PubMed Health⌕ Search

Biomedical subjects

K Hatsuse

Publications and source records attributed to K Hatsuse.

26 records · Page 2Linked to original sources
PubMed1983

[Effect of solcoseryl and combined therapy of solcoseryl and FT-207 for mice bearing meth-A tumor].

The effects of a combined chemotherapy of solcoseryl and FT-207 on tumor growth, delayed hypersensitivity and cell population of the spleen were studied using inbred BALB/c mice. Meth-A tumor cells (2 X 10(6] were inoculated into the back of 5 to 6 week old BALB/c male mouse. Animals were divided into three groups: Solcoseryl group, in which 0.04 mg of solcoseryl was injected intravenously three times before inoculation and four times after inoculation; Combined group, in which 1.2 mg of FT-207 and 0.04 mg of solcoseryl were injected intravenously four times after inoculation; FT-207 group, in which 1.2 mg of FT-207 was injected four times after inoculation, with out solcoseryl administration. Following results were obtained: Solcoseryl group showed enhanced immunity and tumor suppression; Decreased immunity due to FT-207 was recovered by administration of solcoseryl but no tumor suppression was observed and, Decreased T-cell population of spleen due to FT-207 was recovered by administration of solcoseryl. These facts suggested that solcoseryl was useful because of making recovery possible from decreased immunity due to chemotherapy.

Actihaemyl↗
PubMed1983

[Case of breast cancer associated with Recklinghausen's disease].

Malignant epithelial tumors associated with Recklinghausen disease are very rare. A 32-year-old female with Recklinghausen disease was admitted to our hospital complaining of a 5 X 4 cm left breast mass. A malignant tumor of the breast was diagnosed by mammography, echography and clinical features. Radical mastectomy was performed and pathological examination showed papillotubular adenocarcinoma. Three cases of breast cancer associated with Recklinghausen disease reported in the Japanese literature were reviewed.

Adenocarcinoma↗
PubMed1983

[Case of gastrin-producing carcinoid, adenocarcinoma and xanthoma of the stomach].

A rare case with gastrin-producing carcinoid, adenocarcinoma and xanthoma of the stomach is presented. A 69-year-old male underwent total gastrectomy with splenectomy and distal pancreatectomy. The histological type of the carcinoid was poorly differentiated (type D), and argyrophil cell carcinoma. Immunoperoxidase staining of the carcinoid was positive for gastrin and negative for glucagon, somatostatin or insulin. The histological findings of the carcinoma were tub 2, medullary, INF alpha, se, ly 2, v 1, ow(-), aw(-), n 1. Histologically, the xanthoma consisted of foamy macrophages accumulated in the lamina propria.

Adenocarcinoma↗
PubMedDate not supplied

Influence of liver cirrhosis on pseudolesions in liver at CT during arterial portography.

PURPOSE: Pseudolesions are sometimes seen around the falciform ligament, around the gallbladder, or at the posterior edge of the medical segment on CT during arterial portography. The purpose of this study was to investigate the influence of liver cirrhosis on these pseudolesions. METHOD: The basis of this study was 33 patients with liver cirrhosis or hepatitis (group A) and 43 with neither (group B). The standard for diagnosis was surgical findings. We investigated whether there was a difference in the frequency of each pseudolesion between groups A and B. When tumors were seen in each location, they were excluded from statistical analysis. RESULTS: Pseudolesion around the falciform ligament was seen in none of 32 patients in group A and in 18 of 40 in group B (4 cases were excluded), around the gallbladder in 14 of 30 in group A and 16 of 42 in group B (4 cases were excluded), and at the posterior edge of the medial segment in 13 of 33 in group A and 16 of 42 in group B (1 case was excluded). There was a statistically significant difference in the frequency of pseudolesion around the falciform ligament (p < 0.001, Fisher test), but not around the gallbladder or posterior edge of the medial segment. CONCLUSION: Liver cirrhosis decreases the frequency of pseudolesions around the falciform ligament, but not around the gallbladder or posterior edge of the medial segment.

Adult↗
PubMedDate not supplied

Systemic phaeohyphomycosis caused by Exophiala dermatitidis.

We report a case of systemic phaeohyphomycosis due to Exophiala dermatitidis in a 24-year-old man. At the age of 17, the patient had noticed cervical swellings. On palpation at his initial examination, more than a dozen firm lymph nodes between 1 and 5 cm in diameter were found on both sides of the neck and in both axillae. Examination of biopsy specimens of lymph nodes revealed pale brown hyphae in granulomatous lesions and Exophiala dermatitidis was isolated from mycological cultures of the local tissues. The clinical course was marked by an episode of jaundice six months later, and surgery disclosed a fist-sized inflammatory mass in the region of the head of the pancreas and the duodenum. The patient was treated by providing external biliary drainage and by the administration of antifungal agents, but two years later complained of diplopia and a slight heaviness in the head. Computed tomographic scans were made of the head, revealing multiple plum-sized masses in the brain. The patient died a year later. In Japan, 10 cases of systemic infection by this organism (including the present one) have been reported, all in patients of up to 30 years of age, with lesions appearing in the brain, lung, liver, digestive organs and lymph nodes. The prognosis is grave.

Adult↗
PubMedDate not supplied

Enhanced expression of translation factor mRNAs in hepatocellular carcinoma.

Several studies have demonstrated elevated expression of translation factor mRNAs in malignant tissues. In this study, using primary human hepatocellular carcinoma (HCC) tissues, we examined gene expression of translation factors, including 2 eukaryotic initiation factors (eIFs-4A1, -4E), 4 elongation factors (eEFs-1 alpha, -1 gamma, -1 delta, and -2) and 10 ribosomal proteins (Rps P1, P2, S10, L35, L5, L39, L9, L6, S3a and S17), whose mRNA expression has never been examined in HCC. Our results demonstrated that all the mRNAs examined were up-regulated in HCC tissues. Among 7 HCC tissues of different histological grades, the expression of these mRNAs remained at basal levels in a well to moderately differentiated (W/M-) HCC, was coordinately up-regulated in moderately differentiated (M-) HCCs. In moderately to poorly differentiated (M/P-) HCCs, the expression of eEFs-1 gamma, -1 delta, -2, Rps P0 and L9 mRNAs was further up-regulated along with the histological grading. These results therefore suggest that coordination and specific activation of translation factor genes might be involved in the process of liver carcinogenesis.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Postsurgical intrahepatic portal thromboembolism: a possible cause of perfusion defects on CT during arterial portography.

OBJECTIVE: Our goal was to investigate unexplained nontumorous perfusion defects on CT arterial portography (CTAP). MATERIALS AND METHODS: The CTAP images of 35 patients who underwent partial hepatectomy or open biopsy were analyzed. Hepatic tumors consisted of hepatocellular carcinoma (n = 18) and colorectal carcinoma metastases (n = 17). Nontumorous perfusion defects were categorized into those previously explained and those unexplained. We investigated unexplained ones and their relationship with the underlying conditions. RESULTS: Eight unexplained nontumorous perfusion defects were found in four patients with colorectal metastases. Statistical analysis showed that the defects occurred with significantly higher incidence in patients with colorectal metastases than in those with hepatocellular carcinoma (p = 0.046, Fisher test). All four patients with defects underwent CTAP within 1 month after colorectal surgery. A significant difference was seen in the distribution of surgery-CTAP time intervals between those patients with and those without defects (p < 0.05, Wilcoxon-Mann-Whitney test). Intrahepatic portal thrombi were pathologically proven in one of the four patients. CONCLUSION: Unexplained nontumorous hepatic perfusion defects may represent postsurgical portal thromboemboli.

Adult↗