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K Hensen

Publications and source records attributed to K Hensen.

8 recordsLinked to original sources
PubMed2000

The addition-reaction product of 1,1,1,4,4,4-hexachloro-1, 4-disilabutane with N-methylimidazole

The product of the addition reaction of 1,1,1,4,4,4-hexachloro-1, 4-disilabutane with N-methylimidazole is &mgr;-ethylene-C(1):C(2)-bis[dichlorotris(1-methylimidazole-N(3))sili con(IV)] dichloride, C(26)H(40)Cl(4)N(12)Si(2)(2+).2Cl(-). Two of the six Cl atoms are replaced by aromatic nitrogen bases and the coordination sphere of silicon is extended from four to six. The molecule is located on a crystallographic centre of inversion. The environment around the Si atom can be described as a slightly distorted octahedron with the Cl atoms occupying axial positions and the three N-methylimidazole ligands and the ethylene bridge in the equatorial plane.

Journal Article↗
PubMed2000

Tetrabromo(2,6-dimethylpyridine-N)titanium(IV), a twinned crystal structure

The reaction of 2,6-dimethylpyridine with TiBr(4) affords the title compound, [TiBr(4)(C(7)H(9)N)], which is the first example of a neutral TiBr(4)L complex (L is a singly bonded ligand). The environment around the Ti atom can be described as a somewhat distorted trigonal bipyramid, with the nitrogen base occupying an equatorial position. The crystal was a non-merohedral twin.

Journal Article↗
PubMed1998

Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.

We have isolated and characterized two novel cDNAs encoding C2H2 zinc finger proteins showing high sequence homology to PLAG1, a protein ectopically activated by promoter swapping or promoter substitution in pleomorphic adenomas with chromosomal abnormalities at chromosome 8q12. PLAG1 and the two new PLAG1 family members (PLAGL1 and PLAGL2) constitute a novel subfamily of zinc finger proteins that recognize DNA and/or RNA. To examine the potential of the three human proteins to modulate transcription, we constructed several PLAG/GAL4 DNA binding domain fusion proteins and measured their ability to activate transcription of a reporter gene construct in different mammalian cell lines and in yeast. Although the carboxyl-terminal part of PLAGL1 shows strong overall transcriptional activity in mesenchymal (COS-1) and epithelial cells (293), both PLAG1 and PLAGL2 transactivate in mesenchymal cells only if depleted from a repressing region. This effect is less profound in epithelial cells. These data suggest that the activation in pleomorphic adenomas of PLAG1 most likely results in uncontrolled activation of downstream target genes.

Amino Acid Sequence↗