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Biomedical subjects

K Hasler

Publications and source records attributed to K Hasler.

At least 19 recordsLinked to original sources
PubMed1991

Factor XIII-deficiency in the blood of venous leg ulcer patients.

Pericapillary fibrin cuffs are probably involved in the pathogenesis of venous leg ulcers. Factor XIII (Fibrin stabilizing factor) is of importance in wound healing. Its activity, which may affect ulceration, was found to be significantly reduced in the blood of venous leg ulcer patients and in post-phlebitic patients, compared with healthy controls.

Chronic Disease↗
PubMed1990

["Lupus anticoagulant" in immune hyperthyroidism].

A 56-year-old woman with autoimmune hyperthyroidism (Basedow) whose blood coagulation had at first been normal developed prolonged partial thromboplastin time (PTT) of 48 s and a fall in prothrombin time (Quick value) to 52%. At the same time, total activity of factor VIII was reduced to 18% and factor IX to 16%. These values not having changed after the addition of normal plasma, it is assumed that an acquired inhibitor of plasmatic coagulation was responsible. Such inhibitors were first described in lupus erythematodes and therefore called lupus anticoagulant, but later also demonstrated in other autoimmune diseases.

Autoantibodies↗
PubMed1989

Long-term results of percutaneous transluminal angioplasty: a study of 4750 dilatations and local lyses.

During a period of 8 years 4750 percutaneous transluminal angioplasties and local lyses have been performed in the Department of Radiology of the University of Freiburg and the Hochrheinklinik Bad Sackingen. From 1984 to 1987 all patients have been assessed clinically and in 320 cases angiographically. Lesions were localised mainly to the pelvic and the femoro-popliteal regions. The short and long term results have been compared, i.e. 2-8 years after PTA. Patients with occlusive disease from stage IIa to stage IV were treated. Long-term success of PTA (2-8 years after the intervention) reached 85% in stage IIa, 73% in stage IIb, 68% in stage III and 36% in stage IV, when all treated lesions were included.

Angioplasty, Balloon↗
PubMed1989

[Disseminated intravascular coagulation disorder in the 2d trimester of pregnancy. Case report from the 16th week of pregnancy with spontaneous parturition at term].

After exercising on a trampoline, a 29-year-old primigravidae in the 16th week of gestation was admitted to our hospital with the clinical signs of premature ablatio placentae and acute coagulation disturbances with disseminated intravascular coagulation and uncontrolled secondary hyperfibrinolysis. The coagulation disturbance was stabilized by conservative therapy (Substitution with fresh-frozen-plasma (ffp), whole blood and low-dose heparin treatment without having to terminate the pregnancy by evacuation of the uterus. An appropriate antifibrinolytic treatment was not performed in this case. The continuous controls of fibrinmonomeres and reptilase time indicate the possibility of a persisting latent coagulation disturbance after the acute phase. Thus, the necessity of a low-dose heparin therapy after an acute coagulation disturbance becomes evident.

Abortion, Threatened↗
PubMed1986

Alpha-2-adrenoreceptor density on intact platelets and adrenaline-induced platelet aggregation in endurance- and nonendurance-trained subjects.

Alpha-2-adrenoreceptor density on intact platelets was evaluated in 17 sportsmen, 8 of whom were endurance-trained athletes. Receptor density was determined as being equivalent to 3H-Yohimbine, specifically bound on intact platelets. Adrenaline-induced aggregation of platelets in vitro was additionally ascertained. Bmax (maximal binding) and KD (dissociation constant) were significantly lower in endurance-trained athletes (148 fmol per 10(9) platelets, KD = 0.92 nmol) than in the nine nonendurance-trained individuals (284 fmol, KD = 1.79 nmol, P less than 0.01), amounting to 89 receptors per cell (endurance-trained subjects) and 171 (nonendurance-trained subjects). No significant change of receptor density or affinity was observed subsequent to exhaustive exercise in the group of eight endurance-trained individuals. Bmax values and oxygen uptake capacity correlated negatively (r = -0.78, P less than 0.001) and Bmax values and induced platelet aggregation in vitro positively (r = 0.79, P less than 0.001). Data may indicate a reduced sensitivity of platelets in endurance-trained subjects.

Adult↗
PubMed1986

[Local fibrinolytic therapy in thrombotic complications of peritoneovenous shunt].

Since 1981 in the University Hospital of Freiburg 41 patients with ascites have been treated by installation of a peritoneo-venous shunt system. In 9 patients thrombotic complications occurred. Two patients had to undergo a second surgical treatment. Seven patients have been treated by local fibrinolysis. In 6 patients local fibrinolytic therapy was partly or completely successful, in one patient local fibrinolysis was of no therapeutic effect.

Adult↗
PubMed1985

[Spectrum of von Willebrand-Jürgens syndrome. A study on 53 patients].

Von Willebrand-Jürgens syndrome was diagnosed in 53 patients on the basis of bleeding symptoms and blood clotting analytical findings. It was possible to classify the patients into four types using the recommendations of the European Thrombosis Research Organization. Type I, 56%, was most common, 15% belonged to type II, 13% to type III and 16% to type IV. Whereas type I corresponds to the so-called classical von Willebrand-Jürgens syndrome, types II-IV demonstrate the heterogeneity of the disease.

Antigens↗
PubMed1985

[Induced platelet aggregation in patients with coronary heart disease as well as trained and untrained control persons].

Induced in vitro platelet aggregation (adrenaline and collagen) and serum lipid levels were investigated in 21 postinfarction patients, in 11 of these patients subsequent to therapy with 46 +/- 14 mg nifedipine per os daily for one week and in 21 untrained, 16 endurance-trained, and 17 non-endurance-trained healthy male control subjects. Plasma catecholamine levels at rest (patients) and oxygen uptake capacity (control subjects) were determined in subgroups. Mean platelet aggregation was increased in patients (p less than 0.05) and was decreased both in endurance-trained subjects (p less than 0.05) and in the group of 11 patients subsequent to therapy with nifedipine (p less than 0.01), but platelet aggregation was slightly higher in non-endurance-trained individuals. Adrenaline-induced platelet aggregation correlated positively with collagen-induced aggregation (r = 0.72), with LDL-cholesterol fraction (r = 0.51) and negatively with oxygen uptake capacity (r = -0.49). Patients with increased LDL-cholesterol levels also showed increased plasma catecholamine levels (r = 0.49 and r = 0.43). Low aerobic capacity (oxygen uptake capacity), high LDL-cholesterol levels and plasma catecholamine concentrations indicate an increased induced platelet sensitivity in vitro.

Adult↗
PubMed1979

[A variant of the von Willebrand-Jürgens-syndrome with abnormalities of the factor VIII/von Willebrand factor protein (author's transl)].

A family is reported with a variant of von Willebrand's disease. The members of this family showed a qualitative defect of the factor VII/von Willebrand factor protein. The qualitative defect was characterized by an abnormal electrophoretical mobility of factor VIII-related antigen and an abnormal elution pattern as demonstrated by gelfiltration on Sepharose 4 B. Factor VIII-subunits in these patients were found to be normal by polyacrylamidgelelektrophoresis.

Blood Coagulation Factors↗