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Biomedical subjects

K Hruska

Publications and source records attributed to K Hruska.

6 recordsLinked to original sources
PubMed1979

[Effect of chorionic gonadotropin administration on the concentration of testosterone in the blood of boars].

In intact boars, intravenous administration of 100 to 6000 I. U. chorionic gonadotropin elicited a pronounced rise in the plasma level of testosterone, depending on the time interval from the administration of chorionic gonadotropin and on the size of the administered dose. In the blood of castrated boars such an application of choronic gonadotropin did not influence the concentration of testosterone. It was inferred that the rise in the levels of blood testosterone in boars after administration of chorionic gonadotropin was specific for testicular incretion and indicated the endocrine reserve of the testes. There is a discussion concerning the importance of the functional testing of the incretion capacity of testes for differential diagnosis different forms o incretion hypogonadism.

Animals↗
PubMed1978

[Variation of the serum testosterone level in boars during 24 hours and during a period of several days].

Seven sexually mature boars were studied in two-hour intervals for 8 to 32 hours, as to the variation of testosterone levels in the blood plasma. Blood samples were obtained by means of a cannula inserted in the v. cava cranialis. The hormone level under study showed marked fluctuation. The coefficient of variation of testosterone concentration ranged from 12.7% to 35.2% in the individual animals and for the whole part of the study it was 33.0%. It appeared impossible to derive seriously any regular periodicity of testosterone concentration in boar blood in the 24-hour period from the analysis of the variation of the levels of the hormone in individual animals during the period under study. Further, the study revealed a marked fluctuation of testosterone levels in the blood plasma of twelve sexually mature boars in the course of several days' study. The coefficient of variation of testosterone concentration in individual animals ranged from 18.1% to 106.5%, reaching 77.0% for the whole part of study. The analysis of variance showed statistically significant differences of hormonal levels in individual boars in which the fluctuation of testosterone was studied in the 8- to 32-hour period as well as in several days' period. This proved the role of the animals' individuality in determining the concentration of testosterone in their blood. The discussion concerns the importance of these findings for the evaluation of the role of basal testosterone levels in the blood in classifying the incretion function of the gonads and in the diagnosis of incretion hypogonadism of boars.

Age Factors↗
PubMed1978

[Effect of bilateral orchidectomy on serum testosterone levels in boars].

Bilateral orchidectomy caused a marked decrease in the concentration of testosterone in the bood plasma of boars already in the early post-castration stage of three hours after the operation. In the period from 3 to 207 days after castration, the pre-operation levels of plasma testosterone decrease by 84.4%, on an average. Adreno-cortical compensation of the concentration of the hormone did not occur in the post-castration period. The conclusion is that the levels of testosterone in the blood of boars are mostly of testicular origin and can be considered as the main criterion of the incretion function of the testes. The discussion concerns the practical importance of the determination of testosterone levels in the blood of boars for clinical evaluation of the hormonal function of the testes and for diagnostics of incretion hypogonodism.

Animals↗
PubMed1977

Ischemic bowel disease following bilateral nephrectomy or renal transplant.

In a 2 year period five patients developed pathologically proved ischemic bowel disease (IBD) following either renal transplantation or bilateral nephrectomy in preparations for transplantation. This entity accounted for 42% of all major gastrointestinal complications in this transplant unit. Three patients presented with abdominal pain and ileus, and two patients developed massive lower gastrointestinal hemorrhage. All five patients had nonocclusive ischemic disease because obstruction of a major intestinal vessel could not be documented in any case. Each patient was treated with bowel resection and three of the five patients survived. Although sepsis, shock, and large doses of immunosuppressive drugs have been implicated in predisposing such patients to IBD, these factors were not uniformly present in our cases. Blood volume redistribution with transient episodes of hypotension, especially during postoperative hemodialysis, may be significant. IBD in uremic patients can occur in the presence or absence of renal transplantation and may be the cause of massive intestinal hemorrhage in these individuals.

Adult↗