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Biomedical subjects

K Hasuo

Publications and source records attributed to K Hasuo.

At least 55 records · Page 3Linked to original sources

Olivary degeneration after cerebellar or brain stem haemorrhage: MRI.

Magnetic resonance (MR) images of seven patients with olivary degeneration caused by cerebellar or brain stem haemorrhages were reviewed. In four patients with cerebellar haemorrhage, old haematomas were identified as being located in the dentate nucleus; the contralateral inferior olivary nuclei were hyperintense on proton-density- and T2-weighted images. In two patients with pontine haemorrhages, the old haematomas were in the tegmentum and the ipsilateral inferior olivary nuclei, which were hyperintense. In one case of midbrain haemorrhage, the inferior olivary nuclei were hyperintense bilaterally. The briefest interval from the ictus to MRI was 2 months. Hypertrophic olivary nuclei were observed only at least 4 months after the ictus. Olivary degeneration after cerebellar or brain stem haemorrhage should not be confused with ischaemic, neoplastic, or other primary pathological conditions of the medulla.

Aged↗

Intracranial adenoid cystic carcinoma mimicking meningioma: report of two cases.

Two cases of intracranial adenoid cystic carcinoma mimicking meningioma are reported. In one, MRI showed not only a homogeneously enhancing extra-axial tumour attached to the dura mater of the posterior cranial fossa, but also surrounding dural enhancement, the "dural tail sign". In the second, CT demonstrated a well-demarcated enhancing extra-axial tumour, indistinguishable from a sphenoid ridge meningioma extending into the orbit. The neuroradiological features of intracranial adenoid cystic carcinoma may thus closely resemble those of meningioma.

Aged↗

Primary progressive versus relapsing remitting multiple sclerosis in Japanese patients: a combined clinical, magnetic resonance imaging and multimodality evoked potential study.

Thirty-five Japanese patients with relapsing remitting multiple sclerosis (RRMS) and 11 Japanese patients with primary progressive MS (PPMS) were compared by a combined clinical, magnetic resonance imaging (MRI) and multimodality evoked potential (MEP) study. Patients with PPMS showed a more common occurrence of gait disturbance as the initial symptoms as well as a more common occurrence of cerebellar symptomatology than did those with RRMS, while spinal cord symptomatology was frequently observed in both conditions. On brain MRI, patients with PPMS had 3 times more lesions than did those with RRMS (P < 0.001, chi 2-test). The percentage of infratentorial lesions was also significantly higher in PPMS than in RRMS on MRI. Moreover, we found a significantly higher frequency of abnormal records in visual, brainstem auditory and somatosensory evoked potentials in PPMS than in RRMS. Interestingly, clinically unexpected abnormalities were significantly more common in PPMS than in RRMS throughout all modalities of MEPs. Thus, in Eastern MS, there exists a distinction between PPMS and RRMS in the MRI and MEP findings as well as in the clinical findings. Our result therefore suggest that there may be two distinct subtypes in MS.

Adult↗

Discrepancy between provocative test and clinical results following endovascular obliteration of spinal arteriovenous malformation.

We report a case of spinal arteriovenous malformation with no signs of neurological deterioration after transarterial embolization, although the results of a provocative test with injection of lidocaine was positive on monitoring of clinical findings and somatosensory-evoked potentials (SEPs). We discussed the possible overestimation by the provocative test, and the limitations of SEP monitoring during endovascular surgery.

Adult↗

Renovascular hypertension caused by lymph node metastasis in a patient with uterine cervical cancer: case report.

Renovascular hypertension was found in a fifty-four-year-old woman who had been diagnosed as having uterine cervical cancer, stage Ib, six months before admission. Renal arteriography showed a stenosis of the right renal artery with a significant increase in renal vein renin level from the ipsilateral kidney. Abdominal computed tomographic scanning showed enlarged lymph nodes in the para-aortic region at the level of the right renal artery, which suggested metastasis of the carcinoma. Metastatic lymph node swellings probably caused compression of the right renal artery.

Female↗

[Akin moyamoya disease in children].

Moyamoya disease is characterized by bilateral involvement of the internal carotid arteries. The etiology of this involvement is unknown. However, we previously reported two pediatric cases of moyamoya disease that progressed from unilateral to bilateral involvement. Some cases of unilateral occlusion in the carotid fork seem to have occurred at an early stage of definite moyamoya disease. In the present study, we examined five pediatric patients showing bilateral and/or unilateral occlusion of the internal carotid artery. In each case, the etiology was known. They included Apert syndrome, radiation therapy for pilocytic astrocytoma, systemic lupus erythematosis, von Recklinghausen disease and Down syndrome. The clinical manifestations, EEG, CT, MRI, PET, and angiographic findings in these patients were presented in comparison with those of definite moyamoya disease. This comparison led us to suggest that definite moyamoya disease might be included in these cases, and we emphasize the importance of precise examination in each case.

