[Studies on the factors contributing to uremic dyslipoproteinemia].
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Biomedical subjects
Publications and source records attributed to K Hesaka.
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To analyze left atrial (LA) pump function, aortic root echocardiograms and LA pressure (P) by a Millar 's catheter tip manometer were recorded simultaneously in 26 patients (pts) in regular sinus rhythm [six normal subjects (C), three with angina pectoris (AP), eight with old myocardial infarction (MI), three with congestive cardiomyopathy (CCM), three with hypertension (HT), one with hypertrophic cardiomyopathy (HCM), one with mitral regurgitation and mild stenosis (MRs), and one with mitral regurgitation (MR)]. The pressure-dimension curve of the LA composed of two loops; an A-loop (pump function of the LA) and a V-loop. The following parameters were measured: Da = LA dimension at the beginning of the active atrial shortening, S-A-loop = the area of the A-loop, mean V = mean LA velocity of fractional fiber shortening, and peak T = maximum (LAP X LAD) during active atrial shortening phase. The S-A-loop was directly proportional to Da (r = 0.62, p less than 0.001) and the mean V was inversely correlated with the peak T (r = -0.76, p less than 0.001). This indicated that Starling's mechanism was operative and force-velocity relation exited in the LA. In HT, Da, the S-A-loop, the ratio of the S-A-loop to Da, and the ratio of mean V to peak T tended to be larger than those in other pts groups. Thus, the present results suggested that LA pump function was augmented in HT, probably due not only to Starling's effect but also to enhanced inotropic state of the LA.
We developed a new echocardiographic approach to detect the interatrial septum (IAS) by tilting a transducer leftward, cephalad and backward from the right subcostal area. This technique could allow us to visualize the IAS moving perpendicularly to the ultrasonic beam. In normal subjects the IAS showed a small posterior deflection moving toward the left atrium due to atrial contraction following the P wave of the electrocardiogram. Following the onset of ventricular ejection the IAS rapidly moved anteriorly. During diastole the IAS showed an initial rapid posterior displacement and then a more gradual slope, reflecting rapid and slow filling phases, respectively. The magnitude and configuration of IAS motion showed variations dependent on atrial conditions of cardiac diseases. In atrial fibrillation there were f waves on the IAS echogram and in mitral stenosis a septal notch was recorded at the timing of a mitral opening snap. In mitral valve prolapse there was also a midsystolic notch of the IAS echogram almost coincident in time with the onset of a late systolic murmur. On the other hand, the IAS revealed a systolic increased excursion or paradoxical motion in mitral or tricuspid regurgitation, respectively. In hypertension and myocardial infarction the atrial kick of the IAS echogram showed an exaggerated excursion. In 125 out of the consecutive 150 cases (83.3%) we could record satisfactory IAS echograms by this new approach.
To evaluate the active systolic function of both atria in sick sinus syndrome (SSS), conventional and esophageal echocardiograms were recorded in 22 normal subjects (Normal), 5 patients (pts) with sinus bradycardia (Group I), 9 with sinoatrial block or sinus arrest (Group II), 10 with bradycardia-tachycardia syndrome (BTS, Group III) and 6 with transient atrial fibrillation (Group IV). Two pts in Group II and 8 in Group III had a history of syncope. Atrial filling fraction obtained by the left ventricular echogram (AFF by LV echo) and posterior wall excursion of the aorta during atrial contraction (Ea) were determined by the conventional echocardiogram. The excursion of the interatrial septum during atrial contraction (Eb) and the dimensional shortening of the right atrium during atrial contraction (Ec) were determined by the esophageal echocardiogram. Results were as follows: AFF was almost the same in Normal, and Group I, II and IV, but it was significantly lower in Group III. AFF was also decreased in 2 pts in Group II who had a history of syncope. Both Ea and Eb in Group III were significantly lower than those in the other groups. Ec was not significantly different among all groups, although one patient in Group III had markedly decreased Ec. There was a significant correlation between Ea and AFF (r = 0.638, p less than 0.001). We conclude that in a number of cases with SSS, especially BTS, left atrial active contraction is significantly impaired in addition to the electrophysiological abnormality.
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