Biomedical subjects
Publications and source records attributed to K Holzegel.
Following gold therapy in a patient with rheumatoid arthritis a transient rash and permanent nail dystrophy resulted. Following onycholysis of several finger and toe nails the nails showed permanent alterations in form of longitudinal streaks and were extremely thin, soft, and fragile. Intracutaneous tests with the commercial gold solution revealed an allergic reaction of the delayed type.
Explore the source record for details and available documents.
Contact-allergy eczemas due to dichloropropiophenone. Following an exposition to p-beta-dichloropropiophenone (DCP) of less than one year nine skilled chemical plant workers were taken ill with an eczema from contact allergy, particularly badly seizing their faces, necks, hands and forearms. In all workers in question has been recognized a job connected skin disease with bodily impairment of 20 to 30%. The test concentration of DCP was determined at 0.01% (testing vehicle: oil). Nonexposed persons showed response only at 0.5% DCP concentration (50 times higher percentage!) by falling sick of an uncomplicated irritation erythema, strickly localized. With regard to the almost obligatory tendency towards sensitization there must be strict observation of the stringent measures of a labour protection, and moreover, in the future there should be established a closed system of automatic control.
Explore the source record for details and available documents.
The events during a sclerosant injection were controlled radiographically. Vistarine forte containing 21.5% of total iodine makes the distribution of fluid clearly visible, both opacifying and sclerosing. 1 ml of air precedes the injection of 0.5 ml of sclerosant. This has shown that the "air-block", as found in the syringe, is not exactly a cushion of air separating the vessel wall from contact with the circulating blood. The air is distributed like a collar of pearls along the vein walls. These bubbles of air remain visible for a long time in the varicose convultions and this tend to hinder contact between the sclerosant and the intima of the varicose vein. As the slides show, it is a well demarcated segment of the varicose vein which comes into effective contact with the sclerosant. It is precisely this segment which subsequently becomes sclerosed. The sclerosant seeks a centripetal pathway in all positions, lying standing and sitting. The therapeutic effect is the same, and is independent of the position of the patient at the time of the injection of sclerosant.