Acrocephalosyndactylia↗

[Two cases of huge hepatic hemangioma].

We have experienced two cases of huge hepatic hemangioma. Case 1 was a 51-year-old man complaining of abdominal fullness and was shown low density area in the right hepatic lobe by abdominal computed tomography. He was treated with segmentectomy of the right hepatic lobe. The resected specimen was histologically diagnosed as cavernous hemangioma. Case 2 was a 61-year-old man who showed no symptom and was shown 10 x 6.5 cm hemangioma by abdominal ultrasonography. He have been untreated. For 10 years, 29 cases of huge hepatic hemangioma, including our two cases have been reported in Japan. The female to male ratio is 5:1. The incidence of huge hepatic hemangioma was frequent in the fifth and sixth decades of life. The majority of patients complained of palpable abdominal mass and abdominal pain. The dominant site of huge hepatic hemangioma was the anatomical right hepatic lobe.

Hemangioma, Cavernous↗

[MR imaging of pericallosal lipomas].

Eight cases of pericallosal lipomas were studied by MR imaging at 1.5 Tesla. All were located around the splenium of the corpus callosum, and were classified as the curvilinear type. Corpus callosal abnormalities were detected in the six of these eight cases, and included two cases of short corpus callosum and four of thin splenium. The larger lipomas tended to have greater abnormalities of the corpus callosum. T1-weighted sagittal images were the most useful pulse sequences for diagnosing pericallosal lipomas and corpus callosal abnormalities. On review of the literature we found that the curvilinear type of pericallosal lipoma is more frequently observed by MR imaging than the tubulonodular type.

Adolescent↗

[MR imaging of stereotactic thalamotomy using radiofrequency methods].

Sixty-eight stereotactic radiofrequency (rf) thalamic lesions in 57 patients with movement disorders were evaluated by magnetic resonance (MR) imaging. Postoperative periods ranged from 5 days to 4 years and 9 months. All 68 rf lesions were clearly detected on T2-weighted images (T2WI). Changes in signal intensity on T2WI were classified into five patterns, as follows: Pattern I: lesions with three concentric zones consisting of an inner hypointense, middle hyperintense and outer hypointense zone (31 lesions); Pattern II: lesions consisting of an inner hypointense and outer hyperintense zone (4 lesions); Pattern III: lesions consisting of an inner hyperintense and outer hypointense zone (27 lesion); Pattern IV: lesions of a hyperintense area alone (2 lesions); Pattern V: lesions of a hypointense area alone (4 lesions). The outer hypointense rim in Patterns I and III is thought to represent hemosiderin deposition. The abnormal signal intensity on T2WI caused by rf ranged from 2 to 12 mm in diameter, and lesions in the late phase were smaller than lesions in the early phase.

Adolescent↗

[MR imaging of intraocular lesions--a comparison with CT].

Thirty-two intraocular lesions were studied with magnetic resonance (MR) imaging and computed tomography (CT). These lesions included retinoblastoma (n = 11), uveal melanoma (n = 6), metastatic choroidal tumor (n = 3), choroidal hemangioma (n = 2), retinochoroiditis (n = 6) and Coats' disease (n = 4). MR imaging was superior to CT in the depiction of intraocular masses and retinal detachment. Gd-DTPA enhanced MR imaging was more useful than contrast enhanced CT in evaluating the contrast enhancement of intraocular tumors. Differential diagnosis of intraocular tumors was difficult with both MR imaging and CT. Intratumoral calcification was noticed on CT in nine cases of retinoblastoma. It was concluded that MR imaging, including contrast enhancement study, is more useful than CT in the evaluation of intraocular lesions, except for calcification, and contrast enhanced CT may be unnecessary in the diagnosis of intraocular lesions.

Eye Diseases↗

MR imaging and angiography of cerebral venous angiomas associated with brain tumors.

MR study of 6 patients with concurrent venous angioma and brain tumor revealed that in 2 of the 6 cases, the draining vein of the venous angioma was located near to the tumor and was displaced by the tumor. Two of the 6 venous angiomas were too small to visualize prior to contrast enhancement, but could be detected following administration of Gd-DTPA. Angiography was required for definitive diagnosis of the venous angiomas. When a venous angioma is suspected or is detected incidentally, especially when very near a brain tumor, angiography should be considered before performing surgery to avoid surgical complications. Otherwise, ligation of the vein draining the venous angioma may lead to venous infarction.

Adolescent↗

Positron emission tomography (PET) in "pure akinesia".

