with fixed CVS rabies virus. Surviving mice were bled at intervals over a year and the rabies antibodies assayed in pooled sera.There was no evidence that the isogeneic antiserum was either more or less effective than the allogeneic, nor was there a difference between the two in the decay of passive antibody; similarly, there was no marked difference in their ability to interfere with the active production of antibody resulting from the highly potent vaccine used.
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Early and persistent antibody is needed for maximum protection to be afforded to persons severely exposed to rabies. With vaccine alone, detectable antibody production takes 7-10 days, and the passive antibody introduced with antirabies serum or gamma-globulin is commonly used to fill this gap. However, administration of antirabies serum or gamma-globulin with vaccine interferes with the antigenic action of the vaccine.The studies reported in this paper provide further evidence that the interfering effect of serum can be overcome by giving booster doses of vaccine, as recommended by the WHO Expert Committee on Rabies, 10 and 20 days after the end of the usual 12- to 14-dose series of vaccine inoculations. While the results do not clearly indicate whether a single booster dose might be sufficient, the authors consider the second booster useful to ensure both degree and length of antibody duration.
The immunofluorescent demonstration of polyoma tumor antigens in tumor cells requires a heatlabile serum component. With unheated hamster tumor serum, specific fluorescence was observed in polyoma-transformed hamster, mouse, and rat tumor cells. Heated serum usually gave little or no reactivity; the activity of such heated serum could be restored simply by the addition of fresh normal unheated hamster serum.