Biomedical subjects

K Henle

Publications and source records attributed to K Henle.

4 recordsLinked to original sources

PubMed2001

The impact of a cancer education program on the knowledge base of participating students.

BACKGROUND: Partners in Research is a ten-week summer elective designed to provide cancer-related educational activities. This study was undertaken to evaluate the impact of the program on the general cancer knowledge of medical students, pharmacy students, and undergraduate biology majors. METHODS: The 24 students enrolled in 1999 were evaluated using a pretest and post-test with 75 multiple-choice questions. RESULTS: The mean test score increased significantly from 46.6% to 53.0% (p = 0.001). Improvements were significant for general cancer knowledge and three specific disease categories (breast, gastrointestinal, and skin cancers). CONCLUSIONS: The results indicate that the program does increase the cancer-related knowledge of students.

Clinical Competence↗

PubMed1995

[Laparoscopy-assisted colon surgery--overview and personal experiences with 64 patients].

The number of laparoscopic or laparoscopic-assisted operations in abdominal surgery constantly increases. 64 patients between February 1992 and November 1993 underwent a laparoscopic assisted colorectal procedure. In 5 cases laparotomy was necessary. There were only 4 complications: one subileus treated conservatively and one peritoneal abscess was drained successfully under sonographic guidance; furthermore there were a postoperative pneumonia and a prolapse of the greater omentum in the area pierced by a 10 mm-trocar. The oncologic criteria for the resection of malignant tumours can be fulfilled in laparoscopic surgery. Our first experiences indicate that the advantages for the patient in laparoscopic procedures of the colon/rectum are the same as have been reported in laparoscopic cholecystectomy.

Aged↗

PubMed1994

A numerical study of rapid heating for high temperature radio frequency hyperthermia.

Hyperthermia is a promising adjuvant cancer treatment modality. However, unresolved engineering problems with the production and regulation of temperature distributions within tissues in vivo have frustrated repeated efforts to implement clinical hyperthermia protocols. A major technical problem with hyperthermia production in vivo is the cooling effect caused by circulating blood in larger vessels. Larger blood vessels, when located in heated tumors, can prevent achievement of sufficiently high temperatures, resulting in loss of therapeutic effect. One possible way of circumventing this problem is the delivery of a critical heat dose during a short-term, high-temperature treatment episode to minimize cooling from blood flow. We investigated the concept of such rapid, high-temperature heating of tissue in a two-dimensional finite element numerical model. The model demonstrates the feasibility of interstitial radiofrequency delivery of a therapeutic heat dose, equivalent to 30 min at 43 degrees C, to a 1 cm3 tumor during a 60-s period. The model assumes circulation of cooling fluid through hollow electrodes. A post processor has been designed to display a 3-D image of the temperature distribution, electric field, and thermal dose delivered to a unit volume within the heated tissue.

Blood Circulation↗

PubMed1985

[D(-)Lactic acid--a metabolism problem].

The metabolization of D-lactate was examined in volunteers by means of renal excretion after intake of DL-lactate, and in rats as well as in rat liver in vitro by the oxidation rate of 14C-D-lactate to 14CO2. In five volunteers after intake of DL-lactate containing 1.60 to 6.5 mmol D-lactate per kg 0.75 (equiv. to 50-200 mg/kg) an average of 1.2-2.2 percent of the dose was eliminated in urine. The exponential decline of renal elimination during the first 15 hours after intake and the total excretion time up to 24 hours (and possibly more) suggested a quite slow rate of metabolism. Following intraperitoneal injection of 2.0 and 4.2 mmol per kg 0.75 in rats (equiv. to 62 and 131 mg per kg in man) the oxidation rate of D-lactate vs. L-lactate was significantly and strongly reduced. After intragastral dosage of DL-lactate containing 4.2 to 12.8 mmol D-lactate per kg 0.75 an average of 0.9 and 2.4 percent were excreted in urine as D-lactate and as metabolites. Even after the lowest dose D-lactate oxidation to CO2 extended far beyond 8 hours. Higher doses decreased the rate of D-lactate oxidation. In tissue samples of rat liver in vitro oxalate, L-lactate and pyruvate inhibited the oxidation of D-lactate. L-lactate in a physiological concentration was sufficient to effect an inhibition of 20 percent. A significant increase of D-lactate oxidation with increasing body weight and a significantly higher oxidation of D-lactate in conventionals vs. germ-free rats indicated the influences of age and gastro-intestinal flora on D-lactate metabolism. From these results it is concluded that D-lactic acid is only slowly metabolized if the concentration of one or other of the lactate isomers is elevated.

Adult↗