Positron emission tomography (PET) studies on regional cerebral glucose metabolism and [18F]fluorodopa uptake were performed on 3 patients with "pure akinesia without rigidity and tremors", 3 progressive supranuclear palsy (PSP) patients, and 5 patients with Parkinson's disease. The "pure akinesia" and PSP patients showed a marked decrease in glucose metabolism in the frontal cortex and striatum, and a decreased uptake of [18F]fluorodopa in the striatum. While the Parkinson's disease patients had a decreased uptake of [18F]fluorodopa in the striatum but no abnormality in the glucose metabolism. Magnetic resonance imaging (MRI) showed atrophy of the pretectum and dorsal pons in "pure akinesia" and PSP patients, but there was no such abnormality in the Parkinson's disease patients. As described above, patients with "pure akinesia" and PSP patients revealed similar findings on PET and MRI studies, while Parkinson's disease patients showed substantially different results.

Adult↗

Hypertrophic cranial pachymeningitis due to Aspergillus flavus.

A 59-year-old woman suffered from occipital headache and bilateral cranial nerve VII, VIII, IX, X, XI and right XII deficit after developing otitis media. Magnetic resonance imaging (MRI) showed a thickening of the dura mater which was enhanced by gadolinium-DTPA (Gd). Aspergillus flavus was identified from the culture of otorrhea. She was treated with miconazole, flucytosin and fluconazole, which resulted in an improvement of the clinical symptoms and a thinning of the Gd-enhanced lesions on MRI. This is the first case of hypertrophic cranial pachymeningitis caused by Asp. flavus infection.

Aspergillosis↗

Growth retardation in childhood leukemia and lymphoma. Special reference to patients with CNS relapse.

We studied the growth of 89 patients who were long-term survivors of childhood leukemia and lymphoma. Eight patients with CNS relapse had a greater decrease in height standard deviation score (SDS) after the relapse than 81 patients without CNS relapse (p less than 0.0001). Two patients who received cranial irradiation when they were younger than 2 years of age demonstrated a marked decrease in height SDS more than 3.0 SD. Five patients appeared to have a decline in height SDS before their CNS relapse. There were no apparent changes in the weight of patients with or without CNS relapse. In endocrine studies, all eight patients with CNS relapse failed to show the normal growth hormone (GH) response to arginine, GH-releasing factor, and glucagon-propranolol tests, while spontaneous GH secretion during sleep was normal. Magnetic resonance imaging (MRI) revealed small pituitary glands in seven patients with CNS relapse. These findings suggest that in leukemia and lymphoma patients with CNS relapse, GH secretion is impaired at the hypothalamic level, resulting in a secondary atrophy of the pituitary gland. The MRI together with selected endocrinologic tests may help to clarify the mechanism of growth impairment in such patients. A decline in height SDS in each patient may be a useful marker for predicting a CNS relapse in a child with leukemia or lymphoma.

Adolescent↗

Surgical treatment of moyamoya disease in pediatric patients--comparison between the results of indirect and direct revascularization procedures.

Either encephaloduroarteriosynangiosis (EDAS) or superficial temporal artery to middle cerebral artery (STA-MCA) anastomosis combined with encephalomyosynangiosis (EMS) has been performed on most of the children with moyamoya disease in our department. EDAS alone was done in the parietal region of 13 sides in 10 patients, and STA-MCA anastomosis with EMS in the parietal region was done on 7 sides in 6 patients. The surgical results of these two different procedures were then compared. Postoperative collateral formation was observed on external carotid angiograms, and the improvement of clinical symptoms was monitored for 1 year after the bypass procedure. STA-MCA anastomosis with EMS was found to be superior to EDAS in both the development of collateral circulation (P less than 0.05) and postoperative clinical improvement (P less than 0.01). EDAS can be done easily and safely on small children with moyamoya disease, but STA-MCA anastomosis with EMS is considered to be more appropriate, whenever possible.

Cerebral Angiography↗

Microsurgical and angiographic analysis of anterior communicating artery aneurysms with associated anomalies.

A direct operation was performed on 110 patients with an aneurysm of the anterior communicating artery (ACoA). During the surgery, in 52% of the cases, the neck of the aneurysm was found at the junction of the A-1 segment and ACoA and they presented with a hypoplastic contralateral A-1 segment. Associated ACoA anomalies were seen in 13 (12%) of the 110 cases. The most common anomaly was duplication of the ACoA, found in 11 cases (10%). In 2 other cases triplicate ACoA was found. Preoperative bilateral carotid angiograms were reviewed and duplication of the ACoA associated with the aneurysms able to be pointed out on angiograms in 4 cases, retrospectively. The anatomical and radiological aspects of aneurysms with associated anomalies are also discussed.

Adult↗

[MR imaging in paranasal and intracranial aspergillosis].

The MR findings in three patients with paranasal and intracranial aspergillosis were analyzed. Two patients had sphenoid sinus aspergillosis with mucocele, and one had aspergillosis in the maxillary sinus and pachymeningitis in the posterior fossa. In all patients with aspergillosis of the paranasal sinuses, a markedly hypointense area was present within the lesion on T2-weighted images. In the patient with pachymeningitis, contrast-enhanced MR images clearly demonstrated the extent of the lesion.

Aspergillosis↗