Biomedical subjects
K Hinke
Publications and source records attributed to K Hinke.
Anti-cholinesterase agents uptake during cultivation of greenhouse flowers.
The cholinesterase (ChE) activities were measured in-season and out-season in a total of 204 greenhouse workers and 360 non-exposed controls. No seasonal ChE variation were observed in the controls, whereas an in-season depression was seen in the workers, indicating an uptake of anti-cholinesterase agents during cultivation of greenhouse flowers in the intervals between sprayings (p = 0.0001). The anti-ChE agents applied seem to persist in the greenhouses and cause continued subtoxic uptake for weeks since last application. Wearing of protective gloves did not prevent the uptake. Thus, chronic percutaneous and oral uptake occurs as a result of cultivation of greenhouse flowers.
Indoor application of anti-cholinesterase agents and the influence of personal protection on uptake.
The relationship between plasma-cholinesterase (ChE) measures and the uptake of anti-cholinesterase agents among 125 greenhouse sprayers in connection with normal working conditions were studied. An in-season ChE depression was observed indicating absorption of organophosphate (OP) or carbamate insecticides (p = 0.0001). The in-season enzyme depression among sprayers, exclusively exposed to carbamates (p = 0.06), probably reflects chronic percutaneous or oral uptake in the intervals between spraying by cultivating pretreated flowers. The frequency of applications (p = 0.03) and the wearing of protective clothings (p = 0.02) seems to be working habits, which significantly influenced the ChE activities, whereas gloves or face mask did not (p greater than 0.05). Especially, the wearing of whole-body protective clothing (p = 0.008) are of particular value in preventing percutaneous absorption.
Chronic subclinical intake of dietary anticholinesterase agents during the spraying season.
The dietary intake of anticholinesterase (anti-ChE) agents was estimated in 331 schoolteachers during the spraying season. Summer plasma-cholinesterase (ChE) activity was compared with the baseline value obtained during winter. Intraindividual plasma-ChE activity varied independently of factors such as drugs, non-malignant diseases, alcohol and smoking. A depressed mean plasma-ChE, indicating an intake of anti-ChE agents (P = 0.04), was observed in individuals who consumed exclusively agriculturally-grown fruits and vegetables without an additional intake of unsprayed, home-grown products. It remains to be determined whether a subclinical but chronic intake of anti-ChE agents in the diet can be hazardous to humans.
Palliative endobronchial tumor reduction by laser therapy. Procedure--immediate results--long-term results.
Over a period of 3 years, 224 laser treatments were performed on 105 patients. 84% were carried out under local anesthesia and 16% under general anesthesia. A neodymium-YAG laser (MBB-AT) was used. In 74% of the cases complete or partial tumor removal was possible. 72% of the successfully recanalized stenoses were still open after 4-6 months. In 19% of the cases low-grade complications occurred. The mortality was below 1%. The chief indications for endobronchial laser treatment are exophytic endobronchial tumors in the area of the trachea and primary bronchi. Endobronchial laser coagulation is indicated when surgery is no longer possible. It serves primarily to improve ventilation and bronchial drainage and in particular to prevent retention pneumonia.