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Biomedical subjects

K Hayashibe

Publications and source records attributed to K Hayashibe.

26 records · Page 2Linked to original sources
PubMed1988

Japanese monkeys' cardiac responses to visual depth.

The present study examined the heart-rate changes which occurred in the visual-depth situation of Japanese monkeys (Macaca fuscata). Four animals were tested over the first four weeks of age in the visual pitfall designed as a modification of the visual cliff. The infant monkeys showed heart-rate reduction in the depth condition. This reduction was observed from the first week and became remarkable at the third week. There were no differences in heart-rate change between monocular and binocular vision. These findings suggest that the Japanese monkey can discriminate visual depth shortly after birth and that the heart-rate reduction depends upon the fear of visual depth, not upon the novelty of the situation.

Animals↗
PubMed1988

Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin.

White forelock and hypomelanotic macules of piebaldism have been revealed to have almost regularly distributed, dopa-positive melanocytes, though with lower density than normal, on separated epidermis despite previous reports describing few or no melanocytes in piebald spots. The melanocytes observed in piebald hypomelanotic spots seem to be classified into the following two types: (1) strongly dopa-positive and markedly hyperdendritic large cell type and (2) moderately dopa-positive and slightly hyperdendritic, oversized cell type. The former are primarily seen in hypomelanotic lesions, while the latter are seen in transitional lesions. The above difference seems to be associated with compensatory melanogenic function of melanocytes in vivo. Moreover, we have induced new hyperpigmented spots in hypomelanotic lesions, with the exception of white forelock, following therapy with oral methoxsalen plus ultraviolet A light.

Catechol Oxidase↗
PubMed1986

Melanosomal antigenic expression on the cell surface and intracellular subunits within melanogenic compartments of pigment cells: analysis by antimelanosome-associated monoclonal antibody.

Antimelanosome-associated monoclonal antibody has recognized the common antigenic determinant of melanosomes and cell surface of pigment cells, and it is suggested that melanosomes play a significant role as an antigen in progressive depigmentary disorders, in which melanocytes are selectively altered and disappear presumably by auto-antibodies in vivo. Mouse myeloma cells were fused with spleen cells from BALB/c mice immunized with a melanosomal fraction separated from human melanotic melanoma cells (Mm-1-JCK). The monoclonal antibody (MoAb) A4F11 has been found to react with premelanosomes, melanosomes, and probably with Golgi-associated endoplasmic reticulum lysosomes, but not with mitochondria, nuclei, and cytosol from human melanoma cells, by immunoelectron microscopy using the saponin permeation method, which was carried out together with indirect radioimmunoassay and quantitative absorption assay. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting using melanosome preparations have revealed the antigen(s) reactive with the MoAb A4F11 in 3 bands corresponding to Mr 50,000, 18,000, and 17,000. Cell binding assay has shown the reactivity of the MoAb A4F11 with the cell surface of human normal melanocytes and melanoma cells, but not with other mammalian melanoma cells or with human nonpigment cells examined. Indirect immunofluorescence on cultured cells and frozen sections has revealed distinct granular reactivity not only with human melanotic melanoma, but also with junctional and intradermal nevi, cultured malignant blue nevus cells, as well as normal melanocytes. The above evidence has indicated the presence of an antigenic determinant common to the intracellular melanogenic compartments and to the cell surface of human pigment cells, regardless of their oncogenic differentiation status.

Adult↗
PubMed1985

Solar urticaria. Further studies on the role of inhibition spectra.

A 27-year-old woman exhibited an urticaria only to monochromatic light in the range from 400 to 525 nm, but not to polychromatic light longer than 360-nm ultraviolet (UV) and visible light. An urticarial response induced by 475-nm monochromatic light was completely inhibited by preirradiation, simultaneous irradiation, and postirradiation with light having wave bands longer than 650 nm. Two other patients with sunlight-induced solar urticaria, who had an erythema-and-wheal reaction during and after exposure to sunlight, had no suppressive wave bands in either the UV or visible-light range. These observations strongly indicate an important role for inhibition wave bands in the development of light-induced immediate erythema and urticaria. In some cases of solar urticaria, preirradiation and postirradiation with longer visible light wavelengths could be useful in preventing the development of urticaria.

Adolescent↗