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Biomedical subjects

K Handa

Publications and source records attributed to K Handa.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Evaluation of 201Tl-accumulation in lung--imaging of 201Tl in the extravascular space (author's transl)].

In order to evaluate 201Tl-accumulation in lung, 201Tl imaging was performed using a scintillation camera coupling to a small digital computer, and blood clearance of it was examined. After the injection of 74 MBq(2mCi) of 201Tl-chloride, the serial images and static images were obtained. In order to obtain the image of 201Tl in the extravascular space [TE(x, y)], a subtraction technique was performed as follows; after 2 anterior views of 201Tl were obtained using a 20% window centered at 80 keV [T0(x, y)] and 140 keV [T140(x, y)] respectively, and blood sample was taken, radionuclide angiocardiography with 185 MBq (5 mCi) of 99mTc-human serum albumin and it's static image were done in the same supine position and blood sample was taken too. The radioactivity of 201Tl(T) and 99mTc(HB) in the blood was counted by a autogamma scintillation counter. Then the image of TE(x, y) was obtained by the following formula; TE(x, y)=T0(x, y)-[H(x, y)-T140(x, y)]TB/HB. Following results were obtained; (1) The disappearance of 201Tl from the blood was rapid and 15 min after the injection only 10 approximately 15% of the activity after 1 min was present in the blood. (2) The lung activity in the time activity curve decreased rapidly to reach plateau within 100 approximately 150 sec after the injection. (3) The image of 201Tl in the extravascular space was nearly equal to the original one as regard to the radioactivity of 201Tl in lung.

Adult↗
PubMed1982

[A technique for quantifying lung uptake of 201Tl on the scintigram with 201TlCl].

On intravenous administration of 201TlCl (74 MBq (2 mCi), initial transit of it through the heart as well as subsequent uptake by the chest were recorded in the supine position using a scintillation camera coupling to a small digital computer, and remaining the patient in the same position perfusion scintigram with 99mTc-macroaggregated albumin (MAA) or transmission scintigram with a point source of 99mTcO4- too. The radioactivity of total injected dose of 201Tl (T) was calculated from the entire region on the initial transit of the tracer bolus through the heart, and that of unilateral lung (L) was done from the anterior image of 201Tl on which isocount map of the perfusion image or transmission one was superimposed. By these procedures, the lung uptake ratio of 201Tl was calculated by ratio of L/T, and expressed as percentage per entire unilateral lung and mean value (%) per pixel. The average values of the lung uptake ratio in circulatory diseases were 4.0 +/- 1.2% in the right lung, 2.7 +/- 1.2% in the left lung, and in respiratory diseases 4.5 +/- 2.1% and 2.3 +/- 1.0%, respectively. This technique is useful to quantify the lung uptake of 201Tl on the lung scintigram with 201TlCl.

Adult↗
PubMed1980

A radiotherapeutic clinical trial of twice per week vs. five times per week in oral cancer.

135 cases of oral cancer have been treated by two fractions per week, and the results are compared with 115 approximately identical cases treated by conventional five days a week schedule with other parameters being identical. Radical irradiation was done by 6000 and 6500 rd in 6--6 1/2 weeks (NSD 1800--1900 ret) and palliative dose was 4500 R/4 weeks (NSD 1532 ret). Tumour regression was found markedly superior by conventional regime in radically irradiated cases but much less superior for palliative treatment. Acute and late reaction as well as tumour control at 1 year was better with daily treatment, more so in cases treated for radical cure, while in palliative treatment, the superiority of daily regime was less marked. Our study provides evidence that only for palliation in advanced cases, radiation therapy by 2 fractions a week can be alternatively used.

Adult↗
PubMed1979

[Imaging of the bronchial blood flow usingg RI-angiography--study on its procedure and application of dual radioisotope technique (author's transl)].

RI-angiography with 99mTcO4- was carried out using a scintillation camera with a digital minicomputer for the purpose of imaging of bronchial blood flow in various lung diseases, and as application of dual radioisotope techniques, other imagings such as tumor imaging with 197HgCl2 or 67Ga-citrate and/or perfusion imaging with 99mTc-MAA, were performed simultaneously in patients remaining the same position, too. The image as a iso-count map extracted out of the image of 197HgCl2, 67Ga-citrate or 99mTc-MAA, was superimposed to the brightness image of RI-anigogram (aortic phase). By these procedures, the image of bronchial blood flow were obtained in some patients with lung cancer, pulmonary tuberculosis, lung abscess, and chronic bronchitis. The dual radioisotope techniques using RI-angiography and the other imaging were useful to make isotope diagnosis of lung diseases more reliable, and the image superimposition methods using RI-angiogram and the image of tumor or perfusion, were useful to improve anatomic orientation of the former.

Bronchial Arteries↗
PubMed1979

[Myocardial imaging with thallium-201--subtraction imaging with 201TlCl and 99mTcO4- for the visualization of the right ventricle--(author's transl)].

The dual radioisotope techniques with 201TlCl and 99mTcO4- were performed in 30 cases inclusive of various heart and lung diseases, using a scintillation camera coupling to a small digital computer. The scintigraphic procedures were started about 5 minutes after intravenous injection of 201TlCl. The myocardial images such as anterior, 60 degrees left anterior oblique, and left lateral view, were obtained. Next, 30 degrees left anterior oblique view was taken and radionuclide angiogram with 99mTcO4- was done in the same position too. This joint use of the myocardial imaging and radionuclide angiography could increase diagnostic reliability. Superimposing the image as iso-count map extracted out of radionuclide angiogram to the brightness image of 201TlCl, the anatomic orientation of the image of 201TlCl was improved. Subtracting the blood pool image with 99mTcO4- or radionuclide angiogram, which showed visualization of the right ventricle, lungs and left ventricle, from the image of 201TlCl, the subtraction image was obtained. The right ventricle was visualized more clearly on this subtraction image than the original image of 201TlCl. Good visualization of the right ventricle was shown in 25 cases on the subtraction image, and in 17 cases on the original image of 201TlCl.

Adult↗
PubMed1977

Target cells for interferon production in human leukocytes stimulated by sendai virus.

Whole leukocytes, mononuclear cells, polymorphonuclear cells (PMN), MONOCYTES, PURIFIED LYMPHOCYTES, AND T (rosette-forming cells, RFC) and non-T (nonrosette-forming cells, nonRFC) lymphocytes isolated from the human peripheral blood were stimulated by Sendai virus, respectively, and examined for interferon production in their culture fluids. High levels of interferon were produced by mononuclear cells, but not by PMN. Removal of monocytes from the mononuclear cell population did not affect at all the levels of interferon produced, although it strongly suppressed interferon induction by polyinosinic-polycytidylic acid (poly IC) and mitogenic response to phytohemagglutinin (PHA) of the lymphocytes. Purified monocytes and T lymphocytes were unresponsive to the virus. In contrast, a population of purified non-T lymphocytes produced high levels of interferon. Addition of monocytes to the interferon-producing non-T lymphocytes did not affect the levels of interferon produced. No detectable levels of interferon were produced in the mixture of T lymphocytes and monocytes. It is concluded that non-T lymphocytes may be a major target for interferon induction of human leukocytes by Sendai virus.

Cell Separation↗