Biomedical subjects

K Hastie

Publications and source records attributed to K Hastie.

3 recordsLinked to original sources

PubMed1998

Endobrst: simple and safe is best.

Minimal-access treatment for ureteropelvic junction (UPJ) obstruction is becoming increasingly complex. Is there still a place for the simple procedure of balloon dilatation? To examine the symptomatic and renographic results of patients at least 6 months after balloon disruption of an obstructed UPJ, we carried out a prospective audit of outcome as judged by DTPA renograms and clinical follow-up. The procedure has been performed on a total of 21 renal units (20 patients) with follow-up of 6 to 30 months (mean 22 months). Of these, 18 (86%) were asymptomatic at 3 months, although this success rate dropped to 17 (81%) by 6 months. Renographic split function improved in 11 renal units, and excretion improve in 14. Perioperative complications were few and associated with stent insertion. Three of the patients in whom the procedure failed went on to nephrectomy (14%); all had poor renal function (split <20%) at presentation. Although the quoted success rates are lower for endoluminal balloon rupture of stenosis treatment than open pyeloplasty, the former technique has significantly less morbidity. Our nephrectomy rate reflects our less than ideal early patient selection, and our balloon dilation technique is not recommended as a salvage procedure for patients in whom nephrectomy is inevitable. The learning curve is quick to climb, and this is a fundamentally simple procedure with medium-term results that remain encouraging.

Adult↗

PubMed1992

Developmental surface dyslexia and dysgraphia: an orthographic processing impairment.

This study presents a detailed investigation of a young man in his early twenties who has suffered from a severe spelling impairment since childhood, and currently has a spelling age of only 9 years and 2 months. In contrast with the developmental phonological dyslexics reported by Campbell and Butterworth (1985) and Funnell and Davison (1989), his performance on tests of phonological awareness is good. In addition, he can read and spell non-words competently and, unlike normal 9-year-old children, virtually all of his spelling errors are phonologically appropriate. Further analysis of these errors reveals that he has knowledge of many of the different ways in which a given phoneme can be written, and that he uses phoneme-to-grapheme correspondences at the end of a word that are different from those he uses earlier in a word. However, he finds it difficult to spell words that contain uncommon phoneme-to-grapheme correspondences, which is compatible with the view that he has not developed an orthographic spelling lexicon. Although his oral reading of words is prompt and generally accurate, analysis of his lexical decision performance and the way that he defines homophones indicate that he does not have fully specified lexical entries available for reading either. We suggest that he suffers from a general orthographic processing deficit, and relies instead upon the combination of sub-lexical phonology and a lexicon that contains only partial information about the way in which words are spelt. This leads to reasonably competent reading, even of many irregular words, but produces very poor spelling. It is argued that qualitatively different types of developmental dyslexia do genuinely exist, but that reading impairments are likely to be much more pronounced in children who have a phonological rather than an orthographic processing deficit.

Adult↗

PubMed1991

Local and systemic effects of repeated intraperitoneal epirubicin treatment.

The local toxicity, general morbidity and mortality of repeated intraperitoneal administration of epirubicin (0.5 mg/kg in 100 ml isotonic saline) was investigated using a rat model. This dose is equivalent to that which would be used in the human. After six perfusions, the incidence of peritoneal inflammation was similar in the epirubicin group and saline controls. The vesicant properties of the drug were reflected in a significantly higher incidence of peritoneal fibrosis (P = 0.0015) but adhesions were more common in the controls (29%) than in the epirubicin perfused animals (4%). Animals from both groups showed inflammatory collections within the liver. There were no chronic hepatic lesions such as fibrosis/cirrhosis. This may be owing to portal bacteraemia caused by repeated cannulation of the peritoneal cavity. Evidence of microabscess formation in the hepatic parenchyma was observed in both animals. No histologically demonstrable toxicity was observed in the heart or gastrointestinal tract of the animals included in this study. The mortality of the epirubicin treated rats (2/146 perfusions) was similar to that of the saline controls (2/84 perfusions). These findings indicate that repeated intraperitoneal perfusion with epirubicin is not associated with significant toxicity. This anthracycline is therefore suitable for prolonged cyclical intraperitoneal chemotherapy.

Animals↗